DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir41a and grik4

DIOPT Version :9

Sequence 1:	NP_995744.4	Gene:	Ir41a / 2768714	FlyBaseID:	FBgn0040849	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	XP_021322087.1	Gene:	grik4 / 556582	ZFINID:	ZDB-GENE-070821-5	Length:	965	Species:	Danio rerio

Alignment Length:	768	Identity:	154/768 - (20%)
Similarity:	269/768 - (35%)	Gaps:	217/768 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 AIVG--KYLNESTICIFWNDK---FEFQLLHKSDYISFVGINIKSFDDNGGHYIIDTGLKKKELQ 72
            |:.|  .:.|.||.|:.....   ...::|.:...||...::::..||:..    .|.|.|:...
Zfish   149 AVAGLLTFFNSSTSCLICAQADCLLNLEVLLRQFLISKETLSVRMLDDSQD----PTPLLKEIRD 209

  Fly    73 NK-------------HLFLDELVIKIIISIEVTHCETFVVF-----DKDIDRFVN-----AFNKA 114
            :|             |:.|:......::|:..|:..|.:.|     |...|:.||     .||:.
Zfish   210 DKTATIIVDANATMSHVILERASELGMLSVYYTYILTSLEFSLLRLDDLADQRVNIVGFSVFNRT 274

  Fly   115 S------VYSIWRSLHNKFVFAHIANESPESRNHFFEDQPNILFVVRD-----HSSASSFDIKTN 168
            .      |.|:.||.......|..|. :|.|....|:....::..|::     :..|:....|::
Zfish   275 HPFFQDFVLSLNRSWQENCDHAPFAG-TPLSSALLFDAVHTVVAAVQELNRSQNVGATQLSCKSS 338

  Fly   169 KF--VGRKAENPSQMILVD------RYLASEQRFQFGKSLFADKLNNL---------QG------ 210
            |.  .|....|..:|:.::      .:.:..||..:...:..:..:.|         ||
Zfish   339 KIWEHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALRIMQNSRDGLRQIGQWHSEQGLSMERK 403

  Fly   211 ------------REVIIAGFDYPPYTVIKHNMSTNAQDMGVSGESDFKNVYIDG-TETRIVLNFC 262
                        ..:.|......||.:::    .|.|::  .|...::...:|. .|...:|.|
Zfish   404 LPSLNVTDTLFNTTLTITTILENPYVMLR----ANHQEL--EGNDRYEGFCVDMLKELADILKF- 461

  Fly   263 EQFNCTIQIDSSAANDWGKVY--PNMSG--DGALGMLINRKADICIGAMYSWYEDYTYLDLSMYL 323
             ::...:..|.        ||  |..:|  .|.:|.||:||||:.:.|:....|....:|.|...
Zfish   462 -KYRIRLVGDG--------VYGVPGANGTWTGMVGELISRKADLAVAALTITAEREKVIDFSKPF 517

  Fly   324 VRSGITCLVPAPL-RLTSWYLPLEPFKETLWAAILLCLCAEATGLVLAYKSEQALYVLPGYREGW 387
            :..||:.:....: |...::..|:||...:|..:||...|.:..|.|..:       |..|.  |
Zfish   518 MTLGISIMYRVHIGRRPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVAR-------LTPYE--W 573

  Fly   388 WT---CTSFGVCTTFKLFISQ--SGNS----------KAYSLTVRVLLFAC-----FLNDLIITS 432
            :.   |.. |.|:   |.|:|  .|||          :..::..|.|...|     :...|||.|
Zfish   574 YNPHPCLK-GRCS---LLINQYSLGNSFWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIIS 634

  Fly   433 IYGGGLASILT-------IPSMDEAAD-------------TVT-----RLRFHRLQWAANSEAWV 472
            .|...||:.||       |.|:|:.||             |:|     |.:.::..|........
Zfish   635 SYTANLAAFLTVQRMEVPIESVDDLADQTAIEYGTMHGGSTMTFFQNSRYQTYQRMWNFMYSKQP 699

  Fly   473 SAIRASDEALVKDILYNFHIYSDDELLRLAQDQHMR--------IGFTVERLPFGHFAIGNYLGP 529
            |....|.|..:..:|.:.:.|    ||....:::.|        ||..::...:|   ||..||.
Zfish   700 SVFVKSTEEGIARVLNSNYAY----LLESTMNEYYRQRNCNLTQIGGLLDTKGYG---IGMPLGS 757

  Fly   530 QAIDQ--LVIMKDDIYFQYTVAFVPRLWPLLDKLNTLIYSWHSSGFDKYWEYRVVADNLNLKIQQ 592
            ...|:  |.|::  :..:..:..:.|.|            |......|..::|...
Zfish   758 VYRDEFDLAILR--LQEENRLEILKRKW------------WDGGKCPKEEDHRAKG--------- 799

  Fly   593 QVQETMTGTKDIGPVPLGMSNFAGFIIVWILGSAIATLTFLLELSLTYILKQS 645
                            |||.|..|..:|.:.|..:|  .|:..|...::|:.:
Zfish   800 ----------------LGMENIGGIFVVLVCGLLVA--IFMAVLEFVWMLRHT 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir41a	NP_995744.4	None
grik4	XP_021322087.1	Periplasmic_Binding_Protein_Type_1	26..400	CDD:324556	48/255 (19%)
grik4	XP_021322087.1	PBP2_iGluR_kainate_KA1	425..785	CDD:270442	91/409 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590974
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840