DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment luna and klf4

DIOPT Version :9

Sequence 1:	NP_001260879.1	Gene:	luna / 2768719	FlyBaseID:	FBgn0040765	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_001017280.1	Gene:	klf4 / 550034	XenbaseID:	XB-GENE-1015049	Length:	407	Species:	Xenopus tropicalis

Alignment Length:	447	Identity:	135/447 - (30%)
Similarity:	189/447 - (42%)	Gaps:	121/447 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 NMTPTSISNSSSISSS---------NSHSNSNGNTTGSSNIIASPLSSLGSGSTITVSSRNSSAP 208
            :||..|.|:|||:::|         ::.|..:..|......:..|..|  ||.|:..::|:.:.
Frog    51 SMTVGSSSSSSSVTASSPPPPATLPDTMSALSSTTCNFVYQVRCPQES--SGGTLMYNARDPTM- 112

  Fly   209 GIKVRVVQAKNHPGSNARMHLGHVQDFVLPTLTPPSSPESNLRSHNYAQQLEANDLAALIQQQQQ 273
                          |:|..:|..:.|.         ||     |..:..:|...||..:..|||.
Frog   113 --------------SSATFNLADINDV---------SP-----SGGFVAELMRPDLDPVFMQQQP 149

  Fly   274 QQQQQ---------QQQQQQQQLNPQPGNS---TPATAILRFTSQSNPTMTQLQQQQQQLAVQHL 326
            |...|         ......|.::.:..||   :|    |.:|:...|.:.|..:|:...:.  .
Frog   150 QASLQGKFVLKTTVSMGDYGQTISVRKNNSGIDSP----LSYTTHQLPRVCQKIKQEPSSSC--T 208

  Fly   327 SISP--------QALGHSNIGSNSPKSSSSSSSNSSNSSSSSHSSSSSISGSSDQPTHSNIPRST 383
            |..|        |::.....|...|..::.|.|.........||||.::|       ||::|
Frog   209 SACPMDGQGQQSQSMREFQAGRGLPIRTNQSLSPEELMGRDCHSSSQTLS-------HSSLP--- 263

  Fly   384 IVRLTTANGKPGAAGISLARVIQMQNNGNANVAAVLSAAANSGSSNSNSNSSSSNTSSNSINTAT 448
                     .|.|                                 .::::|.|:.:|:...|..
Frog   264 ---------IPPA---------------------------------YHTSASFSHFTSDQPQTQL 286

  Fly   449 PQQQVLSQRSEKSANGSSKPHHPRQHHSDHS-PDAKRRIHKCQFLGCKKVYTKSSHLKAHQRTHT 512
            |..|:  |..|....|...|...:......| |..:...|.|::.||.|.||||||||||.||||
Frog   287 PPTQL--QYQELLTTGGCIPEESKPKRGRKSWPRKRTATHTCEYAGCGKTYTKSSHLKAHLRTHT 349

  Fly   513 GEKPYKCSWEGCEWRFARSDELTRHYRKHTGAKPFKCRNCDRCFSRSDHLALHMKRH 569
            |||||.|.||||.|:||||||||||||||||.:||:|:.|||.||||||||||||||
Frog   350 GEKPYHCDWEGCGWKFARSDELTRHYRKHTGHRPFQCQRCDRAFSRSDHLALHMKRH 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
luna	NP_001260879.1	COG5048	<455..>559	CDD:227381	60/104 (58%)
		C2H2 Zn finger	489..511	CDD:275368	15/21 (71%)
		zf-H2C2_2	503..>519	CDD:290200	14/15 (93%)
		C2H2 Zn finger	519..541	CDD:275368	18/21 (86%)
		zf-H2C2_2	533..558	CDD:290200	18/24 (75%)
		C2H2 Zn finger	549..569	CDD:275368	16/19 (84%)
klf4	NP_001017280.1	zf-C2H2	324..348	CDD:333835	16/23 (70%)
		C2H2 Zn finger	326..348	CDD:275368	15/21 (71%)
		C2H2 Zn finger	356..378	CDD:275368	18/21 (86%)
		zf-H2C2_2	370..395	CDD:372612	18/24 (75%)
		C2H2 Zn finger	386..406	CDD:275368	16/19 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010