DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir41a and grik5

DIOPT Version :9

Sequence 1:	NP_995744.4	Gene:	Ir41a / 2768714	FlyBaseID:	FBgn0040849	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_001315085.1	Gene:	grik5 / 798791	ZFINID:	ZDB-GENE-070821-6	Length:	1067	Species:	Danio rerio

Alignment Length:	478	Identity:	106/478 - (22%)
Similarity:	169/478 - (35%)	Gaps:	96/478 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 SLFADKLNNLQGREVIIAGFDYPPYTVIKHNMSTNAQDMGVSGESDFKNVYIDG-TETRIVLNFC 262
            ||..:....|..:.:||......||.:.|    .|.|:.  .|...::...:|. .|...:|.|
Zfish   416 SLDINVSETLANKSLIITTILENPYVMRK----INYQEF--EGNEQYEGFCVDMLRELSDILKF- 473

  Fly   263 EQFNCTIQIDSSAANDWGKVYPNMSGDGALGMLINRKADICIGAMYSWYEDYTYLDLSMYLVRSG 327
                 |.:|.......:|...||.|..|.:|.|||||||:.:.|.....|....:|.|...:..|
Zfish   474 -----TYRIKLVDDGLYGAPEPNGSWTGMVGELINRKADLAVAAFTITSEREKVIDFSKPFMTLG 533

  Fly   328 ITCLVPAPL-RLTSWYLPLEPFKETLWAAILLCLCAEATGLVLA--------YKSEQALYVLPGY 383
            |:.|....: |...::..|:||...:|..:||...|.:..|.|:        |.....|......
Zfish   534 ISILYRVHIGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLSARLSPYEWYNPHPCLRERRDL 598

  Fly   384 REGWWTCTSFGVCTTFKL--FISQSGNSKAYSLTVRVLLFACFLNDLIITSIYGGGLASILTIPS 446
            .|..:|   .|....|.:  |:.|.......:|:.|.:....:...|||.|.|...||:.||:..
Zfish   599 LENQYT---LGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQR 660

  Fly   447 M-------DEAAD-------------TVT-----RLRFHRLQWAANSEAWVSA-IRASDEALVKD 485
            |       |:.||             |:|     |.:.::..|........|. :::::|.:.:.
Zfish   661 MEVPIESPDDLADQTNIQYGTIHGGSTMTFFMNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARV 725

  Fly   486 I--LYNFHIYSD-DELLRLAQDQHMRIGFTVERLPFGHFAIGNYLGPQAIDQLVIMKDDIYFQYT 547
            :  .|.|.:.|. :|..|.......:||..::...:|   ||..||....|:|.:....:.....
Zfish   726 VNSKYAFLLESTMNEYHRSLNCNLTQIGGLLDTKGYG---IGMPLGSPFRDELSLAVLQLQENNR 787

  Fly   548 VAFVPRLWPLLDKLNTLIYSWHSSGFDKYWEYRVVADNLNLKIQQQVQETMTGTKDIGPVPLGMS 612
            :..:.|.|            |......|..::|...                         |||.
Zfish   788 LEILKRRW------------WEGGKCPKEEDHRAKG-------------------------LGME 815

  Fly   613 NFAGFIIVWILGSAIATLTFLLE 635
            |..|..:|.|.|..||....::|
Zfish   816 NIGGIFVVLICGLIIAVFVAVME 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir41a	NP_995744.4	None
grik5	NP_001315085.1	PBP1_iGluR_Kainate_KA1_2	38..412	CDD:107389
		ANF_receptor	55..392	CDD:279440
		Periplasmic_Binding_Protein_Type_1	<313..383	CDD:299141
		Periplasmic_Binding_Protein_Type_2	427..797	CDD:304360	89/399 (22%)
		Lig_chan	558..828	CDD:278489	61/312 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591751
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840