DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir41a and grik2

DIOPT Version :9

Sequence 1:	NP_995744.4	Gene:	Ir41a / 2768714	FlyBaseID:	FBgn0040849	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	XP_021322472.1	Gene:	grik2 / 556013	ZFINID:	ZDB-GENE-080414-1	Length:	908	Species:	Danio rerio

Alignment Length:	517	Identity:	99/517 - (19%)
Similarity:	168/517 - (32%)	Gaps:	150/517 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 QFGKSLFADKLNNLQGREVIIAGFDYPPYTVIKHNMSTNAQDMGVSGESDFKNVYID-------- 251
            |.||:  |:..::|..|.::::.....||.:.|.:      |..:.|...|:...:|
Zfish   417 QKGKT--ANVTDSLSNRSLVVSTILEEPYVMFKKS------DKPLYGNDRFEGYCVDLLRELAAI 473

  Fly   252 ---GTETRIVLNFCEQFNCTIQIDSSAANDWGKVYPNMSGDGALGMLINRKADICIGAMYSWYED 313
               |.|.|:|    |......|.:||  ..|         :|.:..|::.|||:.:..:...|..
Zfish   474 LGFGYELRLV----EDGRYGAQDESS--GQW---------NGMVRELMDHKADLAVAPLAITYVR 523

  Fly   314 YTYLDLSMYLVRSGITCLVPAP----LRLTSWYLPLEPFKETLWAAILLCLCAEATGLVLAYKSE 374
            ...:|.|...:..||:.|...|    ..:.|:..||.|   .:|..||           |||...
Zfish   524 EKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSP---DIWMYIL-----------LAYLGV 574

  Fly   375 Q-ALYVLPGYREGWW----TC--------TSFGVCTTF----KLFISQSGNSKAYSLTVRVLLFA 422
            . .|:|:..:....|    .|        .:|.:..:|    ...:.|.......:|:.|::...
Zfish   575 SCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGI 639

  Fly   423 CFLNDLIITSIYGGGLASILTIPSMDEAADTV-------------------------TRLRFHRL 462
            .:...|||.|.|...||:.||:..|:...|:.                         |::..:..
Zfish   640 WWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGVVEDGSTMTFFKKTKISTYDK 704

  Fly   463 QWAANSEAWVSAIRASDEALVKDIL---YNFHIYSDD-ELLRLAQDQHMRIGFTVERLPFGHFAI 523
            .|...|....|.:..|.|..::.:|   |.|.:.|.. |.:........:||..::...:|   :
Zfish   705 MWEFMSSRRHSVMVKSIEEGIERVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKAYG---V 766

  Fly   524 GNYLGPQAIDQLVIMKDDIYFQYTVAFVPRLWPLLDKLNTLIYSWHSSG-----FDKYWEYRVVA 583
            |..:|.                          |..||:...|......|     .:|:|......
Zfish   767 GTPMGS--------------------------PYRDKITIAILQLQEEGKLHMMKEKWWRGNGCP 805

  Fly   584 DNLNLKIQQQVQETMTGTKDIGPVPLGMSNFAGFIIVWILGSAIATLTFLLELSLTYILKQS 645
            :..|.:..                .||:.|..|..||  |.:.:....|:......|..||:
Zfish   806 EEENKEAS----------------ALGVQNIGGIFIV--LAAGLVLSVFVAVGEFLYKSKQN 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir41a	NP_995744.4	None
grik2	XP_021322472.1	PBP1_iGluR_Kainate	37..414	CDD:380605
grik2	XP_021322472.1	Periplasmic_Binding_Protein_Type_2	430..800	CDD:419667	81/433 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591725
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840