Protein Alignment luna and SP4

DIOPT Version :10

• Sequence 1: NP_995811.1
• Gene: luna / 2768719
• FlyBaseID: FBgn0040765
• Length: 570
• Species: Drosophila melanogaster
• Sequence 2: NP_003103.2
• Gene: SP4 / 6671
• HGNCID: 11209
• Length: 784
• Species: Homo sapiens
• Alignment Length: 749
• Identity: 172/749 - (22%)
• Similarity: 275/749 - (36%)
• Gaps: 253/749 - (33%)

  Fly    18 TTGYYSSQPSIEDQWQQTCYELER---------------------YLRDEPKLQKKMHSNL-DNP 60
            |:|...||||.......||.::..                     .|:::|:..:.:.:.| .|.
Human    37 TSGSQDSQPSPLALLAATCSKIGTPGENQATGQQQIIIDPSQGLVQLQNQPQQLELVTTQLAGNA 101

  Fly    61 WDIFSTPARLLEELKIKEQHLDTISTTSSVSSNCSGTSWDSNGS---------QALSCSVLVKQE 116
            |.:.::.....:|..:.:....:.|::||.:.:.|.|...|..|         |..:.|..|:.:
Human   102 WQLVASTPPASKENNVSQPASSSSSSSSSNNGSASPTKTKSGNSSTPGQFQVIQVQNPSGSVQYQ 166

  Fly   117 RIDEEDDDVGCDDKLSVLLAAPPSAISPNPSIGSA-----GNMTPTSISNSSSISSSNSHSNSNG 176
            .|.:             |.......|..||:..|:     |.:...|..|:.:|.::       .
Human   167 VIPQ-------------LQTVEGQQIQINPTSSSSLQDLQGQIQLISAGNNQAILTA-------A 211

  Fly   177 NTTGSSNIIASPLSSLGSGSTITVSSRNSSAPGIKVRVVQAKNHPGSNAR------MHLGHVQDF 235
            |.|.|.||:|..|::    .|:.|..|    ||:.: .:|.:..||:.|:      :::|.| ..
Human   212 NRTASGNILAQNLAN----QTVPVQIR----PGVSI-PLQLQTLPGTQAQVVTTLPINIGGV-TL 266

  Fly   236 VLPTL-----------------------------------------TPPSSPES----------N 249
            .||.:                                         |.|.||.|          :
Human   267 ALPVINNVAAGGGTGQVGQPAATADSGTSNGNQLVSTPTNTTTSASTMPESPSSSTTCTTTASTS 331

  Fly   250 LRSHN----------YA---------------------------QQLEAN------DLAALIQQ- 270
            |.|.:          ||                           .||:.|      |.:..:||
Human   332 LTSSDTLVSSADTGQYASTSASSSERTIEESQTPAATESEAQSSSQLQPNGMQNAQDQSNSLQQV 396

  Fly   271 -------QQQQQQQQQQQQQQQQLNPQPGNSTPATAILRFTSQSNPTMTQLQQQQQQLAVQHLSI 328
                   .||.|.||.|||..|.:.||           .|..||..|:..:|||..| .||..::
Human   397 QIVGQPILQQIQIQQPQQQIIQAIPPQ-----------SFQLQSGQTIQTIQQQPLQ-NVQLQAV 449

  Fly   329 SP------------------QALGHSNIGS-------NSPKSSSSSSSNSSNSSSSSHSSSSSIS 368
            :|                  |.:...||.|       |:..|...:.:..|:|..::.:..:.::
Human   450 NPTQVLIRAPTLTPSGQISWQTVQVQNIQSLSNLQVQNAGLSQQLTITPVSSSGGTTLAQIAPVA 514

  Fly   369 GSSDQPTHSNIPRSTIVRLTTAN-GKPGAAGISLARV------IQMQNNG-------NANVAAVL 419
            .:....|.:....:::..|.|.: ...||||:.:..|      :..|..|       .|.:|.|
Human   515 VAGAPITLNTAQLASVPNLQTVSVANLGAAGVQVQGVPVTITSVAGQQQGQDGVKVQQATIAPV- 578

  Fly   420 SAAANSGSSNSNSNSSSSNTSSNSINTATPQQ--QVLSQRSEKSANGSSKPHHPRQHHSDHSPD- 481
             ..|..|.:|:            :|...:|.|  ||..|:.:::::...:|....:..:...|:
Human   579 -TVAVGGIANA------------TIGAVSPDQLTQVHLQQGQQTSDQEVQPGKRLRRVACSCPNC 630

  Fly   482 -----------AKRRIHKCQFLGCKKVYTKSSHLKAHQRTHTGEKPYKCSWEGCEWRFARSDELT 535
                       .|::.|.|...||.|||.|:|||:||.|.||||:|:.|:|..|..||.|||||.
Human   631 REGEGRGSNEPGKKKQHICHIEGCGKVYGKTSHLRAHLRWHTGERPFICNWMFCGKRFTRSDELQ 695

  Fly   536 RHYRKHTGAKPFKCRNCDRCFSRSDHLALHMKRH 569
            ||.|.|||.|.|:|..|.:.|.|||||:.|:|.|
Human   696 RHRRTHTGEKRFECPECSKRFMRSDHLSKHVKTH 729

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
luna	NP_995811.1	KLF6_7_N-like	2..>82	CDD:409246	14/85 (16%)
		COG5048	<455..>559	CDD:227381	44/115 (38%)
		C2H2 Zn finger	489..511	CDD:275368	13/21 (62%)
		C2H2 Zn finger	519..541	CDD:275368	13/21 (62%)
		zf-H2C2_2	533..558	CDD:463886	13/24 (54%)
		C2H2 Zn finger	549..569	CDD:275368	10/19 (53%)
SP4	NP_003103.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..68		8/30 (27%)
		SP4_N	32..648	CDD:411773	124/666 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	109..150		8/40 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	281..390		13/108 (12%)
		9aaTAD, inactive. /evidence=ECO:0000269|PubMed:31375868	467..475		1/7 (14%)
		zf-C2H2	647..671	CDD:395048	14/23 (61%)
		C2H2 Zn finger	649..671	CDD:275368	13/21 (62%)
		zf-C2H2	677..701	CDD:395048	13/23 (57%)
		C2H2 Zn finger	679..701	CDD:275368	13/21 (62%)
		zf-H2C2_2	693..716	CDD:463886	12/22 (55%)
		zf-C2H2	707..729	CDD:395048	11/21 (52%)
		C2H2 Zn finger	709..729	CDD:275368	10/19 (53%)