DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir41a and gria3b

DIOPT Version :9

Sequence 1:	NP_995744.4	Gene:	Ir41a / 2768714	FlyBaseID:	FBgn0040849	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_938174.1	Gene:	gria3b / 368416	ZFINID:	ZDB-GENE-030616-53	Length:	883	Species:	Danio rerio

Alignment Length:	701	Identity:	129/701 - (18%)
Similarity:	235/701 - (33%)	Gaps:	214/701 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 DDNGGHYIIDTGLKKKELQNKHLFLDELVI--KIIISIEVTHCETFVVFDKDIDRFVNAFNKASV 116
            :..|.||||      ..|...::.||::.:  ..|...::.:.|..||     .:|:..
Zfish   229 NSRGYHYII------ANLGFTNISLDKVFLGGANISGFQIINPENLVV-----QQFLQR------ 276

  Fly   117 YSIWRSLHNKFVFAHIANESPESRNHFFEDQPNILFVVRDHSSASSF------------------ 163
               |..|..:        |.||::|           ....::||.|:
Zfish   277 ---WDRLDER--------EFPEAKN-----------TPLKYTSALSYDAILVIAEAFRYLRRQRV 319

  Fly   164 DIKTNKFVGRKAENP----SQMILVDRYLASEQ--------RF-QFGK----------------- 198
            |:......|....||    ||.|.::|.|...|        :| .||:
Zfish   320 DVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDSFGRRTNYTIDVYEMKTGGPR 384

  Fly   199 ----------------SLFADKLNNLQGREVIIAGFDYPPYTVIKHNMSTNAQDMGVSGESDFKN 247
                            ..|.:..::::.|.:::......||.:.|.|      .|.:.|...::.
Zfish   385 KIGYWNEFERFVNIMDQQFTNDSSSVENRTIVVTTIMEAPYVMYKKN------HMHLEGNEKYEG 443

  Fly   248 VYIDGTETRIVLNFCEQFNCTIQIDSSAANDWGKVYP-NMSGDGALGMLINRKADICIGAMYSWY 311
            ..:| ..:.|..:...::..:|.:|..    :|...| ..|.:|.:|.|:..:|||.:..:....
Zfish   444 YCVD-LASEIAKHVGIKYRLSIVMDGK----YGARDPETKSWNGMVGELVYGRADIAVAPLTITL 503

  Fly   312 EDYTYLDLSMYLVRSGITCLVPAPLRLTSWYLP-LEPFKETLWAAILLCLCAEATGLVLAYKS-E 374
            .....:|.|...:..||:.::..|.:....... |:|....:|      :|     :|.||.. .
Zfish   504 VREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW------MC-----IVFAYIGVS 557

  Fly   375 QALYVLPGYREGWWTC----------------TSFGVCTT--FKL--FISQSGNSKAYSLTVRVL 419
            ..|:::..:....|..                ..||:..:  |.|  |:.|..:....||:.|::
Zfish   558 VVLFLVSRFSPYEWQLDETDEVKDPQTPPDPPNDFGIFNSLWFSLGAFMQQGCDISPRSLSGRIV 622

  Fly   420 LFACFLNDLIITSIYGGGLASILTIPSM----DEAADTV--------------TRLRFHRLQWAA 466
            ....:...|||.|.|...||:.||:..|    :.|.|..              |:..|.|.:.|.
Zfish   623 GGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAV 687

  Fly   467 NSEAWVSAIRASDEALVKDILYNFHIYSDDELLRLAQDQHMRIGFTVE---------RLPFGHFA 522
            ..:.| |.:::::.::       |...:.|.:.|:.:.:. :..|.:|         |.|.....
Zfish   688 YEKMW-SYMKSAEPSV-------FAKTTPDGVARVRKSKG-KFAFLLESTMNEYIEQRKPCDTMK 743

  Fly   523 IGNYLGPQAIDQLVIMKDDIYFQYTVAFVPRLWPLLDKLNTLIYSWHSSGFDKYWEYRVVADNLN 587
            :|..|..:.              |.|| .|:...|.:.:|..:...:..|         :.|.|.
Zfish   744 VGGNLDSKG--------------YGVA-TPKGSALRNAVNLAVLKLNEQG---------LLDKLK 784

  Fly   588 LKIQQQVQETMTG---TKDIGPVPLGMSNFAGFIIVWILGSAIATLTFLLE 635
            .|......|..:|   :|| ....|.:||.||...:.:.|..:|.:..|:|
Zfish   785 NKWWYDKGECGSGGGDSKD-KTSALSLSNVAGVFYILVGGLGLAMMVALIE 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir41a	NP_995744.4	None
gria3b	NP_938174.1	Periplasmic_Binding_Protein_Type_1	25..396	CDD:299141	35/205 (17%)
		ANF_receptor	36..379	CDD:279440	35/188 (19%)
		PBP2_iGluR_AMPA	412..794	CDD:270433	80/436 (18%)
		Lig_chan	544..824	CDD:278489	62/324 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591769
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840