DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir41a and gria4a

DIOPT Version :9

Sequence 1:	NP_995744.4	Gene:	Ir41a / 2768714	FlyBaseID:	FBgn0040849	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_999971.1	Gene:	gria4a / 407735	ZFINID:	ZDB-GENE-020125-7	Length:	898	Species:	Danio rerio

Alignment Length:	774	Identity:	150/774 - (19%)
Similarity:	253/774 - (32%)	Gaps:	230/774 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VLSAIVGKY----LNESTICI-FWNDKFEFQLLHKSDYISFVGINIKSFDDNGGHYIIDTGLKKK 69
            ||.||:.|.    ...|.||: .:||....:||...|            ......::||  |:.:
Zfish   161 VLQAIMEKAGQNGWQVSAICVENFNDASYRRLLEDLD------------RRQEKKFVID--LEAE 211

  Fly    70 ELQNKHLFLDELVIKIIISIEVTHCETFVVFD---KDI--DRFVNA-----------FNKASVYS 118
            .|||    :.|.::.:...::..|   ::|.:   |||  :||::.           |:|..|..
Zfish   212 RLQN----ILEQIVSVGKHVKGYH---YIVANLGFKDISLERFMHGGANVTGFQLVDFSKPMVIK 269

  Fly   119 I---WRSLHNKFVFAHIANES-PESRNHFFEDQPNILFVVRDHSSASSFDIKTNKFVGRKAENP- 178
            :   |..|..:   .:..:|| |...:....|...::.....:......||......|....||
Zfish   270 LMQRWNKLDQR---EYPGSESPPRYTSSLTYDGVLVMAEAFRNLRRQKIDISRRGNAGDCLANPA 331

  Fly   179 ---SQMILVDRYLAS---------------EQRFQFGKSLFADKLNN------------------ 207
               :|.|.::|.|..               .:|..:...:|..|.|.
Zfish   332 APWNQGIDMERTLKQVRIQGLTGNIQFDHYGRRVNYTMDVFELKSNGPRKIGYWNDLDKLVLVQN 396

  Fly   208 ---------LQGREVIIAGFDYPPYTVIKHNMSTNAQDMGVSGESDFKNVYIDGTETRIVLNFCE 263
                     ::.|.||:......||.::|.|...      ..|...|:...:| ..:.:..:...
Zfish   397 ELSMGNDSAMENRTVIVTTIMEGPYVMLKKNWEM------YEGNEQFEGYCVD-LASEVAKHIGI 454

  Fly   264 QFNCTIQIDS--SAANDWGKVYPNMSGDGALGMLINRKADICIGAMYSWYEDYTYLDLSMYLVRS 326
            ::..:|.:|.  .|.:...|::     :|.:|.|:..||:|.:..:.........:|.|...:..
Zfish   455 KYKISIVLDGKYGARDPETKIW-----NGMVGELVYGKAEIAVAPLAITLVREEVIDFSKPFMSL 514

  Fly   327 GITCLVPAPLRLTSWYLP-LEPFKETLWAAILLCLCAEATGLVLAYKSEQALYVLPGYREGWWT- 389
            ||:.::..|.:....... |:|....:|..|:....  ...:||...|..:.|       .|.|
Zfish   515 GISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYI--GVSVVLFLVSRFSPY-------EWHTE 570

  Fly   390 --------------CTSFGVCTT--FKL--FISQSGNSKAYSLTVRVLLFACFLNDLIITSIYGG 436
                          ...||:..:  |.|  |:.|..:....||:.|::....:...|||.|.|..
Zfish   571 EPEEGSDGPPSDQPPNEFGIFNSLWFSLGAFMQQGCDFTPRSLSGRIVGGVWWFFTLIIISSYTA 635

  Fly   437 GLASILTIPSM----DEAADTV--------------TRLRFHRLQWAANSEAW------------ 471
            .||:.||:..|    :.|.|..              |:..|.|.:.|...:.|
Zfish   636 NLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPTVFT 700

  Fly   472 ------VSAIRASDEALVKDILYNFHIYSDDELLRLAQDQHMRIGFTVERLPFGHFAIGNYLGPQ 530
                  |:.:|.|...      |.|       ||....::     :|.:|.|.....:|..|..:
Zfish   701 KTTAEGVARVRKSKGK------YAF-------LLESTMNE-----YTEQRKPCDTMKVGGNLDSK 747

  Fly   531 AIDQLVIMKDDIYFQYTVAFVPRLWPLLDKLNTLIYSWHSSGFDKYWEYRVVADNLNLKIQQQVQ 595
            .              |.|| .|:...|...:|..:.....:|         |.|.|..|......
Zfish   748 G--------------YGVA-TPKGSQLGTPVNLAVLKLSEAG---------VLDKLKNKWWYDKG 788

  Fly   596 E---TMTGTKDIGPVPLGMSNFAGFIIVWILGSAIATLTFLLE-----------LSLTY 640
            |   ..:|:||.....|.:||.||...:.:.|..:|.|..|:|           |.||:
Zfish   789 ECGPKDSGSKDKSSQALSLSNVAGVFYILVGGLGLAMLVALVEFCYKSRAEAKKLKLTF 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir41a	NP_995744.4	None
gria4a	NP_999971.1	PBP1_iGluR_AMPA_GluR4	23..393	CDD:107383	49/255 (19%)
		ANF_receptor	34..375	CDD:279440	47/237 (20%)
		PBP2_iGluR_AMPA_GluR4	408..790	CDD:270445	84/444 (19%)
		Lig_chan	540..821	CDD:278489	66/331 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591672
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840