Protein Alignment Ir41a and gria4a

DIOPT Version :10

• Sequence 1: NP_995744.4
• Gene: Ir41a / 2768714
• FlyBaseID: FBgn0040849
• Length: 648
• Species: Drosophila melanogaster
• Sequence 2: NP_999971.1
• Gene: gria4a / 407735
• ZFINID: ZDB-GENE-020125-7
• Length: 898
• Species: Danio rerio
• Alignment Length: 774
• Identity: 150/774 - (19%)
• Similarity: 253/774 - (32%)
• Gaps: 230/774 - (29%)

  Fly    10 VLSAIVGKY----LNESTICI-FWNDKFEFQLLHKSDYISFVGINIKSFDDNGGHYIIDTGLKKK 69
            ||.||:.|.    ...|.||: .:||....:||...|            ......::||  |:.:
Zfish   161 VLQAIMEKAGQNGWQVSAICVENFNDASYRRLLEDLD------------RRQEKKFVID--LEAE 211

  Fly    70 ELQNKHLFLDELVIKIIISIEVTHCETFVVFD---KDI--DRFVNA-----------FNKASVYS 118
            .|||    :.|.::.:...::..|   ::|.:   |||  :||::.           |:|..|..
Zfish   212 RLQN----ILEQIVSVGKHVKGYH---YIVANLGFKDISLERFMHGGANVTGFQLVDFSKPMVIK 269

  Fly   119 I---WRSLHNKFVFAHIANES-PESRNHFFEDQPNILFVVRDHSSASSFDIKTNKFVGRKAENP- 178
            :   |..|..:   .:..:|| |...:....|...::.....:......||......|....||
Zfish   270 LMQRWNKLDQR---EYPGSESPPRYTSSLTYDGVLVMAEAFRNLRRQKIDISRRGNAGDCLANPA 331

  Fly   179 ---SQMILVDRYLAS---------------EQRFQFGKSLFADKLNN------------------ 207
               :|.|.::|.|..               .:|..:...:|..|.|.
Zfish   332 APWNQGIDMERTLKQVRIQGLTGNIQFDHYGRRVNYTMDVFELKSNGPRKIGYWNDLDKLVLVQN 396

  Fly   208 ---------LQGREVIIAGFDYPPYTVIKHNMSTNAQDMGVSGESDFKNVYIDGTETRIVLNFCE 263
                     ::.|.||:......||.::|.|...      ..|...|:...:| ..:.:..:...
Zfish   397 ELSMGNDSAMENRTVIVTTIMEGPYVMLKKNWEM------YEGNEQFEGYCVD-LASEVAKHIGI 454

  Fly   264 QFNCTIQIDS--SAANDWGKVYPNMSGDGALGMLINRKADICIGAMYSWYEDYTYLDLSMYLVRS 326
            ::..:|.:|.  .|.:...|::     :|.:|.|:..||:|.:..:.........:|.|...:..
Zfish   455 KYKISIVLDGKYGARDPETKIW-----NGMVGELVYGKAEIAVAPLAITLVREEVIDFSKPFMSL 514

  Fly   327 GITCLVPAPLRLTSWYLP-LEPFKETLWAAILLCLCAEATGLVLAYKSEQALYVLPGYREGWWT- 389
            ||:.::..|.:....... |:|....:|..|:....  ...:||...|..:.|       .|.|
Zfish   515 GISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYI--GVSVVLFLVSRFSPY-------EWHTE 570

  Fly   390 --------------CTSFGVCTT--FKL--FISQSGNSKAYSLTVRVLLFACFLNDLIITSIYGG 436
                          ...||:..:  |.|  |:.|..:....||:.|::....:...|||.|.|..
Zfish   571 EPEEGSDGPPSDQPPNEFGIFNSLWFSLGAFMQQGCDFTPRSLSGRIVGGVWWFFTLIIISSYTA 635

  Fly   437 GLASILTIPSM----DEAADTV--------------TRLRFHRLQWAANSEAW------------ 471
            .||:.||:..|    :.|.|..              |:..|.|.:.|...:.|
Zfish   636 NLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPTVFT 700

  Fly   472 ------VSAIRASDEALVKDILYNFHIYSDDELLRLAQDQHMRIGFTVERLPFGHFAIGNYLGPQ 530
                  |:.:|.|...      |.|       ||....::     :|.:|.|.....:|..|..:
Zfish   701 KTTAEGVARVRKSKGK------YAF-------LLESTMNE-----YTEQRKPCDTMKVGGNLDSK 747

  Fly   531 AIDQLVIMKDDIYFQYTVAFVPRLWPLLDKLNTLIYSWHSSGFDKYWEYRVVADNLNLKIQQQVQ 595
            .              |.|| .|:...|...:|..:.....:|         |.|.|..|......
Zfish   748 G--------------YGVA-TPKGSQLGTPVNLAVLKLSEAG---------VLDKLKNKWWYDKG 788

  Fly   596 E---TMTGTKDIGPVPLGMSNFAGFIIVWILGSAIATLTFLLE-----------LSLTY 640
            |   ..:|:||.....|.:||.||...:.:.|..:|.|..|:|           |.||:
Zfish   789 ECGPKDSGSKDKSSQALSLSNVAGVFYILVGGLGLAMLVALVEFCYKSRAEAKKLKLTF 847

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir41a	NP_995744.4	None
gria4a	NP_999971.1	PBP1_iGluR_AMPA_GluR4	23..395	CDD:380611	49/257 (19%)
		PBP2_iGluR_AMPA_GluR4	408..790	CDD:270445	84/444 (19%)