DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment luna and Wt1

DIOPT Version :9

Sequence 1:	NP_001260879.1	Gene:	luna / 2768719	FlyBaseID:	FBgn0040765	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_113722.2	Gene:	Wt1 / 24883	RGDID:	3974	Length:	448	Species:	Rattus norvegicus

Alignment Length:	492	Identity:	118/492 - (23%)
Similarity:	173/492 - (35%)	Gaps:	158/492 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 GCDDKLS-------VLLAAPPSAISPNPSIGSAGNMTP------------TSISNSSSISSSNSH 171
            ||...:|       ||..|||.|    .:.||.|...|            :.|....|...:..|
  Rat    23 GCGLPVSGAAQWAPVLDFAPPGA----SAYGSLGGPAPPPAPPPPPPPPHSFIKQEPSWGGAEPH 83

  Fly   172 SNS---------NGNTTGSSNII------ASPLSSLGSG------STITVSSRNSSAPGIKVRVV 215
            ...         :|..||::...      ..|.|...||      :...:.|...|.|.|:.:..
  Rat    84 EEQCLSAFTLHFSGQFTGTAGACRYGPFGPPPPSQASSGQARMFPNAPYLPSCLESQPSIRNQGY 148

  Fly   216 QAKNHPGSNARMHLGHVQDFVLPTLTPPSSPESNLRSHNYAQQLEANDLAALIQQQQQQQQQQQQ 280
            ......|:.:   .||.          ||...:...:|::              :.:....||..
  Rat   149 STVTFDGAPS---YGHT----------PSHHAAQFPNHSF--------------KHEDPMGQQGS 186

  Fly   281 QQQQQQLNPQP--GNSTP------ATAILRFTSQSNPTMTQLQQQQQQLAVQHLSISPQALGHSN 337
            ..:||...|.|  |..||      :.|:|..|..|:..:.|:..|.:.:....:::.....|.:.
  Rat   187 LGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLGATLKGMAA 251

  Fly   338 IGSNSPKSSSSSSSNSSNSSSSSHSSSSSISGSSDQPTHSNIPRSTIVRLTTANGKPGAAGISLA 402
            ..|:|.|.:...|::.:...|.:|::...........||.      :.|           ||...
  Rat   252 GSSSSVKWTEGQSNHGTGYESENHTTPILCGAQYRIHTHG------VFR-----------GIQDV 299

  Fly   403 RVIQMQNNGNANVAAVLSAAANSGSSNSNSNSSSSNTSSNSINTATPQQQVLSQRSEKSANGSSK 467
            |.:       :.||..|..:|                               |:.|||
  Rat   300 RRV-------SGVAPTLVRSA-------------------------------SETSEK------- 319

  Fly   468 PHHPRQHHSDHSPDAKRRIHKCQFLGCKKVYTKSSHLKAHQRTHTGEKPYKCSWEGCEWRFARSD 532
                             |...|.:.||.|.|.|.|||:.|.|.|||||||:|.::.||.||:|||
  Rat   320 -----------------RPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSD 367

  Fly   533 ELTRHYRKHTGAKPFKCRNCDRCFSRSDHLALHMKRH 569
            :|.||.|:|||.|||:|:.|.|.|||||||..|.:.|
  Rat   368 QLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTH 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
luna	NP_001260879.1	COG5048	<455..>559	CDD:227381	46/103 (45%)
		C2H2 Zn finger	489..511	CDD:275368	11/21 (52%)
		zf-H2C2_2	503..>519	CDD:290200	11/15 (73%)
		C2H2 Zn finger	519..541	CDD:275368	12/21 (57%)
		zf-H2C2_2	533..558	CDD:290200	14/24 (58%)
		C2H2 Zn finger	549..569	CDD:275368	11/19 (58%)
Wt1	NP_113722.2	WT1	1..320	CDD:280348	69/406 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..83		6/34 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	166..186		3/33 (9%)
		9aaTAD. /evidence=ECO:0000250\|UniProtKB:P19544	235..243		0/7 (0%)
		COG5048	312..>440	CDD:227381	54/148 (36%)
		C2H2 Zn finger	327..346	CDD:275368	10/18 (56%)
		zf-H2C2_2	338..365	CDD:290200	16/26 (62%)
		C2H2 Zn finger	354..376	CDD:275368	12/21 (57%)
		Important for interaction with target DNA. /evidence=ECO:0000250	366..380		9/13 (69%)
		zf-H2C2_2	369..393	CDD:290200	14/23 (61%)
		C2H2 Zn finger	384..404	CDD:275368	11/19 (58%)
		Important for interaction with target DNA. /evidence=ECO:0000250	392..400		6/7 (86%)
		KTS motif. /evidence=ECO:0000250	407..409
		C2H2 Zn finger	415..437	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100