DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment luna and KLF5

DIOPT Version :9

Sequence 1:	NP_001260879.1	Gene:	luna / 2768719	FlyBaseID:	FBgn0040765	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_001721.2	Gene:	KLF5 / 688	HGNCID:	6349	Length:	457	Species:	Homo sapiens

Alignment Length:	307	Identity:	118/307 - (38%)
Similarity:	161/307 - (52%)	Gaps:	43/307 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   283 QQQQLNPQPGNSTPATAILRFTSQSNPTMTQLQQQ-----QQQLAVQ--HLSISPQALGHSNIGS 340
            |.:...|.|   .|..|:..|||..:...|...:.     :|:|...  |||: |...||.....
Human   172 QSETTAPPP---APTQALPEFTSIFSSHQTAAPEVNNIFIKQELPTPDLHLSV-PTQQGHLYQLL 232

  Fly   341 NSPKSSSSSSSNSSNSSSSSH-SSSSSISGSSDQPTH-SNIPRSTIVRLTTANGKPGAAGISLAR 403
            |:|.....||:|.:.:..:.: |.|::::|.:   || |.:|::.:.:.   .|.|.......::
Human   233 NTPDLDMPSSTNQTAAMDTLNVSMSAAMAGLN---THTSAVPQTAVKQF---QGMPPCTYTMPSQ 291

  Fly   404 VIQMQNNGNANVAAVLSAAANSGSSNSNSNSSSSNTSSNSINTATPQQQVLSQRSEKSA------ 462
            .:..|             |.....|..:|...|.:..:..:...||.....:..:.|.|
Human   292 FLPQQ-------------ATYFPPSPPSSEPGSPDRQAEMLQNLTPPPSYAATIASKLAIHNPNL 343

  Fly   463 ----NGSSKPHHPRQHHSDHSPD-AKRRIHKCQFLGCKKVYTKSSHLKAHQRTHTGEKPYKCSWE 522
                ..:|:...|.:::...:|| .|||||.|.:.||.||||||||||||.|||||||||||:||
Human   344 PTTLPVNSQNIQPVRYNRRSNPDLEKRRIHYCDYPGCTKVYTKSSHLKAHLRTHTGEKPYKCTWE 408

  Fly   523 GCEWRFARSDELTRHYRKHTGAKPFKCRNCDRCFSRSDHLALHMKRH 569
            ||:||||||||||||||||||||||:|..|:|.||||||||||||||
Human   409 GCDWRFARSDELTRHYRKHTGAKPFQCGVCNRSFSRSDHLALHMKRH 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
luna	NP_001260879.1	COG5048	<455..>559	CDD:227381	68/114 (60%)
		C2H2 Zn finger	489..511	CDD:275368	16/21 (76%)
		zf-H2C2_2	503..>519	CDD:290200	14/15 (93%)
		C2H2 Zn finger	519..541	CDD:275368	19/21 (90%)
		zf-H2C2_2	533..558	CDD:290200	19/24 (79%)
		C2H2 Zn finger	549..569	CDD:275368	15/19 (79%)
KLF5	NP_001721.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..83
		9aaTAD. /evidence=ECO:0000269\|PubMed:31375868	118..126
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	295..321		5/38 (13%)
		Interaction with WWP1. /evidence=ECO:0000269\|PubMed:15735697	324..328		1/3 (33%)
		COG5048	359..>433	CDD:227381	57/73 (78%)
		C2H2 Zn finger	378..397	CDD:275368	15/18 (83%)
		C2H2 Zn finger	405..427	CDD:275368	19/21 (90%)
		zf-C2H2	433..455	CDD:306579	16/21 (76%)
		C2H2 Zn finger	435..455	CDD:275368	15/19 (79%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151404
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	176	1.000	Inparanoid score	I4047
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.950