DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment luna and RPN4

DIOPT Version :9

Sequence 1:	NP_001260879.1	Gene:	luna / 2768719	FlyBaseID:	FBgn0040765	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_010264.3	Gene:	RPN4 / 851542	SGDID:	S000002178	Length:	531	Species:	Saccharomyces cerevisiae

Alignment Length:	506	Identity:	107/506 - (21%)
Similarity:	172/506 - (33%)	Gaps:	145/506 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 PNPSIGSAGNMTPTSISNSSSISSSN--SHSNSNGNTTGSSNI-------------IASPLSSLG 193
            ||.||      ||..:.|.:..:::.  :||..:.|.:.:::|             .|.|..:..
Yeast    39 PNASI------TPYKLVNKNKENNTFTWNHSLQHQNESSAASIPPQQTYHFPIFNKYADPTLTTT 97

  Fly   194 SGSTITVSSRN-----------------SSAPGIKVRVVQAKNHPGSNARMHLGHVQDFVLPTLT 241
            :..|.:.::.|                 |..|  ..:.|..||         :..|.|..:||
Yeast    98 TSFTTSEATANDRQINNVHLIPNEIKGASETP--LQKTVNLKN---------IMKVSDPYVPT-- 149

  Fly   242 PPSSPESNLRSHNY-----------AQQLEANDLAALIQQQQQQQQQQQQQQQQQQLNPQPGNST 295
                    ..:.||           ...|..||...|..:.....:.|...|.    |....|:.
Yeast   150 --------RNTFNYDVKISNDFFDNGDNLYGNDEEVLFYEDNYNPKMQWSLQD----NSAAINNE 202

  Fly   296 PATAIL--RFTSQSNPTMTQ---------LQQQQ-QQLAVQHLSISPQALGHSNIGSNSPKSSSS 348
            .|.||.  .|.|..:.....         |||:| |:..:..|.::|.::    .||:.....:.
Yeast   203 DARAIFNNEFDSDDDDISDDEEDEIEENCLQQEQHQEEPLLSLDVTPISM----FGSDQKTGRAK 263

  Fly   349 SSSNSSNSSSSSHSSSSSISG--------------SSDQPTHSNIPRSTIVRLTTANGKPGAAGI 399
            |||:..|..|...|:..|||.              ..|:...:::....|..::....:...:.:
Yeast   264 SSSHLFNEYSYVDSNMDSISSVVSEDLLDERGHEKIEDEDEDNDLDEDDIYDISLLKNRRKQSFV 328

  Fly   400 SLARVIQMQNNGNANVAAVLSAAANSGSSNSNSNSSSSNTSSNSINTAT------PQQQVLSQR- 457
            .....|..:...:.:.:|.:.:.|.:|......:||:.:..|||....|      |...|:|..
Yeast   329 LNKNTIDFERFPSPSTSANVPSTATTGKRKPAKSSSNRSCVSNSNENGTLERIKKPTSAVVSSNA 393

  Fly   458 --------------SEKSANGSSKPH--HPRQHHSDHSPDAKRRIHKCQFLG------CKKVYTK 500
                          |..|.|.:|||.  .|..|.|  |.|....|..||.:.      |...:::
Yeast   394 SRRKLINYTKKHLSSHSSTNSNSKPSTASPSAHTS--SSDGNNEIFTCQIMNLITNEPCGAQFSR 456

  Fly   501 SSHLKAHQRT-HTGEK-PYKCS-------WEGCEWRFARSDELTRHYR-KH 541
            |..|..||.| |...| .::||       .||.:..|:|.|.||||.: ||
Yeast   457 SYDLTRHQNTIHAKRKIVFRCSECIKILGSEGYQKTFSRLDALTRHIKSKH 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
luna	NP_001260879.1	COG5048	<455..>559	CDD:227381	36/120 (30%)
		C2H2 Zn finger	489..511	CDD:275368	8/28 (29%)
		zf-H2C2_2	503..>519	CDD:290200	6/17 (35%)
		C2H2 Zn finger	519..541	CDD:275368	11/29 (38%)
		zf-H2C2_2	533..558	CDD:290200	6/10 (60%)
		C2H2 Zn finger	549..569	CDD:275368
RPN4	NP_010264.3	C2H2 Zn finger	450..468	CDD:275368	6/17 (35%)
RPN4	NP_010264.3	C2H2 Zn finger	477..504	CDD:275368	11/26 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	51	1.000	Inparanoid score	I1833
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050