DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment luna and KLF10

DIOPT Version :9

Sequence 1:	NP_001260879.1	Gene:	luna / 2768719	FlyBaseID:	FBgn0040765	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_005646.1	Gene:	KLF10 / 7071	HGNCID:	11810	Length:	480	Species:	Homo sapiens

Alignment Length:	561	Identity:	144/561 - (25%)
Similarity:	214/561 - (38%)	Gaps:	140/561 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 QQTCYELERYLRDEPKLQKKMHSNLDNPWDIFSTPARLLEELKIKEQHLDTISTTSSVSSNCSGT 97
            |||..|....:.:.||  :.|:|     |:            |..|:. |..:..:.:|.:|
Human     9 QQTAEERMEMISERPK--ESMYS-----WN------------KTAEKS-DFEAVEALMSMSC--- 50

  Fly    98 SWDSNGSQALSCSVLVKQERIDEEDDDV-GCDDKLSVLLAAPPSAISP--NPSIGSAGNMTPTSI 159
            ||.|:..:.:....:.....:.||::.: |..|..::    |...::|  :||     :..|:.:
Human    51 SWKSDFKKYVENRPVTPVSDLSEEENLLPGTPDFHTI----PAFCLTPPYSPS-----DFEPSQV 106

  Fly   160 SNSSSISSSNSHSNSNGNTTGSSNIIASPLSSLGSGSTITVSSRNSSAPGIKVRVVQAKNHPGSN 224
            ||..:.:.|..|..|..:|  :...||:|.            .....:|      |.|...|.:.
Human   107 SNLMAPAPSTVHFKSLSDT--AKPHIAAPF------------KEEEKSP------VSAPKLPKAQ 151

  Fly   225 ARMHLGHVQDFVLPTLTPPSSPESNLRSHNYAQQLEANDLAALIQQQQQQQQQQQQQQQQQQLNP 289
            |...:.|..|             :.|.:|                                |..|
Human   152 ATSVIRHTAD-------------AQLCNH--------------------------------QTCP 171

  Fly   290 QPGNSTPATAILRFTSQSNPTMTQLQQQQQQLAVQHLSISPQALGHSNIGSNSPKSSSSSSSNSS 354
            .     .|.:||.:.:.|....|.|..:..:..:...::||          |..|...::.::..
Human   172 M-----KAASILNYQNNSFRRRTHLNVEAARKNIPCAAVSP----------NRSKCERNTVADVD 221

  Fly   355 NSSS------SSHSSSSSISGSSDQPTHSNIPRSTIVRLTTANGKPGAAGISLARVIQMQNNGNA 413
            ..:|      |..||.:.|..|...|. |...:|.:|.....:    |.|:....||.......|
Human   222 EKASAALYDFSVPSSETVICRSQPAPV-SPQQKSVLVSPPAVS----AGGVPPMPVICQMVPLPA 281

  Fly   414 NVAAVLSAAANSGSSNSNSNS-----SSSNTSSNSINTATPQQQVLSQRSE-KSANGSS-KPHHP 471
            |...|.:...::..|...:..     ..:.....::....||..|.|.:.. .|.||:. .|..|
Human   282 NNPVVTTVVPSTPPSQPPAVCPPVVFMGTQVPKGAVMFVVPQPVVQSSKPPVVSPNGTRLSPIAP 346

  Fly   472 RQHHSDHSP------DAKR-RIHKCQFLGCKKVYTKSSHLKAHQRTHTGEKPYKCSWEGCEWRFA 529
            ....|..:.      |:.| |.|.|...||.|.|.||||||||.||||||||:.|||:|||.|||
Human   347 APGFSPSAAKVTPQIDSSRIRSHICSHPGCGKTYFKSSHLKAHTRTHTGEKPFSCSWKGCERRFA 411

  Fly   530 RSDELTRHYRKHTGAKPFKCRNCDRCFSRSDHLALHMKRHM 570
            |||||:||.|.|||.|.|.|..|||.|.|||||..|.:||:
Human   412 RSDELSRHRRTHTGEKKFACPMCDRRFMRSDHLTKHARRHL 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
luna	NP_001260879.1	COG5048	<455..>559	CDD:227381	59/112 (53%)
		C2H2 Zn finger	489..511	CDD:275368	14/21 (67%)
		zf-H2C2_2	503..>519	CDD:290200	13/15 (87%)
		C2H2 Zn finger	519..541	CDD:275368	17/21 (81%)
		zf-H2C2_2	533..558	CDD:290200	15/24 (63%)
		C2H2 Zn finger	549..569	CDD:275368	11/19 (58%)
KLF10	NP_005646.1	zf-C2H2	369..393	CDD:278523	15/23 (65%)
		COG5048	374..>424	CDD:227381	37/49 (76%)
		C2H2 Zn finger	374..393	CDD:275368	13/18 (72%)
		zf-H2C2_2	385..412	CDD:290200	21/26 (81%)
		C2H2 Zn finger	401..423	CDD:275368	17/21 (81%)
		zf-H2C2_2	415..438	CDD:290200	14/22 (64%)
		zf-C2H2	429..451	CDD:278523	12/21 (57%)
		C2H2 Zn finger	431..451	CDD:275368	11/19 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010