DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir41a and Grik

DIOPT Version :9

Sequence 1:	NP_995744.4	Gene:	Ir41a / 2768714	FlyBaseID:	FBgn0040849	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster

Alignment Length:	520	Identity:	108/520 - (20%)
Similarity:	185/520 - (35%)	Gaps:	145/520 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 ASEQRFQFGK-----SLFADKLNNLQGREVIIAGFDYPPYTVIKHNMSTNAQDMGVSGESDFKNV 248
            :.|..||..:     ||..| :.:|..:..::......||.::|.....      :.|...|:..
  Fly   386 SGEDGFQENRPAPAHSLEPD-MRSLVNKSFVVITAISEPYGMLKETSEK------LEGNDQFEGF 443

  Fly   249 YID-GTETRIVLNFCEQFNCTIQIDSSAANDWGKVYPNMSGD--GALGMLINRKADICIGAMYSW 310
            .|: ..|....|.|  .:...:|.|    |.:|.:.|. :|:  |.|..:|:.:||:.|..:...
  Fly   444 GIELIDELSKKLGF--SYTWRLQED----NKYGGIDPK-TGEWNGMLREIIDSRADMGITDLTMT 501

  Fly   311 YEDYTYLDLSMYLVRSGITCLVPAPL----RLTSWYLPLEPFKETLWAAILLCLCAEATGLVLAY 371
            .|..:.:|.::..:..||..|...|:    :|.|:   :.||...:|           ..|.|||
  Fly   502 SERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSF---MSPFSGEVW-----------LWLGLAY 552

  Fly   372 KSEQ-ALYVL----PGYREGWWTCT----------SFGVCTTFKL-FISQSGNS---KAYSLTVR 417
            .... :::||    |...:..:.|.          ||..|..|.: .:.|.|:.   ||||  .|
  Fly   553 MGVSISMFVLGRLSPAEWDNPYPCIEEPTELENQFSFANCLWFSIGALLQQGSELAPKAYS--TR 615

  Fly   418 VLLFACFLNDLIITSIYGGGLASILTIPSMDEAADTVTRLRFHRLQWAANSEAWVSAIRASDE-- 480
            .:..:.:...||:.|.|...||:.||:.|:                        |:.|..:|:
  Fly   616 AVAASWWFFTLILVSSYTANLAAFLTVESL------------------------VTPINDADDLS 656

  Fly   481 ---------ALVKDILYNFHIYSD----DELLRLAQDQHMRIGFT----VERLPFGHFAIGNYLG 528
                     |.:....:||...|:    ..:....:|....:..|    |:|:...::|.
  Fly   657 KNKGGVNYGAKIGGATFNFFKESNYPTYQRMYEFMRDNPQYMTNTNQEGVDRVENSNYAF----- 716

  Fly   529 PQAIDQLVIMKDDIYFQYTVAFVPRLWPLLDKLNTLIYSWHSSGFD----KYWEYRVVADNLNLK 589
                    :|:..     |:.::......|.::..|:   ...|:.    |.|.||.......|:
  Fly   717 --------LMEST-----TIEYITERRCTLTQVGALL---DEKGYGIAMRKNWPYRDTLSQAVLE 765

  Fly   590 IQQQVQETMTGTK----------------DIGPVPLGMSNFAGFIIVWILGSAIATLTFLLELSL 638
            :|:|...|...||                |.|.|.|.:||..|..:|..:||.......|||:.|
  Fly   766 MQEQGLLTKMKTKWWQEKRGGGACSDADEDSGAVALEISNLGGVFLVMGVGSFFGIFVSLLEMVL 830

Fly 639 638
Fly 831 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir41a	NP_995744.4	None
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	1/4 (25%)
		ANF_receptor	53..374	CDD:279440
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	87/443 (20%)
		Lig_chan	543..816	CDD:278489	64/330 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462836
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840