DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment luna and Klf10

DIOPT Version :9

Sequence 1:	NP_001260879.1	Gene:	luna / 2768719	FlyBaseID:	FBgn0040765	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_112397.1	Gene:	Klf10 / 81813	RGDID:	621652	Length:	480	Species:	Rattus norvegicus

Alignment Length:	365	Identity:	117/365 - (32%)
Similarity:	161/365 - (44%)	Gaps:	54/365 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   240 LTPPSSPESNLRSHNYA---------QQLEANDLAALIQQQQQQQQQQQQQQQQQQLNPQPGNST 295
            ||.|:.|..:.||.:.|         ::.|.:.|||....:.|.....:.....|..|.|   |.
  Rat   108 LTAPAPPTGHFRSLSDAAKPPSIAPFKEEEKSPLAAPPLPKAQATSVIRHTADAQLCNHQ---SC 169

  Fly   296 P--ATAILRFTSQSNPTMTQLQQQQQQLAVQHLSISPQALGHSNIGSNSPKSSSSSSSNSSNSSS 358
            |  |.:||.:...|....|.:..:..:..:...::||          |.||...|:::|.:..:.
  Rat   170 PVKAASILNYQDNSFRRRTHINVEATRKNIPCAAVSP----------NRPKPEPSTAANGAEKAG 224

  Fly   359 SS------HSSSSSISGSSDQPTHSNIPRSTIVRLTTANGKPGAAGISLARVIQMQNNGNANVAA 417
            ::      .||.:.|..||.....|.:.:|.::...|.:    ..|:....||.......||.:.
  Rat   225 TAPYDFAVPSSETVICRSSQPAPTSPVQKSVLMSSPTVS----TGGVPPLPVICQMVPLPANNSL 285

  Fly   418 VLSAAANSGSSNSNSNSS-----SSNTSSNSINTATPQQQVLSQRSE-KSANGSS-KPHHPRQHH 475
            |.:...:|..|...:..|     .:.....::....||..|.|.:.. .|.||:. .|..|.
  Rat   286 VTTVVPSSPPSQPPAVCSPVLFMGTQVPKGTVMFVVPQPVVQSPKPPVVSPNGTRLSPIAPA--- 347

  Fly   476 SDHSPDAKR----------RIHKCQFLGCKKVYTKSSHLKAHQRTHTGEKPYKCSWEGCEWRFAR 530
            ...||.|.|          |.|.|...||.|.|.||||||||.||||||||:.|||:|||.||||
  Rat   348 PGFSPSAARVTPQIDSSRVRSHICSHPGCGKTYFKSSHLKAHVRTHTGEKPFSCSWKGCERRFAR 412

  Fly   531 SDELTRHYRKHTGAKPFKCRNCDRCFSRSDHLALHMKRHM 570
            ||||:||.|.|||.|.|.|..|||.|.|||||..|.:||:
  Rat   413 SDELSRHRRTHTGEKKFACPMCDRRFMRSDHLTKHARRHL 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
luna	NP_001260879.1	COG5048	<455..>559	CDD:227381	60/115 (52%)
		C2H2 Zn finger	489..511	CDD:275368	14/21 (67%)
		zf-H2C2_2	503..>519	CDD:290200	13/15 (87%)
		C2H2 Zn finger	519..541	CDD:275368	17/21 (81%)
		zf-H2C2_2	533..558	CDD:290200	15/24 (63%)
		C2H2 Zn finger	549..569	CDD:275368	11/19 (58%)
Klf10	NP_112397.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32
		KLF10_N	33..369	CDD:409241	60/280 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	64..83
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	97..146		11/37 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	202..222		7/29 (24%)
		zf-C2H2	369..393	CDD:395048	15/23 (65%)
		C2H2 Zn finger	374..393	CDD:275368	13/18 (72%)
		zf-H2C2_2	385..412	CDD:404364	21/26 (81%)
		C2H2 Zn finger	401..423	CDD:275368	17/21 (81%)
		zf-C2H2	429..451	CDD:395048	12/21 (57%)
		C2H2 Zn finger	431..451	CDD:275368	11/19 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010