DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment luna and klf8

DIOPT Version :9

Sequence 1:	NP_001260879.1	Gene:	luna / 2768719	FlyBaseID:	FBgn0040765	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_001073472.1	Gene:	klf8 / 562805	ZFINID:	ZDB-GENE-070424-152	Length:	343	Species:	Danio rerio

Alignment Length:	304	Identity:	112/304 - (36%)
Similarity:	154/304 - (50%)	Gaps:	50/304 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   293 NSTPATAILRF----TSQSNPTMTQLQQQQQQLAVQHLSISPQALGHSNIGSNSPKSSSSSSSNS 353
            :|.|...|:..    ..|:.|....|.:.:..|.:...:.:|..|...||       ::|::..:
Zfish    62 SSPPPLCIISTQHSDADQTEPVDLSLNKPRPSLPIATATSTPANLPPQNI-------TASATIPA 119

  Fly   354 SNSSSSSHSSSSSISG-----------SSDQPTH----SNIP---RSTIVRLTT--ANGKPGAAG 398
            ..|..|..:|:..:.|           |.:.|:.    ..||   :|..|..||  .:|...||
Zfish   120 VLSQGSILASTQGVGGQQILHVIHTIPSVNMPSKLGQLQTIPVVVQSLPVVYTTVPTDGMATAA- 183

  Fly   399 ISLARVIQMQNNGNANVAAVLSAAANSGSSNSNSNSSSSNTSSNSINTATPQQQVLSQRSEKSAN 463
               ..|..:.::|.:..:..:...:.|.....:.:.:.|.|.|.|.:.:|       |..|.|.|
Zfish   184 ---ITVPLIGSDGRSEGSVRIKPGSTSPVEYQSESDAESGTESGSASFST-------QGMEPSIN 238

  Fly   464 GS-SKPHHPRQHHSDHSPDAK-RRIHKCQFLGCKKVYTKSSHLKAHQRTHTGEKPYKCSWEGCEW 526
            .. ..|..|      .|||.| ||:|.|.:.||.||||||||||||:|.|||||||:|:||||.|
Zfish   239 TDVDIPADP------DSPDMKRRRVHMCDYDGCNKVYTKSSHLKAHRRIHTGEKPYQCTWEGCTW 297

  Fly   527 RFARSDELTRHYRKHTGAKPFKCRNCDRCFSRSDHLALHMKRHM 570
            |||||||||||:|||||.|||:|.:|||.||||||||||.:||:
Zfish   298 RFARSDELTRHFRKHTGIKPFRCTDCDRSFSRSDHLALHRRRHV 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
luna	NP_001260879.1	COG5048	<455..>559	CDD:227381	67/105 (64%)
		C2H2 Zn finger	489..511	CDD:275368	16/21 (76%)
		zf-H2C2_2	503..>519	CDD:290200	13/15 (87%)
		C2H2 Zn finger	519..541	CDD:275368	18/21 (86%)
		zf-H2C2_2	533..558	CDD:290200	18/24 (75%)
		C2H2 Zn finger	549..569	CDD:275368	14/19 (74%)
klf8	NP_001073472.1	repressor motif	82..86		1/3 (33%)
		zf-C2H2	258..282	CDD:278523	17/23 (74%)
		C2H2 Zn finger	260..282	CDD:275368	16/21 (76%)
		COG5048	<265..>330	CDD:227381	52/64 (81%)
		zf-H2C2_2	274..>291	CDD:290200	13/16 (81%)
		C2H2 Zn finger	290..312	CDD:275368	18/21 (86%)
		zf-H2C2_2	304..329	CDD:290200	18/24 (75%)
		C2H2 Zn finger	320..340	CDD:275368	14/19 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585896
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.940