DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment luna and Zfp352

DIOPT Version :9

Sequence 1:	NP_001260879.1	Gene:	luna / 2768719	FlyBaseID:	FBgn0040765	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_001102827.1	Gene:	Zfp352 / 502968	RGDID:	1563227	Length:	559	Species:	Rattus norvegicus

Alignment Length:	503	Identity:	121/503 - (24%)
Similarity:	191/503 - (37%)	Gaps:	132/503 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 ISSSNSHSNSNG------NTTGSSNIIASPLS-------------SLGSGSTITVSSRNSSAPGI 210
            :.|:..:.:..|      |:|.:| .:..||.             :|.|..|:.:.:.:.    .
  Rat    84 VVSAEQNKSPEGSLFMKLNSTATS-CLPQPLDTRKTLYNEGYWRRTLNSDKTLLIQNTDL----C 143

  Fly   211 KVRVVQAKNHP----GSNARM-----HLGHVQDFVL-PTLTPPSSP------------------E 247
            :.:.:...|||    ||:|..     ||..|.|... ..|..|.|.                  |
  Rat   144 ESQRITFGNHPVALSGSHAGQVPNVDHLDSVWDQTFGGDLEMPFSDDSYYSQMTTKYGGHLTLYE 208

  Fly   248 SNLRSHNYAQQLEANDLAALIQQQQQQQQQQQQQQQQQQL---------------NPQ-PGNSTP 296
            |.:.:.:..|.|:.:.......:|.....||:....:.:.               .|| ..||..
  Rat   209 SQMIAPSCNQVLDTDQFVTSFYEQNPFGDQQRSPVTENKFYGDQMIVPNAYQAFYEPQVRDNSDQ 273

  Fly   297 ATAILRFTSQSNPTMTQLQQQ------------------QQQLAVQHLSISPQALGHSNIGSNSP 343
            .....|..|.|...:...|:.                  .|...:.|..|||.. |.:...|..|
  Rat   274 INFDSRMASFSGQNICSGQESIFQDEHSLSGFQTSGYRCDQDWIMNHQVISPIG-GQTLYDSQKP 337

  Fly   344 KSSSSSSSNSSNSSSSS-------HSSSSSISGSSDQPTHSNIPRSTIVRLTTANGKPGAAGISL 401
            .|:.:::.:.|..::||       |..:||   ||::..:.                 |....|:
  Rat   338 TSTFNTTPHGSKRTTSSAEDNLAWHPETSS---SSEETLYM-----------------GQMRASV 382

  Fly   402 ARVIQMQNNGNANVAAVLSAAANSGSSNSNSNSSSSNTSSNSINTATPQQQVLSQRSEKSANGSS 466
            .:.:....||.||....|.....|.|:.:.....||::||      :|..::.|| ...||:|..
  Rat   383 DQNVYASQNGTANTEESLEPEVTSLSNQAPDVGESSDSSS------SPLIRIQSQ-GISSASGLD 440

  Fly   467 KPHHPR-----QHHSDHSPD----AKRRIHKCQFLGCKKVYTKSSHLKAHQRTHTGEKPYKCSWE 522
            :..||:     :..|..||:    .||  :.|.:.||:|.||||.|||.|.|.||||||:.|...
  Rat   441 QGQHPQIRLDLKTQSPVSPEKPPTLKR--YSCTYQGCEKSYTKSHHLKDHMRKHTGEKPFVCDQI 503

  Fly   523 GCEWRFARSDELTRHYRKHTGAKPFKCRNCDRCFSRSDHLALHMKRHM 570
            ||.|:|.||.:|.||.:||:|.:|:.|..|::.:||..:|..|...|:
  Rat   504 GCNWKFFRSIDLNRHKKKHSGERPYACPKCNKNYSRPYYLKQHQVSHI 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
luna	NP_001260879.1	COG5048	<455..>559	CDD:227381	48/112 (43%)
		C2H2 Zn finger	489..511	CDD:275368	13/21 (62%)
		zf-H2C2_2	503..>519	CDD:290200	11/15 (73%)
		C2H2 Zn finger	519..541	CDD:275368	10/21 (48%)
		zf-H2C2_2	533..558	CDD:290200	9/24 (38%)
		C2H2 Zn finger	549..569	CDD:275368	6/19 (32%)
Zfp352	NP_001102827.1	zf-C2H2	468..492	CDD:278523	13/23 (57%)
		C2H2 Zn finger	470..492	CDD:275368	13/21 (62%)
		zf-H2C2_2	484..>502	CDD:290200	12/17 (71%)
		C2H2 Zn finger	500..522	CDD:275368	10/21 (48%)
		zf-H2C2_2	514..539	CDD:290200	9/24 (38%)
		C2H2 Zn finger	530..550	CDD:275368	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344910
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030