DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment luna and klf4

DIOPT Version :9

Sequence 1:	NP_001260879.1	Gene:	luna / 2768719	FlyBaseID:	FBgn0040765	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_001106955.1	Gene:	klf4 / 562155	ZFINID:	ZDB-GENE-111014-1	Length:	396	Species:	Danio rerio

Alignment Length:	434	Identity:	127/434 - (29%)
Similarity:	178/434 - (41%)	Gaps:	108/434 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 SGSTITVSSRNSSAPGIKVRVVQAKNHPGSNARMHLGHVQ-----------DFVLPTLTPPSSPE 247
            ||:.:...|..:|...:|.:.|......||..:..:.|::           |..:|.:.....||
Zfish    14 SGTILPSISTFASGTDVKHKAVLGPGAAGSRWKEEMSHLKRPCMSTGATCADQDVPPVMAKIEPE 78

  Fly   248 SNLRSHNYAQQLEANDLAALIQQQQQQQQQQQQQQQQQQLNPQPGNSTPATAILRFT-SQSNPTM 311
                      :||..|...::.....|||||||....:.:        ||::...:| ...:|
Zfish    79 ----------ELELLDYDFILSNSLLQQQQQQQASTSRTI--------PASSPTHYTFPMPSP-- 123

  Fly   312 TQLQQQQQQLAVQHLS----------------ISPQALGHSNI-GSNSPKSSSSSSSNSSNSSSS 359
             |.|:......:..:|                :.|..|..::: |....|::...|..:...|.|
Zfish   124 -QGQEGSMLYTIPDISDVSPSGGFVAELMRPELDPAYLQPTSLHGKFVVKTTMDMSDYNQGVSIS 187

  Fly   360 SHSSS-------------SSISGSSDQPTHSNIPRSTIVRLTTANGKPGAAGISLARVIQMQNNG 411
            ..:|:             |:.:.|.....|             ..|....:|:....::...
Zfish   188 KDASAVPFACPRIKQECPSTCTASRPMDLH-------------LRGSSAQSGVHQGSMLDPH--- 236

  Fly   412 NANVAAVLSAAANSGSSNSNSNSSSSNTSSNSI------NTA------TPQQQVLSQRSEKSANG 464
                      |.:||....:|.|...:..:..:      |||      .|.|.:..|.....|.|
Zfish   237 ----------AFSSGRGARSSLSPDEHPQAPGLGSGYHPNTAYSGFPQAPAQSLQYQELISPAEG 291

  Fly   465 ---SSKPHHPRQHHSDHSPDAKRRIHKCQFLGCKKVYTKSSHLKAHQRTHTGEKPYKCSWEGCEW 526
               .|||...|:..    |..:...|.|.:.||.|.||||||||||.|||||||||.|.||||.|
Zfish   292 LPEESKPKRGRRSW----PRKRIATHTCDYAGCGKTYTKSSHLKAHHRTHTGEKPYHCDWEGCGW 352

  Fly   527 RFARSDELTRHYRKHTGAKPFKCRNCDRCFSRSDHLALHMKRHM 570
            :||||||||||||||||.:||:|..|||.||||||||||||||:
Zfish   353 KFARSDELTRHYRKHTGIRPFQCLKCDRAFSRSDHLALHMKRHL 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
luna	NP_001260879.1	COG5048	<455..>559	CDD:227381	62/106 (58%)
		C2H2 Zn finger	489..511	CDD:275368	15/21 (71%)
		zf-H2C2_2	503..>519	CDD:290200	14/15 (93%)
		C2H2 Zn finger	519..541	CDD:275368	18/21 (86%)
		zf-H2C2_2	533..558	CDD:290200	18/24 (75%)
		C2H2 Zn finger	549..569	CDD:275368	16/19 (84%)
klf4	NP_001106955.1	zf-C2H2	313..337	CDD:278523	16/23 (70%)
		C2H2 Zn finger	315..337	CDD:275368	15/21 (71%)
		COG5048	<320..>375	CDD:227381	45/54 (83%)
		C2H2 Zn finger	345..367	CDD:275368	18/21 (86%)
		zf-H2C2_2	359..384	CDD:290200	18/24 (75%)
		C2H2 Zn finger	375..395	CDD:275368	16/19 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585899
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.030