DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir41a and gria4b

DIOPT Version :9

Sequence 1:	NP_995744.4	Gene:	Ir41a / 2768714	FlyBaseID:	FBgn0040849	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_997917.2	Gene:	gria4b / 336069	ZFINID:	ZDB-GENE-030131-8013	Length:	904	Species:	Danio rerio

Alignment Length:	790	Identity:	147/790 - (18%)
Similarity:	244/790 - (30%)	Gaps:	282/790 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VLSAIVGKY----LNESTICI-FWNDKFEFQLLHKSD---------------------YISFVGI 48
            :|.||:.|.    ...|.||: .:||....|||...|                     .|..||.
Zfish   166 ILQAIMEKAGQNGWQVSAICVENFNDASYRQLLEDLDRRQEKTFVIDLEAERLNNMLEQIVSVGK 230

  Fly    49 NIKSFDDNGGHYII-DTGLKKKELQNKHLFLDELVIKIIISIEVTHCETFVVFDKDIDRFVNA-- 110
            ::|     |.|||: :.|.|                                 |.:::||::.
Zfish   231 HVK-----GYHYIMANLGFK---------------------------------DINLERFMHGGA 257

  Fly   111 ---------FNKASVYSI---WRSLHNKFVFAHIANESPESRNHFFEDQPNILFVVRDHSSASSF 163
                     |:...|..:   |..|..:        |.|.|      |.|      ..::||.::
Zfish   258 NVTGFQLVDFSNPMVIKLMQRWNKLDQR--------EYPGS------DAP------PKYTSALTY 302

  Fly   164 ------------------DIKTNKFVGRKAENP----SQMILVDRYLAS---------------E 191
                              ||......|....||    :|.|.::|.|..               .
Zfish   303 DGVMVMAEAFRNLRRQKVDISRRGIAGDCLANPAAPWNQGIDMERTLKQVHLQGLTGNVQFDHYG 367

  Fly   192 QRFQFGKSLF---------------ADKL-------------NNLQGREVIIAGFDYPPYTVIKH 228
            :|..:...:|               ||||             :.::.|.||:......||.::|.
Zfish   368 RRVNYTMDVFELKSNGPRRIGYWNDADKLVLTQDHALLPNETSGMENRTVIVTTIMEGPYVMLKK 432

  Fly   229 NMSTNAQDMGVSGESDFKNVYIDGTETRIVLNFCEQFNCTIQIDS--SAANDWGKVYPNMSGDGA 291
            |...      ..|...::...:| ..:.|..:...::..:|..|.  .|.:...|::     :|.
Zfish   433 NWEM------YEGNEQYEGYCVD-LASEIAKHIGFKYKISIVPDGKYGARDPETKIW-----NGM 485

  Fly   292 LGMLINRKADICIGAMYSWYEDYTYLDLSMYLVRSGITCLVPAPLRLTSWYLP-LEPFKETLWAA 355
            :|.|:..||:|.:..:.........:|.|...:..||:.::..|.:....... |:|....:|..
Zfish   486 VGELVYGKAEIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMC 550

  Fly   356 ILLCLCAEATGLVLAYK----------SEQALYVLPGYREGWWTCTSFGVCTT--FKL--FISQS 406
            |:......:..|.|..:          .|:....||..:..    ..||:..:  |.|  |:.|.
Zfish   551 IVFAYIGVSVVLFLVSRFSPYEWHTEEPEEGTDGLPSDQPP----NEFGIFNSLWFSLGAFMQQG 611

  Fly   407 GNSKAYSLTVRVLLFACFLNDLIITSIYGGGLASILTIPSM--------------DEAADTV--- 454
            .:....||:.|::....:...|||.|.|...||:.||:..|              |.|..|:
Zfish   612 CDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTDIAYGTLDSG 676

  Fly   455 -TRLRFHRLQWAANSEAW------------------VSAIRASDEALVKDILYNFHIYSDDELLR 500
             |:..|.|.:.|...:.|                  |:.:|.|...      |.|       ||.
Zfish   677 STKEFFRRSKIAVYEKMWSYMKSAEPTVFTKTTAEGVARVRKSKGK------YAF-------LLE 728

  Fly   501 LAQDQHMRIGFTVERLPFGHFAIGNYLGPQAIDQLVIMKDDIYFQYTVAFVPRLWPLLDKLNTLI 565
            ...::     :|.:|.|.....:|..|..:.              |.|| .|:...|...:|..:
Zfish   729 STMNE-----YTEQRKPCDTMKVGGNLDSKG--------------YGVA-TPKGSQLRSAVNLAV 773

  Fly   566 YSWHSSGF-----DKYWEYRVVADNLNLKIQQQVQETMTGTKDIGPVPLGMSNFAGFIIVWILGS 625
            ...:..|.     :|:|..:           .:......|.||.....|.:||.||...:.:.|.
Zfish   774 LKLNEQGLLDKLKNKWWYDK-----------GECGSGGGGEKDKSSQALSLSNVAGVFYILVGGL 827

  Fly   626 AIATLTFLLE 635
            .:|.|..|:|
Zfish   828 GLAMLVALIE 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir41a	NP_995744.4	None
gria4b	NP_997917.2	Periplasmic_Binding_Protein_Type_1	28..398	CDD:324556	52/289 (18%)
		PBP2_iGluR_AMPA_GluR4	414..793	CDD:270445	82/427 (19%)
		Lig_chan	546..827	CDD:306551	63/328 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591671
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840