DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment luna and KLF12

DIOPT Version :9

Sequence 1:	NP_001260879.1	Gene:	luna / 2768719	FlyBaseID:	FBgn0040765	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	XP_011533209.1	Gene:	KLF12 / 11278	HGNCID:	6346	Length:	415	Species:	Homo sapiens

Alignment Length:	459	Identity:	152/459 - (33%)
Similarity:	204/459 - (44%)	Gaps:	141/459 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 DDKLSV---LLAAPPSAISPNPSIGS--AGNMTPTSISNSSSISSSNSHSNSNGNTTGSSNIIAS 187
            :|.|||   .....|..:|.|.:..|  |.:.:|.|::.|:|..||.|.|:|:.:...||..:.:
Human    80 EDSLSVDHFQTQTEPVDLSINKARTSPTAVSSSPVSMTASASSPSSTSTSSSSSSRLASSPTVIT 144

  Fly   188 PLSSLGSGSTI-TVSSRNSSAPGIKVRVVQAKNHPGSNARMHLGHVQDFVLPTLTPPSSP---ES 248
            .:||..|.||: |.....:||.|:           |....:|:.|.        .|||||   :|
Human   145 SVSSASSSSTVLTPGPLVASASGV-----------GGQQFLHIIHP--------VPPSSPMNLQS 190

  Fly   249 NLRSHNYAQQLEANDLAALIQQQQQQQQQQQQQQQQQQLNPQPGNSTPA--TAILRFTSQSNPTM 311
            |..||       .:.:..::|                        |.|.  ||:....:.:|..:
Human   191 NKLSH-------VHRIPVVVQ------------------------SVPVVYTAVRSPGNVNNTIV 224

  Fly   312 TQLQQQQQQLAVQHLSISPQALGHSNIGSN----SPKSSSSSSSNSSNSSSSSHSSSSSISGSSD 372
            ..|.:..:              ||.....:    ||:.|.|.|.:                  .|
Human   225 VPLLEDGR--------------GHGKAQMDPRGLSPRQSKSDSDD------------------DD 257

  Fly   373 QPTHSNIPRSTIVRLTTANGKPGAAGISLARVIQMQNNGNANVAAVLSAAANSGSSNSNSNSSSS 437
            .|.         |.|.:.| :.|:..:|:||.:|..:                       .|..|
Human   258 LPN---------VTLDSVN-ETGSTALSIARAVQEVH-----------------------PSPVS 289

  Fly   438 NTSSNSINTATPQQQVLSQRSEKSANGSSKPHHPRQHHSDHSPDA-KRRIHKCQFLGCKKVYTKS 501
            ....|.:|         :|:...|.:..|.....||..|: |||: |||||:|.|.||.||||||
Human   290 RVRGNRMN---------NQKFPCSISPFSIESTRRQRRSE-SPDSRKRRIHRCDFEGCNKVYTKS 344

  Fly   502 SHLKAHQRTHTGEKPYKCSWEGCEWRFARSDELTRHYRKHTGAKPFKCRNCDRCFSRSDHLALHM 566
            ||||||:|||||||||||:||||.|:||||||||||||||||.|||||.:|||.||||||||||.
Human   345 SHLKAHRRTHTGEKPYKCTWEGCTWKFARSDELTRHYRKHTGVKPFKCADCDRSFSRSDHLALHR 409

  Fly   567 KRHM 570
            :|||
Human   410 RRHM 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
luna	NP_001260879.1	COG5048	<455..>559	CDD:227381	72/104 (69%)
		C2H2 Zn finger	489..511	CDD:275368	17/21 (81%)
		zf-H2C2_2	503..>519	CDD:290200	14/15 (93%)
		C2H2 Zn finger	519..541	CDD:275368	18/21 (86%)
		zf-H2C2_2	533..558	CDD:290200	20/24 (83%)
		C2H2 Zn finger	549..569	CDD:275368	14/19 (74%)
KLF12	XP_011533209.1	COG5048	<241..414	CDD:227381	102/234 (44%)
		zf-C2H2	330..354	CDD:278523	18/23 (78%)
		C2H2 Zn finger	332..354	CDD:275368	17/21 (81%)
		zf-H2C2_2	346..>363	CDD:290200	15/16 (94%)
		C2H2 Zn finger	362..384	CDD:275368	18/21 (86%)
		zf-H2C2_2	376..401	CDD:290200	20/24 (83%)
		C2H2 Zn finger	392..412	CDD:275368	14/19 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151405
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940