DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment luna and wt1a

DIOPT Version :9

Sequence 1:	NP_001260879.1	Gene:	luna / 2768719	FlyBaseID:	FBgn0040765	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_571121.1	Gene:	wt1a / 30245	ZFINID:	ZDB-GENE-980526-558	Length:	419	Species:	Danio rerio

Alignment Length:	451	Identity:	105/451 - (23%)
Similarity:	159/451 - (35%)	Gaps:	134/451 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 GNTTGSSNIIASPLSSLGSGS---TITVSSRNSSAPGIKVRVVQAKNHPGSNARMHLGHVQDFVL 237
            |:.....|.:..|:..|..|:   |:.|||.....|.:.               .|.|
Zfish     2 GSDVRDLNTLLPPVPPLPGGNGNCTLPVSSTPQWPPMLD---------------FHTG------- 44

  Fly   238 PTLTPPSSPESNLRSHNYAQQLEANDLAALIQQQQQQQQQQQQQQQQQQLNPQPGNSTP------ 296
                   :|..:|..|::.:|                             .|..|.:.|
Zfish    45 -------APYGSLAQHSFIKQ-----------------------------EPSWGTADPHEDPHC 73

  Fly   297 --------------ATAILRFTSQSNPTMTQLQQQQQQLAVQHLSISPQALGHSNIGSNSPKSSS 347
                          .|...|:.:...|..:|....|           |:...:|...||...|.|
Zfish    74 GLSAFTVHFSGQFTGTGACRYGAFGAPAASQPPPSQ-----------PRMFSNSPYLSNCMDSQS 127

  Fly   348 SSSSNS------SNSSSSSHSSSSSISGSSDQPTHSNIPRSTIVRLTTANGK-----PGAAGI-- 399
            ||.:..      ..:|:..|:.|..   :...|.||.....:|.:.:....:     |...|.
Zfish   128 SSRNQGYGTVAFDGASNYGHTPSHH---TPQFPNHSFKHEDSITQQSNMGDQQYPVPPPVYGCHT 189

  Fly   400 -------SLARVIQMQNNGNANVAAVLSAAANSGSSNSNSNSSS--SNTSSNSINTATPQQQVLS 455
                   |.|.:::...|.:.|:..:.|.....|.:..||.:|:  |:......:.:||.....|
Zfish   190 PSDSCTGSQALLLRNPYNSSDNLYQMASQLECMGWNPVNSLASTIKSHPGGYESDPSTPMVYSCS 254

  Fly   456 QRSEKSANGSSK------------PHHPRQHHSDHSPDAKRRIHKCQFLGCKKVYTKSSHLKAHQ 508
            .:.....:|..:            |...|...::     ::|...|.:.||.|.|.|.|||:.|.
Zfish   255 TQYRIHTHGVFRGLQDVRRVPGITPAIVRSTETN-----EKRPFMCAYPGCNKRYFKLSHLQMHS 314

  Fly   509 RTHTGEKPYKCSWEGCEWRFARSDELTRHYRKHTGAKPFKCRNCDRCFSRSDHLALHMKRH 569
            |.|||||||:|.:..|..||:|||:|.||.|:|||.|||:|..|.|.|||||||..|.:.|
Zfish   315 RKHTGEKPYQCDFTDCGRRFSRSDQLKRHQRRHTGVKPFQCETCQRKFSRSDHLKTHTRTH 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
luna	NP_001260879.1	COG5048	<455..>559	CDD:227381	45/115 (39%)
		C2H2 Zn finger	489..511	CDD:275368	11/21 (52%)
		zf-H2C2_2	503..>519	CDD:290200	11/15 (73%)
		C2H2 Zn finger	519..541	CDD:275368	11/21 (52%)
		zf-H2C2_2	533..558	CDD:290200	14/24 (58%)
		C2H2 Zn finger	549..569	CDD:275368	11/19 (58%)
wt1a	NP_571121.1	WT1	1..291	CDD:280348	57/365 (16%)
		COG5048	286..>411	CDD:227381	48/95 (51%)
		C2H2 Zn finger	298..317	CDD:275368	10/18 (56%)
		zf-H2C2_2	309..336	CDD:290200	15/26 (58%)
		C2H2 Zn finger	325..347	CDD:275368	11/21 (52%)
		zf-H2C2_2	340..364	CDD:290200	14/23 (61%)
		C2H2 Zn finger	355..375	CDD:275368	11/19 (58%)
		C2H2 Zn finger	386..408	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.100