DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir41a and Nmdar1

DIOPT Version :9

Sequence 1:	NP_995744.4	Gene:	Ir41a / 2768714	FlyBaseID:	FBgn0040849	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster

Alignment Length:	705	Identity:	142/705 - (20%)
Similarity:	238/705 - (33%)	Gaps:	223/705 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 VGINIKSFDDNGGH-----YIIDTGLKKKELQNKHLFLDELVIKIIISIEVTHCETFVVFDKDI- 104
            :|:.::....:.||     |::.:.:|                      |:...||.....||.
  Fly   283 LGLQLEHAHSDKGHIRDSVYVLASAIK----------------------EMISNETIAEAPKDCG 325

  Fly   105 DRFVNAFNKASVYSIWRSLHNKFVFAHIANESPESRNHFFEDQPNILFV------VRDHSSAS-- 161
            |..||          |.|....|.:....|.:.|:....|:|..:.::.      :|:.....
  Fly   326 DSAVN----------WESGKRLFQYLKSRNITGETGQVAFDDNGDRIYAGYDVINIREQQKKHVV 380

  Fly   162 ---SFD---------IKTNKFV--GRKAENPSQMILVDRYL----ASEQRFQFGKSLFADKLNNL 208
               |:|         |..::.:  |::...| :.|::..:|    ..|:.|.:.:.:..|:..
  Fly   381 GKFSYDSMRAKMRMRINDSEIIWPGKQRRKP-EGIMIPTHLRLLTIEEKPFVYVRRMGDDEFR-- 442

  Fly   209 QGREVIIAGFDYPPYTVIKHNMSTNAQDMGVSGESDFKNVYIDGTETRIVLNFCEQFNCTIQIDS 273
                   ...|..|..:..::.:|       :.|...:...||     :::...::.|.|..:..
  Fly   443 -------CEPDERPCPLFNNSDAT-------ANEFCCRGYCID-----LLIELSKRINFTYDLAL 488

  Fly   274 SAANDWGK-VYPNMSG--------DGALGMLINRKADICIGAMYSWYEDYTYLDLSMYLVRSGIT 329
            |....:|. :..|.:|        .|.:|.|:|.:||:.:..:....|...|::.|......|||
  Fly   489 SPDGQFGHYILRNNTGAMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGIT 553

  Fly   330 CLVPAPLRLTSWYLPLEPFKETLWAAILLCLCAEATGLVLAYKSEQALYVLPGYREGWWTCTSFG 394
            .|...|.|.::....|:||..|||  ||:.:......||        ||:|..:       :.||
  Fly   554 ILEKKPSRSSTLVSFLQPFSNTLW--ILVMVSVHVVALV--------LYLLDRF-------SPFG 601

  Fly   395 VCTTFKLFISQSGNSKAYSLTVRV-LLFACFLND-----------------------LIITSIYG 435
               .|||..|.|...||.:|:..| ..:...||.                       :||.:.|.
  Fly   602 ---RFKLSHSDSNEEKALNLSSAVWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYT 663

  Fly   436 GGLASILTI--PSMDEAADTVTRLR-------------------FHRLQWAANSEAWVSAIR-AS 478
            ..||:.|.:  |....:.....|||                   |.|....:|....:.|.. |:
  Fly   664 ANLAAFLVLERPKTKLSGINDARLRNTMENLTCATVKGSSVDMYFRRQVELSNMYRTMEANNYAT 728

  Fly   479 DEALVKDI----LYNFHIYSDDEL-LRLAQDQHMRIGFTVERLPFGH--FAIGNYLGPQAIDQLV 536
            .|..::|:    |..| |:....| ...::|..:   .|...| ||.  :.||...|.
  Fly   729 AEQAIQDVKKGKLMAF-IWDSSRLEYEASKDCEL---VTAGEL-FGRSGYGIGLQKGS------- 781

  Fly   537 IMKDDIYFQYTVAFVPRLWPLLDKLNTLIYSWHSSGF----DKYWEYR-VVADNLNLKIQQQVQE 596
                               |..|.:...|..:|.|||    ||.|.:. .|..|..|     .::
  Fly   782 -------------------PWTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQNCEL-----FEK 822

  Fly   597 TMTGTKDIGPVPLGMSNFAGFIIVWILGSAIATLTFLLELSLTY----ILKQSNL 647
            |        |..||:.|.||..|  ::|..||....|:.:.:.|    :.||..|
  Fly   823 T--------PNTLGLKNMAGVFI--LVGVGIAGGVGLIIIEVIYKKHQVKKQKRL 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir41a	NP_995744.4	None
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	24/153 (16%)
		ANF_receptor	58..371	CDD:279440	20/119 (17%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	98/472 (21%)
		HisJ	451..>558	CDD:223904	23/118 (19%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	40/154 (26%)
		Lig_chan	575..838	CDD:278489	73/328 (22%)
		CaM_bdg_C0	854..882	CDD:287524	4/14 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463039
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840