DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir41a and Gria4

DIOPT Version :9

Sequence 1:	NP_995744.4	Gene:	Ir41a / 2768714	FlyBaseID:	FBgn0040849	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_001106655.1	Gene:	Gria4 / 29629	RGDID:	61863	Length:	902	Species:	Rattus norvegicus

Alignment Length:	787	Identity:	150/787 - (19%)
Similarity:	254/787 - (32%)	Gaps:	278/787 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VLSAIVGKY----LNESTICI-FWNDKFEFQLLHKSD---------------------YISFVGI 48
            :|.||:.|.    .:.|.||: .:||....|||.:.|                     .|..||.
  Rat   166 ILQAIMEKAGQNGWHVSAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGK 230

  Fly    49 NIKSFDDNGGHYII-DTGLKKKELQNKHLFLDELVIKIIISIEVTHCETFVVFDKDIDRFVNA-- 110
            ::|     |.|||| :.|.|                                 |..::||::.
  Rat   231 HVK-----GYHYIIANLGFK---------------------------------DISLERFIHGGA 257

  Fly   111 ---------FNKASVYSI---WRSLHNKFVFAHIANESPESRNHFFEDQPNILFVVRDHSSASSF 163
                     ||...|..:   |:.|..:        |.|.|     |..|.       ::||.::
  Rat   258 NVTGFQLVDFNTPMVTKLMDRWKKLDQR--------EYPGS-----ETPPK-------YTSALTY 302

  Fly   164 D-----------IKTNKF-VGRKAE------NPS----QMILVDRYLAS---------------E 191
            |           ::..|. :.|:..      ||:    |.|.::|.|..               .
  Rat   303 DGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHYG 367

  Fly   192 QRFQFGKSLF---------------ADKL----------NN---LQGREVIIAGFDYPPYTVIKH 228
            :|..:...:|               .|||          |:   ::.|.|::......||.:.|.
  Rat   368 RRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDMPTLGNDTAAIENRTVVVTTIMESPYVMYKK 432

  Fly   229 NMSTNAQDMGVSGESDFKNVYIDGTETRIVLNFCEQFNCTIQIDSS-AAND-----WGKVYPNMS 287
            |     .:| ..|...::...:| ..:.|..:...::...|..|.. .|.|     |
  Rat   433 N-----HEM-FEGNDKYEGYCVD-LASEIAKHIGIKYKIAIVPDGKYGARDADTKIW-------- 482

  Fly   288 GDGALGMLINRKADICIGAMYSWYEDYTYLDLSMYLVRSGITCLVPAPLRLTSWYLP-LEPFKET 351
             :|.:|.|:..||:|.|..:.........:|.|...:..||:.::..|.:....... |:|....
  Rat   483 -NGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYE 546

  Fly   352 LWAAILLCLCAEATGLVLAYKSEQALYVLPGYREGWWT--------------CTSFGVCTT--FK 400
            :|..|:....  ...:||...|..:.|       .|.|              ...||:..:  |.
  Rat   547 IWMCIVFAYI--GVSVVLFLVSRFSPY-------EWHTEEPEDGKEGPSDQPPNEFGIFNSLWFS 602

  Fly   401 L--FISQSGNSKAYSLTVRVLLFACFLNDLIITSIYGGGLASILTIPSM----DEAADTV----- 454
            |  |:.|..:....||:.|::....:...|||.|.|...||:.||:..|    :.|.|..
  Rat   603 LGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEI 667

  Fly   455 ---------TRLRFHRLQWAANSEAWVSAIRASDEALVKDILYNFHIYSDDELLRLAQDQHMRIG 510
                     |:..|.|.:.|...:.| :.:|:::.::       |...:.:.:.|:.:.:. :..
  Rat   668 AYGTLDSGSTKEFFRRSKIAVYEKMW-TYMRSAEPSV-------FTRTTAEGVARVRKSKG-KFA 723

  Fly   511 FTVE---------RLPFGHFAIGNYLGPQAIDQLVIMKDDIYFQYTVAFVPRLWPLLDKLNTLIY 566
            |.:|         |.|.....:|..|..:.              |.|| .|:...|.:.:|..:.
  Rat   724 FLLESTMNEYIEQRKPCDTMKVGGNLDSKG--------------YGVA-TPKGSSLRNAVNLAVL 773

  Fly   567 SWHSSGFDKYWEYRVVADNLNLKIQQQVQETMTG---TKDIGPVPLGMSNFAGFIIVWILGSAIA 628
            ..:..|         :.|.|..|......|..:|   :|| ....|.:||.||...:.:.|..:|
  Rat   774 KLNEQG---------LLDKLKNKWWYDKGECGSGGGDSKD-KTSALSLSNVAGVFYILVGGLGLA 828

  Fly   629 TLTFLLE 635
            .|..|:|
  Rat   829 MLVALIE 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir41a	NP_995744.4	None
Gria4	NP_001106655.1	PBP1_iGluR_AMPA_GluR4	28..398	CDD:107383	53/289 (18%)
		ANF_receptor	39..380	CDD:279440	50/271 (18%)
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	82/438 (19%)
		Lig_chan	546..825	CDD:278489	62/321 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350113
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840