DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir41a and gria1a

DIOPT Version :9

Sequence 1:	NP_995744.4	Gene:	Ir41a / 2768714	FlyBaseID:	FBgn0040849	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_991161.1	Gene:	gria1a / 798689	ZFINID:	ZDB-GENE-020125-1	Length:	914	Species:	Danio rerio

Alignment Length:	504	Identity:	94/504 - (18%)
Similarity:	170/504 - (33%)	Gaps:	135/504 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 LQGREVIIAGFDYPPYTVIKHNMSTNAQDMGVSGESDFKNVYIDGTETRIVLNFCEQFNCTIQID 272
            ||.|..|:......||.::|.|..      ..:|...::             .:|      :::.
Zfish   402 LQNRTYIVTTILESPYVMLKKNHE------HFTGNDKYE-------------GYC------VELA 441

  Fly   273 SSAANDWGKVY---------------PNMSGDGALGMLINRKADICIGAMYSWYEDYTYLDLSMY 322
            :..|...|..|               ..|..:|.:|.|:..|||:.:..:.........:|.|..
Zfish   442 AEIAKHVGYHYILKIVADGKYGARDAETMMWNGMVGELVYGKADVAVAPLTITLVREEVIDFSKP 506

  Fly   323 LVRSGITCLVPAPLRLTSWYLP-LEPFKETLWAAILLCLCAEATGLVLAYK-------------- 372
            .:..||:.::..|.:....... |:|....:|..|:......:..|.|..:
Zfish   507 FMSLGISIMIKKPTKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHADDCEDG 571

  Fly   373 ------SEQALYVLPGY------REGWWTCTSFGVCTT--FKL--FISQSGNSKAYSLTVRVLLF 421
                  ...:....||.      ::.......||:..:  |.|  |:.|..:....||:.|::..
Zfish   572 AEENPNQPSSSSAQPGQNQQNQNQQSQEQTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGG 636

  Fly   422 ACFLNDLIITSIYGGGLASILTIPSM----DEAADTV--------------TRLRFHRLQWAANS 468
            ..:...|||.|.|...||:.||:..|    :.|.|..              |:..|.|.:.|...
Zfish   637 VWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDAGSTKEFFRRSKIAVFE 701

  Fly   469 EAWVSAIRASDEALVKDILYNFHIYSDDELLRLAQDQHMRIGFTVE---------RLPFGHFAIG 524
            :.| |.::::|.::       |...:|:.::|:.:.:. :..:.:|         |.|.....:|
Zfish   702 KMW-SYMKSADPSV-------FVKTTDEGVMRVRKSKG-KYAYLLESTMNEYIEQRKPCDTMKVG 757

  Fly   525 NYLGPQAIDQLVIMKDDIYFQYTVAFVPRLWPLLDKLNTLIYSWHSSGFDKYWEYRVVADNLNLK 589
            ..|..:.              |.:| .|:..||.:.:|..:...:..|         :.|.|..|
Zfish   758 GNLDSKG--------------YGIA-TPKGSPLRNPVNLAVLKLNEQG---------LLDKLKNK 798

  Fly   590 IQQQVQETMTG---TKDIGPVPLGMSNFAGFIIVWILGSAIATLTFLLE 635
            ......|..:|   :|| ....|.:||.||...:.|.|..:|.|..|:|
Zfish   799 WWYDKGECGSGGGDSKD-KTSALSLSNVAGVFYILIGGLGLAMLVALVE 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir41a	NP_995744.4	None
gria1a	NP_991161.1	Periplasmic_Binding_Protein_Type_1	26..387	CDD:299141
		ANF_receptor	36..369	CDD:279440
		PBP2_iGluR_AMPA_GluR1	404..806	CDD:270447	77/459 (17%)
		Lig_chan	536..836	CDD:278489	62/333 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591483
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840