DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment luna and sr

DIOPT Version :9

Sequence 1:	NP_001260879.1	Gene:	luna / 2768719	FlyBaseID:	FBgn0040765	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_001262693.1	Gene:	sr / 42162	FlyBaseID:	FBgn0003499	Length:	1271	Species:	Drosophila melanogaster

Alignment Length:	736	Identity:	172/736 - (23%)
Similarity:	245/736 - (33%)	Gaps:	254/736 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SELERICTTGYYSSQPSIEDQWQQTCYELERYLRDEPKLQKKMHSNLDNP----WDI--FSTPAR 69
            |.|..:.|:|.:|...|..:|           :....:|.:.:..:|:.|    .||  |..|..
  Fly   430 SHLSLLNTSGQHSPTSSAVEQ-----------VEAHKQLIEALPGDLNTPVTTSSDIPSFFGPTT 483

  Fly    70 LL-----------EELKIKEQHLDTISTTSSVSSNCSGTSWDSNGSQALSCSVLVKQERIDEEDD 123
            ::           |:|.::.|   .||..|.|.|:||.                :|:||
  Fly   484 VVEPPPITGSIESEDLSLEPQ---VISVASPVLSHCSP----------------LKEER------ 523

  Fly   124 DVGCDDKLSVLLAAPPS-AISPNPSIGSAGNMTPTSISNSSSISSSNSHSNSNGNTTGSSNIIAS 187
                        :.||: ||....|..::.||.|          ..|:::|:|.|||.||....|
  Fly   524 ------------STPPALAIVKEESSNNSCNMYP----------QHNNNNNNNNNTTSSSTTTTS 566

  Fly   188 PLSS-------LGSGSTITVSSRNSSAPGIKVRVVQAKNHPGSNARMHLGHVQDFVLPTLTPPSS 245
            ..::       :||....|.|.:...      :.:|..|...||:..|..|.|..........||
  Fly   567 KQTTSESNTECVGSPGNHTQSHQQQQ------QQLQHNNTSSSNSNCHHSHQQQQQQQQQQHMSS 625

  Fly   246 PESNLRSHNYAQQLEA---------------NDLAALIQQQQQQQQQQQQQQ----QQQQLNPQ- 290
            |:...:.|....|.:.               :.|..|.|||||||||||.||    |||||..|
  Fly   626 PQQQYQQHQILHQQQQLPNHHHHHHHHHHHHSQLQQLQQQQQQQQQQQQHQQQPLHQQQQLQHQQ 690

  Fly   291 ----------------------------------PGNSTPATAILRFTSQSNPTMTQLQQQQQ-- 319
                                              .||:..|.|.....:.......|.|.|||
  Fly   691 QQQHHQQHYQQHAIQHQQSQQQASKISYRGIFTTTGNAMNAAAAAAAAAAQQQHQQQQQHQQQLP 755

  Fly   320 --QLAVQHLSISP--QALGHSNIGSNSPKS--------------SSSSSSNSSNSSSSSHSSSSS 366
              ||.|....:||  .:||:| .|..||..              ::...................
  Fly   756 SPQLGVLAGPMSPPSNSLGNS-WGLPSPDKTMFQPPLFSLPAHYATMQQQQQQQQQQQQQQQQQQ 819

  Fly   367 ISGSSDQP------------THSNIPRSTI--VRLTTANGKPGAAGISLA--------------- 402
            .:|::..|            .|:.:...|:  ..|......|..||.|..
  Fly   820 AAGAAPSPYDDGRAAAAAAAQHAELLGLTMDCTPLLLKQPPPSYAGASAGFPGLGDLHSSHEQQL 884

  Fly   403 --------------------------RVIQMQNNGNANVAAVL----SAAANSG----------- 426
                                      :|.|:|.........||    |:|::|.
  Fly   885 QQQQYVRSQPKYQWLDSPADYAQQQQQVQQVQQQQQQQQTLVLPGPTSSASSSNAALGVLIPKQE 949

  Fly   427 -------SSNSNSNSSSSNTSSNSINTATPQQQVLSQRSEKSANGSSKPHHPRQHHSDHSPDAKR 484
                   |||....|..|..||.:...|........|.:|.|.: :||.|           :...
  Fly   950 NYPDMQPSSNGTGYSGGSGGSSAAAAAAAAAAAAAVQLAEYSPS-TSKGH-----------EILS 1002

  Fly   485 RIHKCQFLGCKKVYTK-SSHLKAHQRTHTGEKPYKCSWEGCEWRFARSDELTRHYRKHTGAKPFK 548
            ::::...:..|.|..| ..:.....:|...|:||.|..|.|:.||:||||||||.|.|||.|||:
  Fly  1003 QVYQQSTVPLKLVPVKPRKYPNRPSKTPVHERPYACPVENCDRRFSRSDELTRHIRIHTGQKPFQ 1067

  Fly   549 CRNCDRCFSRSDHLALHMKRH 569
            ||.|.|.|||||||..|::.|
  Fly  1068 CRICMRSFSRSDHLTTHIRTH 1088

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
luna	NP_001260879.1	COG5048	<455..>559	CDD:227381	39/104 (38%)
		C2H2 Zn finger	489..511	CDD:275368	3/22 (14%)
		zf-H2C2_2	503..>519	CDD:290200	4/15 (27%)
		C2H2 Zn finger	519..541	CDD:275368	14/21 (67%)
		zf-H2C2_2	533..558	CDD:290200	17/24 (71%)
		C2H2 Zn finger	549..569	CDD:275368	12/19 (63%)
sr	NP_001262693.1	zf-C2H2	1036..1060	CDD:278523	15/23 (65%)
		C2H2 Zn finger	1038..1060	CDD:275368	14/21 (67%)
		zf-H2C2_2	1052..1077	CDD:290200	17/24 (71%)
		C2H2 Zn finger	1068..1088	CDD:275368	12/19 (63%)
		zf-H2C2_2	1080..1105	CDD:290200	4/9 (44%)
		C2H2 Zn finger	1096..1116	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010