DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment luna and KLF3

DIOPT Version :9

Sequence 1:	NP_001260879.1	Gene:	luna / 2768719	FlyBaseID:	FBgn0040765	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_057615.3	Gene:	KLF3 / 51274	HGNCID:	16516	Length:	345	Species:	Homo sapiens

Alignment Length:	302	Identity:	111/302 - (36%)
Similarity:	144/302 - (47%)	Gaps:	60/302 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   314 LQQQQQQLAVQHLSISPQALGHSNIGSNSPKSSSSSSSNSSNSSSSSHSSSSSISGSSDQPTHSN 378
            :|.:...|.|...| ||.:.|:|......|.|...:|...|..|||......|......||  ..
Human    57 IQMEPVDLTVNKRS-SPPSAGNSPSSLKFPSSHRRASPGLSMPSSSPPIKKYSPPSPGVQP--FG 118

  Fly   379 IPRSTIVRLTTANGKPGAAGISLARVIQ--------------------------MQNNGNANVAA 417
            :|.|....:..|..:.|.....:..|||                          |:|:.::....
Human   119 VPLSMPPVMAAALSRHGIRSPGILPVIQPVVVQPVPFMYTSHLQQPLMVSLSEEMENSSSSMQVP 183

  Fly   418 VLSA----------AANSGSSNSNSNSSSSNTSSNSINTATPQQQVLSQRSEKSANGSSKPHHP- 471
            |:.:          ....|.....::......|...:|:.:|.|.:|.:            :||
Human   184 VIESYEKPISQKKIKIEPGIEPQRTDYYPEEMSPPLMNSVSPPQALLQE------------NHPS 236

  Fly   472 ------RQHHSDHSPDA--KRRIHKCQFLGCKKVYTKSSHLKAHQRTHTGEKPYKCSWEGCEWRF 528
                  ::.....|||.  |||||:|.:.||.||||||||||||:|||||||||||:||||.|:|
Human   237 VIVQPGKRPLPVESPDTQRKRRIHRCDYDGCNKVYTKSSHLKAHRRTHTGEKPYKCTWEGCTWKF 301

  Fly   529 ARSDELTRHYRKHTGAKPFKCRNCDRCFSRSDHLALHMKRHM 570
            |||||||||:|||||.|||:|.:|||.||||||||||.||||
Human   302 ARSDELTRHFRKHTGIKPFQCPDCDRSFSRSDHLALHRKRHM 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
luna	NP_001260879.1	COG5048	<455..>559	CDD:227381	65/112 (58%)
		C2H2 Zn finger	489..511	CDD:275368	16/21 (76%)
		zf-H2C2_2	503..>519	CDD:290200	14/15 (93%)
		C2H2 Zn finger	519..541	CDD:275368	17/21 (81%)
		zf-H2C2_2	533..558	CDD:290200	18/24 (75%)
		C2H2 Zn finger	549..569	CDD:275368	15/19 (79%)
KLF3	NP_057615.3	Repressor domain	1..74		6/17 (35%)
		KLF3_N	49..260	CDD:410554	42/217 (19%)
		9aaTAD, inactive. /evidence=ECO:0000269\|PubMed:31375868	60..68		2/7 (29%)
		CTBP-binding motif	61..65		0/3 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	66..112		14/46 (30%)
		zf-C2H2	260..284	CDD:395048	17/23 (74%)
		C2H2 Zn finger	262..284	CDD:275368	16/21 (76%)
		C2H2 Zn finger	292..314	CDD:275368	17/21 (81%)
		zf-H2C2_2	306..331	CDD:404364	18/24 (75%)
		C2H2 Zn finger	322..342	CDD:275368	15/19 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151400
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000436
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.940