DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment luna and KLF14

DIOPT Version :9

Sequence 1:	NP_001260879.1	Gene:	luna / 2768719	FlyBaseID:	FBgn0040765	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_619638.2	Gene:	KLF14 / 136259	HGNCID:	23025	Length:	323	Species:	Homo sapiens

Alignment Length:	283	Identity:	93/283 - (32%)
Similarity:	117/283 - (41%)	Gaps:	60/283 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   289 PQPGNSTPATAILRFTSQSNPTMTQLQQQQQQLAVQHLSISPQALGHSNIGSNSPKSSSSSSSNS 353
            |.||...||         |.|.:.|:........    ..:|..|..|........|...|..||
Human    53 PGPGPPGPA---------SVPQLPQVPAPSPGAG----GAAPHLLAASVWADLRGSSGEGSWENS 104

  Fly   354 SNSSSSSHSSSSSISGSSDQPTHSNIPRSTIVRLTTANGKPGAAGISLARVIQMQNNGNANVAAV 418
            ..:..:|...|..|..|...|.....|.|            |||.:...       ..:::..||
Human   105 GEAPRASSGFSDPIPCSVQTPCSELAPAS------------GAAAVCAP-------ESSSDAPAV 150

  Fly   419 LSAAANSGSSNSNSNSSSSNTSSNSINT--ATPQQQVLSQRSEKSANGSSKPHHPRQHHSDHSPD 481
            .||.|..|:.     ::|...|..::..  |....|...:||.                   :|.
Human   151 PSAPAAPGAP-----AASGGFSGGALGAGPAPAADQAPRRRSV-------------------TPA 191

  Fly   482 AKRRIHKCQFLGCKKVYTKSSHLKAHQRTHTGEKPYKCSWEGCEWRFARSDELTRHYRKHTGAKP 546
            |||  |:|.|.||.|.|.||||||:||||||||:|:.|.|..|:.:|.|||||.||||.|||.|.
Human   192 AKR--HQCPFPGCTKAYYKSSHLKSHQRTHTGERPFSCDWLDCDKKFTRSDELARHYRTHTGEKR 254

  Fly   547 FKCRNCDRCFSRSDHLALHMKRH 569
            |.|..|.:.|||||||..|.:||
Human   255 FSCPLCPKQFSRSDHLTKHARRH 277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
luna	NP_001260879.1	COG5048	<455..>559	CDD:227381	50/103 (49%)
		C2H2 Zn finger	489..511	CDD:275368	15/21 (71%)
		zf-H2C2_2	503..>519	CDD:290200	12/15 (80%)
		C2H2 Zn finger	519..541	CDD:275368	13/21 (62%)
		zf-H2C2_2	533..558	CDD:290200	14/24 (58%)
		C2H2 Zn finger	549..569	CDD:275368	10/19 (53%)
KLF14	NP_619638.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..80		8/39 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..116		5/21 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	142..161		6/23 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	166..195		9/49 (18%)
		COG5048	198..>283	CDD:227381	50/80 (63%)
		C2H2 Zn finger	200..219	CDD:275368	13/18 (72%)
		C2H2 Zn finger	227..249	CDD:275368	13/21 (62%)
		C2H2 Zn finger	257..277	CDD:275368	10/19 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	279..323
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151422
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840