DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir41a and GluRIA

DIOPT Version :9

Sequence 1:	NP_995744.4	Gene:	Ir41a / 2768714	FlyBaseID:	FBgn0040849	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster

Alignment Length:	729	Identity:	144/729 - (19%)
Similarity:	245/729 - (33%)	Gaps:	216/729 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 SDYISFVGINIKSFD--DNGGHYIIDTGLKKKEL------QNKHLFLDELVIKIIISIEVTHCET 96
            ||.:.|..|||..|.  |:....:.|....:|.|      |:::......:..|.....:.:...
  Fly   272 SDVVEFGAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAV 336

  Fly    97 FVVFDKDIDRFVNAFNKASVYSIWRSLHNKFVFAHIANESPESRNHFFEDQPNILFVVRDHSSAS 161
            ||:        |.|||:     |.|...::|...|:     :.|:|......:   ....:.|::
  Fly   337 FVL--------VEAFNR-----ILRKKPDQFRSNHL-----QRRSHGGSSSSS---ATGTNESSA 380

  Fly   162 SFDIKTNK-FV-----GRKAENPSQMILVDRYLASEQRFQFGKSLFADKLNNLQGREVIIAGFDY 220
            ..|..|:| :|     |.|.....:.:.:|. |:.|.||            :..||.:
  Fly   381 LLDCNTSKGWVTPWEQGEKISRVLRKVEIDG-LSGEIRF------------DEDGRRI------- 425

  Fly   221 PPYTVIKHNMSTNA---------QDMGV------------------SGESDFKNVYIDGT---ET 255
             .||:....||.|:         .|.|:                  :|:.|..:.||..:   |.
  Fly   426 -NYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEEP 489

  Fly   256 RIVL----------------NFCE--------QFNCTIQIDSSAANDWG--KVYPNMSGDGALGM 294
            .:.|                .:|:        |.....:|......::|  ..|.....||.:|.
  Fly   490 YLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGE 554

  Fly   295 LINRKADICIGAMYSWYEDYTYLDLSMYLVRSGITCLVPAPLRLTSWYLP-LEPFKETLWAAILL 358
            ||.::|||.|.||....|....:|.|...:..||:.::..|::.|..... |.|..:.:|.:::|
  Fly   555 LIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVIL 619

  Fly   359 CLC------------------------AEAT-----GLV-LAYKSEQALYVLPGYREGWWTCTSF 393
            ...                        |::|     |:: .|..||...:|.|.....:....||
  Fly   620 SYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSF 684

  Fly   394 GVCTTFKLFISQSGNSKAYSLTVRVLLFACFLNDLIITSIYGGGLASILTIPSMDEAADTVTRLR 458
            ..  :...|:.|..:....|:..|:.....:...:|:.|.|...||:.||:..|.....|...|.
  Fly   685 WY--SLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLT 747

  Fly   459 ------------------FHRLQWAANSEAWVSAIRASDEALVKDILYNFHIYSDDELLRLAQDQ 505
                              |.|.|...:::.|        |.:..:..::.|.|  ||.:|..:..
  Fly   748 MQTDVNYGTLLYGSTWEFFRRSQIGLHNKMW--------EYMNANQHHSVHTY--DEGIRRVRQS 802

  Fly   506 HMRIGFTVE---------RLPFGHFAIGNYLGPQAIDQLVIMKDDIYFQYTVAFVPRLWPLLDKL 561
            ..:....||         |.|.....:|..:..:.              :.|| .|...||..:|
  Fly   803 KGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKG--------------FGVA-TPIGSPLRKRL 852

  Fly   562 NTLIYSWHSSG-----FDKYWEYRVVADNLNLKIQQQVQETMTGTKDIGPVPLGMSNFAGFIIVW 621
            |..:.:...:|     .:|:| :.....||:       |||.|      |..|.:||.||...:.
  Fly   853 NEAVLTLKENGELLRIRNKWW-FDKTECNLD-------QETST------PNELSLSNVAGIYYIL 903

  Fly   622 ILGSAIATLTFLLE 635
            |.|..:|.:..::|
  Fly   904 IGGLLLAVIVAIME 917

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir41a	NP_995744.4	None
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	46/222 (21%)
		ANF_receptor	53..434	CDD:279440	41/203 (20%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	80/429 (19%)
		Lig_chan	612..907	CDD:278489	64/335 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462553
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840