DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment luna and klf12a

DIOPT Version :9

Sequence 1:	NP_001260879.1	Gene:	luna / 2768719	FlyBaseID:	FBgn0040765	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	XP_021331523.1	Gene:	klf12a / 798629	ZFINID:	ZDB-GENE-030131-9188	Length:	380	Species:	Danio rerio

Alignment Length:	401	Identity:	140/401 - (34%)
Similarity:	182/401 - (45%)	Gaps:	109/401 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 LPTLTPPSSP-ESNLRS---HNYAQQLEANDLAALIQQQQQQQQQQQQQQQQQQLNPQPGNSTPA 297
            :|||....:| ||..||   |:|      .::..|:..::.:.|...:
Zfish    14 MPTLPVKINPAESQRRSPVIHDY------TEMGVLVLNRRFRTQPDDR----------------- 55

  Fly   298 TAILRFTSQSNPTMTQLQQQQQQLAVQHLSISPQALGHSNIGSNSPKSSSSS------SSNSSNS 356
                ||.  |:|..|  |.:...|:......||.....|:: |:||.|||||      |..||.|
Zfish    56 ----RFL--SDPFQT--QTEPVDLSTNKARTSPSLSASSSL-SSSPSSSSSSIRFCPRSPPSSKS 111

  Fly   357 SSSSHSSSSSISGSSDQPTHSNIPR-----STIVRLTTANGKPGAAGISLARVIQMQNNGNANV- 415
            ..||..||.|:..||.....:.:||     |..|.:.::....|..|.|...:.|:....::.|
Zfish   112 LPSSSPSSLSMPSSSSTSVITPVPRLKMSPSCSVPVVSSLPSRGLRGQSFLHIPQLMPPCSSPVH 176

  Fly   416 -------------AAVLSAAANSGSS---------------------------NSNSNS------ 434
                         ..|.....:.|||                           .|.|:|
Zfish   177 IHPRRVPVVVQPMPLVYPGVGSLGSSRLMMPLLEENRMHRKVMHRMADGLSPRRSLSDSEDDDLP 241

  Fly   435 -----SSSNTSSNSINTATPQQQVLSQRSEKSANGSSKPHHPRQHHSDHSPDAK-RRIHKCQFLG 493
                 |.:.|.|.::..|...|..|...|.:|.         |:.....|||:| ||||:|:|.|
Zfish   242 NVTLESVNETGSTALTIARAVQDSLLPFSIESL---------RRPRPSESPDSKRRRIHRCEFEG 297

  Fly   494 CKKVYTKSSHLKAHQRTHTGEKPYKCSWEGCEWRFARSDELTRHYRKHTGAKPFKCRNCDRCFSR 558
            |.||||||||||||:|||||||||||:|:.|.|:||||||||||||||||.|||||.:|||.|||
Zfish   298 CNKVYTKSSHLKAHRRTHTGEKPYKCTWDNCTWKFARSDELTRHYRKHTGVKPFKCSDCDRSFSR 362

  Fly   559 SDHLALHMKRH 569
            |||||||.:||
Zfish   363 SDHLALHRRRH 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
luna	NP_001260879.1	COG5048	<455..>559	CDD:227381	67/104 (64%)
		C2H2 Zn finger	489..511	CDD:275368	17/21 (81%)
		zf-H2C2_2	503..>519	CDD:290200	14/15 (93%)
		C2H2 Zn finger	519..541	CDD:275368	16/21 (76%)
		zf-H2C2_2	533..558	CDD:290200	20/24 (83%)
		C2H2 Zn finger	549..569	CDD:275368	14/19 (74%)
klf12a	XP_021331523.1	SFP1	<217..370	CDD:227516	83/161 (52%)
		C2H2 Zn finger	296..315	CDD:275368	15/18 (83%)
		C2H2 Zn finger	323..345	CDD:275368	16/21 (76%)
		zf-H2C2_2	337..362	CDD:316026	20/24 (83%)
		C2H2 Zn finger	353..373	CDD:275368	14/19 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585890
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000436
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.940