DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment luna and klf17

DIOPT Version :9

Sequence 1:	NP_001260879.1	Gene:	luna / 2768719	FlyBaseID:	FBgn0040765	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_571798.1	Gene:	klf17 / 65238	ZFINID:	ZDB-GENE-010129-1	Length:	409	Species:	Danio rerio

Alignment Length:	492	Identity:	147/492 - (29%)
Similarity:	195/492 - (39%)	Gaps:	141/492 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 IDEEDDDVGCDDKLSVLLAAPPSAISPNPSIGSAGNMTPT-----SISNSSSISS---------- 167
            :||:..::..|.|:.:....|           .||::.|.     ||..|..::.
Zfish    20 LDEKQSEIVRDWKVDIAKTNP-----------RAGDVRPLIEVEFSIVESPPLAKDEDDLSKFLD 73

  Fly   168 -----SNSHSNSNGNTTGSSNIIASPLSSLGSGSTITVSSRNSSAPGIKVRVVQAKNHPGSNARM 227
                 ||:.::.|.||:......:.| .|..|.||:..|......|..         :.|:|...
Zfish    74 LEFILSNTVTSDNDNTSAPPPAYSLP-ESPESCSTVYDSDGCHPTPNA---------YCGTNFNS 128

  Fly   228 HLGHVQDFVLPTLTPPSS--PESNLRSHNYAQQLEANDLAALIQQQQQQQQQQQQQQQQQQLNPQ 290
            ..||  ..|....||..:  .|.||:.|  ..:||..:|.||            ..:.||.|.
Zfish   129 RPGH--SLVAELFTPDMNYQGEYNLKGH--LDRLEYTELRAL------------NTRNQQHLT-- 175

  Fly   291 PGNSTPATAILRFTSQS------NPTMTQLQQQQQQLAVQHLSISPQALGHSNIGSNSPKSSSSS 349
              ||..|...::..:|.      |..|.....|:.|..:||     |..||.
Zfish   176 --NSNNAGYKIKTENQEQSCMMVNDYMGHYYAQEPQRVMQH-----QTYGHH------------- 220

  Fly   350 SSNSSNSSSSSHSSSSSISGSSDQPTHSNIPRSTIVR----LTTANGKPGAAGISLARVIQMQNN 410
                                     ...::||..:.|    ||..|.:   ..|.::...|..||
Zfish   221 -------------------------VQQDVPRDILGRKDCILTEMNTQ---HHIDISHQQQFINN 257

  Fly   411 GNANVAAVLSAAANSGSSNSNSNSSSSNTSSN-----SINTATPQQQVLSQRSEKSANGSSKPHH 470
                 |......|.....:.:.|..|....:|     .:....|...:|...|.:    .|||..
Zfish   258 -----AHFPPQYAQHQQYHGHFNMFSEPLRANHPAMPGVMLTPPSSPLLGFLSPE----DSKPKR 313

  Fly   471 PRQHHSDHSPDAKRR--IHKCQFLGCKKVYTKSSHLKAHQRTHTGEKPYKCSWEGCEWRFARSDE 533
            .|:..      |::|  .|.|:|.||.|.||||||||||.|||||||||.||||||.|:||||||
Zfish   314 GRRSW------ARKRTATHSCEFPGCGKTYTKSSHLKAHMRTHTGEKPYHCSWEGCGWKFARSDE 372

  Fly   534 LTRHYRKHTGAKPFKCRNCDRCFSRSDHLALHMKRHM 570
            ||||||||||.:||:|..|:|.|||||||||||||||
Zfish   373 LTRHYRKHTGHRPFQCHLCERAFSRSDHLALHMKRHM 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
luna	NP_001260879.1	COG5048	<455..>559	CDD:227381	62/105 (59%)
		C2H2 Zn finger	489..511	CDD:275368	16/21 (76%)
		zf-H2C2_2	503..>519	CDD:290200	14/15 (93%)
		C2H2 Zn finger	519..541	CDD:275368	19/21 (90%)
		zf-H2C2_2	533..558	CDD:290200	17/24 (71%)
		C2H2 Zn finger	549..569	CDD:275368	15/19 (79%)
klf17	NP_571798.1	COG5048	<248..>393	CDD:227381	69/159 (43%)
		zf-C2H2	326..350	CDD:278523	17/23 (74%)
		C2H2 Zn finger	331..350	CDD:275368	14/18 (78%)
		zf-H2C2_2	342..>358	CDD:290200	14/15 (93%)
		C2H2 Zn finger	358..380	CDD:275368	19/21 (90%)
		zf-H2C2_2	372..397	CDD:290200	17/24 (71%)
		C2H2 Zn finger	388..408	CDD:275368	15/19 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010