DRSC/TRiP Functional Genomics Resources

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Protein Alignment luna and KLF4

DIOPT Version :9

Sequence 1:NP_001260879.1 Gene:luna / 2768719 FlyBaseID:FBgn0040765 Length:570 Species:Drosophila melanogaster
Sequence 2:NP_001300981.1 Gene:KLF4 / 9314 HGNCID:6348 Length:513 Species:Homo sapiens


Alignment Length:651 Identity:165/651 - (25%)
Similarity:235/651 - (36%) Gaps:238/651 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 ILPSGNIFSELERICTTGYYSSQPSI------EDQWQQTCYELERYLRDEPKLQKKMHSNLDNPW 61
            :|||.:.|:       :|....:.::      .::|::   ||....|..|.|..:       |:
Human    16 LLPSFSTFA-------SGPAGREKTLRQAGAPNNRWRE---ELSHMKRLPPVLPGR-------PY 63

  Fly    62 DIFSTPARLLEELKIKEQHLDTIST---TSSVSSNCSGTSWDSNGSQALSCSVLVKQERIDEEDD 123
            |:.:.                |::|   :....:.|.|:          :.:.|.::| .:|.:|
Human    64 DLAAA----------------TVATDLESGGAGAACGGS----------NLAPLPRRE-TEEFND 101

  Fly   124 DVGCDDKLSVLLAAPPSAISPNPSIGSAGNMTPTSISNSSSISSSNSHSNSNGNTTGSSNIIASP 188
            .:..|..||..|..||.:::             .::|:|:|.|||:|.|:|..            
Human   102 LLDLDFILSNSLTHPPESVA-------------ATVSSSASASSSSSPSSSGP------------ 141

  Fly   189 LSSLGSGSTITVSSRNSSAPGIKVRVVQAKNHPGSNARMHLGHVQDFVLPTLTPPSSPESNLRSH 253
             :|..|..:.|...|..:.||:.         ||......|     :...:..||::|      .
Human   142 -ASAPSTCSFTYPIRAGNDPGVA---------PGGTGGGLL-----YGRESAPPPTAP------F 185

  Fly   254 NYAQQLEANDLAALIQQQQQQQQQQQQQQQQQQLNPQPGNSTPATAILRFTSQSNPTMTQLQQQQ 318
            |.|   :.||                       ::|..|.   ...:||      |.:..:....
Human   186 NLA---DIND-----------------------VSPSGGF---VAELLR------PELDPVYIPP 215

  Fly   319 QQLAVQHLSISPQALGHSNIGSNSPKSSSSSSSNSSNSSSSSHSSSSSISGSSD---QPTHSNIP 380
            ||         ||..|...:|....|:|.|:..:...|.|....|..|..||..   .|.:...|
Human   216 QQ---------PQPPGGGLMGKFVLKASLSAPGSEYGSPSVISVSKGSPDGSHPVVVAPYNGGPP 271

  Fly   381 R----------STIVRL----TTANG-KPGAAGISLARVIQMQNNGNANVAAVLSAAANSGSSNS 430
            |          |:...|    ..:|| :|.|....|.|.:..:......:..||           
Human   272 RTCPKIKQEAVSSCTHLGAGPPLSNGHRPAAHDFPLGRQLPSRTTPTLGLEEVL----------- 325

  Fly   431 NSNSSSSNTSSNSINTATP---------------------QQQV--------------------- 453
                     ||...:.|.|                     |.||                     
Human   326 ---------SSRDCHPALPLPPGFHPHPGPNYPSFLPDQMQPQVPPLHYQGQSRGFVARAGEPCV 381

  Fly   454 --------------LSQRSEKSANGSSKPHHPRQHHSDHS-PDAKRRIHKCQFLGCKKVYTKSSH 503
                          .|...|....||..|..|:......| |..:...|.|.:.||.|.||||||
Human   382 CWPHFGTHGMMLTPPSSPLELMPPGSCMPEEPKPKRGRRSWPRKRTATHTCDYAGCGKTYTKSSH 446

  Fly   504 LKAHQRTHTGEKPYKCSWEGCEWRFARSDELTRHYRKHTGAKPFKCRNCDRCFSRSDHLALHMKR 568
            ||||.|||||||||.|.|:||.|:||||||||||||||||.:||:|:.|||.|||||||||||||
Human   447 LKAHLRTHTGEKPYHCDWDGCGWKFARSDELTRHYRKHTGHRPFQCQKCDRAFSRSDHLALHMKR 511

  Fly   569 H 569
            |
Human   512 H 512

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
lunaNP_001260879.1 COG5048 <455..>559 CDD:227381 61/104 (59%)
C2H2 Zn finger 489..511 CDD:275368 15/21 (71%)
zf-H2C2_2 503..>519 CDD:290200 14/15 (93%)
C2H2 Zn finger 519..541 CDD:275368 17/21 (81%)
zf-H2C2_2 533..558 CDD:290200 18/24 (75%)
C2H2 Zn finger 549..569 CDD:275368 16/19 (84%)
KLF4NP_001300981.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 22..45 2/29 (7%)
9aaTAD. /evidence=ECO:0000269|PubMed:31375868 101..109 2/7 (29%)
Interaction with ZNF296. /evidence=ECO:0000250|UniProtKB:Q60793 416..513 67/97 (69%)
COG5048 <425..508 CDD:227381 59/82 (72%)
zf-C2H2 430..454 CDD:278523 16/23 (70%)
C2H2 Zn finger 432..454 CDD:275368 15/21 (71%)
C2H2 Zn finger 462..484 CDD:275368 17/21 (81%)
Interaction with target DNA. /evidence=ECO:0000250 473..504 24/30 (80%)
zf-H2C2_2 476..501 CDD:290200 18/24 (75%)
C2H2 Zn finger 492..512 CDD:275368 16/19 (84%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151423
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23235
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.940

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