DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment luna and Sp9

DIOPT Version :9

Sequence 1:	NP_001260879.1	Gene:	luna / 2768719	FlyBaseID:	FBgn0040765	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_001178831.1	Gene:	Sp9 / 366078	RGDID:	1559457	Length:	485	Species:	Rattus norvegicus

Alignment Length:	473	Identity:	128/473 - (27%)
Similarity:	192/473 - (40%)	Gaps:	97/473 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 SVLLAAPPSAISPNPSIGSA----GNMTP-TSISNSSSISSSNSH----SNSNGNTTGSSNIIAS 187
            |:|...|....:|...:.:.    ||.:| |::..||:.:....|    |:|:.|...|.:..|.
  Rat     4 SILGEEPRFGTTPLAMLAATCNKIGNTSPLTTLPESSAFAKGGFHPWKRSSSSCNLGSSLSGFAV 68

  Fly   188 PLSSLGSGSTITVSSRNSSAPGIKVRVVQAKNHPGSNARMHLGHVQDFVLPTLTPPSSPESNLRS 252
            .....||||....|...:||                           |.|.:.:|.||..|:...
  Rat    69 ATGGRGSGSLAGGSGAANSA---------------------------FCLASTSPTSSAFSSDYG 106

  Fly   253 HNYAQQLEANDLAALIQQQQQQQQ----QQQQQQQQQQLNPQPGNSTP----------------- 296
            ..::....|...||.:..|:...|    .:........|.|:.|.:.|
  Rat   107 GLFSNSAAAAAAAAGVSPQEAGGQSAFISKVHTTAADGLYPRVGMAHPYESWYKSGFHSTLAAGE 171

  Fly   297 ---ATAILRFTSQSNP-TMTQLQQQQQQLAVQHLSISPQALGHSNIGSNSPKSSSSSSSNSSNSS 357
               ..|...:...|:| :..::|.....|.....|.:|||..||.:|:.:|           :.|
  Rat   172 VTNGAASSWWDVHSSPGSWLEVQNPAGGLQSSLHSGAPQASLHSQLGTYNP-----------DFS 225

  Fly   358 SSSHSSSSSISGSSDQPTHSNIPRSTIVRLTTANG-KPGAAGISLARVIQMQNNGNANVAAVLSA 421
            |.:||:.||....|.....|:: .||...|...:| ||         |:...::.:|.|||..::
  Rat   226 SLTHSAFSSTGLGSSAAAASHL-LSTSQHLLAQDGFKP---------VLPSYSDSSAAVAAAAAS 280

  Fly   422 AANSGSSNSNSNSSSSNTSSNSINTATPQQQVLSQRSEKSANGSSKPHHPRQHHSDHSPDAKRRI 486
            |..||::.:.:..||:.::......||.......:.......|:|.              .::.:
  Rat   281 AMISGAAAAAAGGSSARSARRYSGRATCDCPNCQEAERLGPAGASL--------------RRKGL 331

  Fly   487 HKCQFLGCKKVYTKSSHLKAHQRTHTGEKPYKCSWEGCEWRFARSDELTRHYRKHTGAKPFKCRN 551
            |.|...||.|||.|:||||||.|.||||:|:.|:|..|..||.|||||.||.|.|||.|.|.|..
  Rat   332 HSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPV 396

  Fly   552 CDRCFSRSDHLALHMKRH 569
            |::.|.|||||:.|:|.|
  Rat   397 CNKRFMRSDHLSKHIKTH 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
luna	NP_001260879.1	COG5048	<455..>559	CDD:227381	43/103 (42%)
		C2H2 Zn finger	489..511	CDD:275368	14/21 (67%)
		zf-H2C2_2	503..>519	CDD:290200	11/15 (73%)
		C2H2 Zn finger	519..541	CDD:275368	13/21 (62%)
		zf-H2C2_2	533..558	CDD:290200	13/24 (54%)
		C2H2 Zn finger	549..569	CDD:275368	10/19 (53%)
Sp9	NP_001178831.1	SP6-9_N	19..333	CDD:425402	75/375 (20%)
		C2H2 Zn finger	337..356	CDD:275368	13/18 (72%)
		zf-H2C2_2	348..375	CDD:404364	16/26 (62%)
		C2H2 Zn finger	364..386	CDD:275368	13/21 (62%)
		zf-H2C2_2	378..401	CDD:404364	12/22 (55%)
		zf-C2H2	392..414	CDD:395048	11/21 (52%)
		C2H2 Zn finger	394..414	CDD:275368	10/19 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344914
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.930