Protein Alignment Ir41a and grin2bb

DIOPT Version :10

• Sequence 1: NP_995744.4
• Gene: Ir41a / 2768714
• FlyBaseID: FBgn0040849
• Length: 648
• Species: Drosophila melanogaster
• Sequence 2: NP_001121809.1
• Gene: grin2bb / 559976
• ZFINID: ZDB-GENE-061207-27
• Length: 1770
• Species: Danio rerio
• Alignment Length: 721
• Identity: 140/721 - (19%)
• Similarity: 249/721 - (34%)
• Gaps: 198/721 - (27%)

  Fly    44 SFVGINIK-------SFDDNGGHYIIDTGLKKKELQNKHLFL----DE--LVIKIIISIEVT-HC 94
            ||||..::       |.||  |...|...:||  ||:..:.|    :|  .:.::..|:.:| :.
Zfish   267 SFVGWELEEVLLLDMSVDD--GDSKIQNQMKK--LQSPVILLYCTKEEATTIFEVAHSVGLTGYG 327

  Fly    95 ETFVV---FDKDIDRFVNAFNKASV---YSIWRSLHNKFVFAHIANESPESRNHFFEDQPNILFV 153
            .|::|   ...|.|...|.|....:   |..|.......|...:|..:..:.....:..|:.|..
Zfish   328 YTWIVPSLVAGDTDNVPNVFPTGLISVSYDEWDYGLEARVRDAVAIIAMATSTMMLDRGPHTLLK 392

  Fly   154 VRDHSSASSFDIKTNKFVGRKAENPSQMILVDRYLA-----------SEQRFQFGKSLFADKLN- 206
            ...|.:.   |.|     |.|:.||::::   |||.           ||..||....|....||
Zfish   393 SGCHGAP---DKK-----GSKSGNPNEVL---RYLMNVTFEGRNLSFSEDGFQMHPKLVIILLNK 446

  Fly   207 -----------------------------NLQGRE--------------VIIAGFDYPPYTVIKH 228
                                         :.:.||              ||:...|....|.:::
Zfish   447 ERQYERVGKWENGSLAMKYHVWPRFELYSDAEEREDDHLSIVTLEEAPFVIVEDVDPLSGTCMRN 511

  Fly   229 NMSTNAQ--DMGVSGESDFKNVYIDGTETRIVLNFC----------EQFNCTIQIDSSAANDWGK 281
            .:....|  ...::|:|   .:||    .|....||          .:|...:.:.::..:  ||
Zfish   512 TVPCRKQLKLQNLTGDS---GIYI----KRCCKGFCIDILKKIAKSVKFTYDLYLVTNGKH--GK 567

  Fly   282 VYPNMSGDGALGMLINRKADICIGAMYSWYEDYTYLDLSMYLVRSGITCLVPAPLRLTSWYLPLE 346
            .. |.:.:|.:|.::.:.|.:.:|::....|....:|.|:..:.:||:.:|.......|....||
Zfish   568 KI-NGTWNGMVGEVVLKNAHMAVGSLTINEERSEVIDFSVPFIETGISVMVSRSNGTVSPSAFLE 631

  Fly   347 PFKETLWAAILLCLCAEATGLVLAYKSEQALYVLP-GYREGWWTCTSFG-------------VCT 397
            ||...:|..:.:.|...:...|..::     |..| ||..    |.:.|             :..
Zfish   632 PFSADVWVMMFVMLLIVSAVAVFVFE-----YFSPVGYNR----CLADGREPGGPSFTIGKAIWL 687

  Fly   398 TFKLFISQS---GNSKAYSLTVRVLLFACFLNDLIITSIYGGGLASILTIPSMDEAADTVTRLRF 459
            .:.|..:.|   .|.|..:..:.|.::|.|.  :|..:.|...||:.:.   .:|..|.||.|..
Zfish   688 LWGLVFNNSVPVQNPKGTTSKIMVSVWAFFA--VIFLASYTANLAAFMI---QEEYVDQVTGLSD 747

  Fly   460 HRLQWAANSE---AWVSAIRASDEALVKDILYNFHIYSDDELLRLAQDQHMRIGFTVERLPFGHF 521
            .:.|...:..   .:.:....|.|..:::.....|.|       :.......:...:..|..|..
Zfish   748 KKFQHPNDFSPPFRFGTVPNGSTERNIRNNYKEMHSY-------MTSFHQKNVNEALHSLKSGKL 805

  Fly   522 -------AIGNYL-GPQAIDQLVIMKDDIYFQ---YTVAFVPRLWPLLDKLNTLIYSWHSSGFDK 575
                   |:.||: |.....:||.:.....|.   |.:|        :.|             |.
Zfish   806 DAFIYDAAVLNYMAGRDEGCKLVTIGSGYIFATTGYGIA--------IQK-------------DS 849

  Fly   576 YWEYRVVADNLNLKIQQQVQET----MTG-----TKDIGPVPLGMSNFAGFIIVWILGSAIA--T 629
            .|:..|....|.|....:::|.    :||     ..::....|.:.|.||  :.::||:|:|  .
Zfish   850 GWKRAVDLAILQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDVDNMAG--VFYMLGAAMALSL 912

  Fly   630 LTFLLE 635
            :||:.|
Zfish   913 ITFIAE 918

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir41a	NP_995744.4	None
grin2bb	NP_001121809.1	PBP1_iGluR_NMDA_NR2	107..465	CDD:380601	46/212 (22%)
		PBP2_iGluR_NMDA_Nr2	482..882	CDD:270436	81/451 (18%)
		NMDAR2_C	919..1770	CDD:463148	140/721 (19%)