DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir41a and grin2da

DIOPT Version :9

Sequence 1:	NP_995744.4	Gene:	Ir41a / 2768714	FlyBaseID:	FBgn0040849	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	XP_009292354.1	Gene:	grin2da / 449864	ZFINID:	ZDB-GENE-041008-124	Length:	1916	Species:	Danio rerio

Alignment Length:	416	Identity:	77/416 - (18%)
Similarity:	144/416 - (34%)	Gaps:	120/416 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   280 GKVYPNMSG--DGALGMLINRKADICIGAMYSWYEDYTYLDLSMYLVRSGITCLVPAPLRLTSWY 342
            |:...|:.|  :|.:|.:::::||:.||::....|....::.|:..|.:||:.:|.......|..
Zfish   532 GRHGKNIDGQWNGMVGEVVSKRADMAIGSLTINEERSEVVEFSVPFVETGISVMVSRSNGTVSPS 596

  Fly   343 LPLEPFKETLWAAI-LLCLCAEA-TGLVLAYKSEQALYVLPGYREGWWTCTSFG---------VC 396
            ..|||:...:|..: ::||...| |..:..:.|.      .||.....:..:.|         :.
Zfish   597 AFLEPYSPAVWVMMFVMCLSVVAVTVFIFEFFSP------VGYNRSLQSGKTAGGSKFTIGKSIW 655

  Fly   397 TTFKLFISQS---GNSKAYSLTVRVLLFACFLNDLIITSIYGGGLASILTIPSMDEAADTVTRLR 458
            ..:.|..:.|   .|.:..:..:.||::|.|.  :|..:.|...||:.:.   .:|..|||:.|.
Zfish   656 LLWALVFNNSVPVENPRGTTSKIMVLVWAFFA--VIFLASYTANLAAFMI---QEEYIDTVSGLS 715

  Fly   459 FHRLQWAANSE---AWVSAIRASDEALVKDILYNFHIYSDDELLRLAQDQHMRIGFTVERLPFGH 520
            ..:.|......   .:.:....|.|..::....|.|.|       :.::....:...:|.|..|.
Zfish   716 DKKFQHPTEQYPPLRFGTVPNGSTEENIRSNYPNMHQY-------MVRNNQRGVEDAIENLKTGK 773

  Fly   521 F-------AIGNYLG----------------------------------PQAIDQLVIMKDDIYF 544
            .       |:.||:.                                  |..:..|.::.||
Zfish   774 LDAFIYDAAVLNYMARKDEGCKVMTIGSGKVFATTGYGVALHKNSRWKRPLDLALLQLVGDD--- 835

  Fly   545 QYTVAFVPRLWPLLDKLNTLIYSWHSSGFDKYWEYRVVADNLNLKIQQQVQETMTGTKDIGPVPL 609
              .:..:.|||     |:.:.:                    |.||     |.|:...||
Zfish   836 --EIDMLERLW-----LSGICH--------------------NDKI-----EVMSSKLDI----- 863

  Fly   610 GMSNFAGFIIVWILGSAIATLTFLLE 635
              .|.||...:.::...::.|.|..|
Zfish   864 --DNMAGVFYMLLVAMGLSLLVFAWE 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir41a	NP_995744.4	None
grin2da	XP_009292354.1	PBP1_iGluR_NMDA_NR2	42..441	CDD:107373
		PBP2_iGluR_NMDA_Nr2	452..851	CDD:270436	64/366 (17%)
		HisJ	<507..>590	CDD:223904	15/57 (26%)
		Lig_chan	605..877	CDD:278489	55/331 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591657
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930