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Protein Alignment Ir41a and GRIN2D

DIOPT Version :9

Sequence 1:	NP_995744.4	Gene:	Ir41a / 2768714	FlyBaseID:	FBgn0040849	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_000827.2	Gene:	GRIN2D / 2906	HGNCID:	4588	Length:	1336	Species:	Homo sapiens

Alignment Length:	681	Identity:	126/681 - (18%)
Similarity:	223/681 - (32%)	Gaps:	232/681 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GKYLNESTICIFWNDKFEFQLLHKSDYISFVGINIKSFDDNGGHYIIDTGLKKKELQNKHLFLDE 80
            |:.|:...:.|.|:::         ||         ||:::|  ::::..|
Human   357 GESLHRYFMNITWDNR---------DY---------SFNEDG--FLVNPSL-------------- 387

  Fly    81 LVIKIIISIEVTHCETFVVFDKDIDRFVNAFNKASV---YSIWRSLHNKFVFAHIANESPESRNH 142
                ::||:  |...|:.|        |.::.:.::   |.:| |.:.:|:      :..:...|
Human   388 ----VVISL--TRDRTWEV--------VGSWEQQTLRLKYPLW-SRYGRFL------QPVDDTQH 431

  Fly   143 F----FEDQPNILFVVRDHSSASSF--DIKTNKFVGRKAENPSQMILVDRYLASEQRFQFGKSLF 201
            .    .|::|.::....|..|.:..  .:.....:.|....|..        |.....:..|...
Human   432 LTVATLEERPFVIVEPADPISGTCIRDSVPCRSQLNRTHSPPPD--------APRPEKRCCKGFC 488

  Fly   202 ADKLNNLQGREVIIAGFDYPPYTVIKHNMSTNAQDMGVSGESDFKNVYIDGTETRIVLNFCEQFN 266
            .|.|..|    ....||.|..|.|      ||    |..|:.      |||.
Human   489 IDILKRL----AHTIGFSYDLYLV------TN----GKHGKK------IDGV------------- 520

  Fly   267 CTIQIDSSAANDWGKVYPNMSGDGALGMLINRKADICIGAMYSWYEDYTYLDLSMYLVRSGITCL 331
                        |         :|.:|.:..::||:.||::....|....:|.|:..|.:||:.:
Human   521 ------------W---------NGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVM 564

  Fly   332 VPAPLRLTSWYLPLEPFKETLWAAI-LLCLCAEA-TGLVLAYKSEQAL--YVLPGYREGWWTCT- 391
            |.......|....|||:...:|..: ::||...| |..:..|.|....  .:..|.|.|..|.|
Human   565 VARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGGSTFTI 629

  Fly   392 SFGVCTTFKLFISQS---GNSKAYSLTVRVLLFACFLNDLIITSIYGGGLASILTIPSMDEAADT 453
            ...:...:.|..:.|   .|.:..:..:.||::|.|.  :|..:.|...||:.:.   .:|..||
Human   630 GKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFA--VIFLASYTANLAAFMI---QEEYVDT 689

  Fly   454 VTRL---RFHRLQWAANSEAWVSAIRASDEALVKDILYNFHIYSDDELLRLAQDQHMRIGFTVER 515
            |:.|   :|.|.|.......:.:....|.|..::....:.|.|    ::|..|.   |:...:.:
Human   690 VSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSY----MVRYNQP---RVEEALTQ 747

  Fly   516 LPFGHF-------AIGNYLG----------------------------------PQAIDQLVIMK 539
            |..|..       |:.||:.                                  |..:..|..:.
Human   748 LKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLG 812

  Fly   540 DDIYFQYTVAFVPRLWPLLDKLNTLIYSWHSSGFDKYWEYRVVADNLNLKIQQQVQETMTGTKDI 604
            ||     .:..:.|||     |:.:.:                    |.||     |.|:...||
Human   813 DD-----EIEMLERLW-----LSGICH--------------------NDKI-----EVMSSKLDI 842

  Fly   605 GPVPLGMSNFAGFIIVWILGSAIATLTFLLE 635
                   .|.||...:.::...::.|.|..|
Human   843 -------DNMAGVFYMLLVAMGLSLLVFAWE 866

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.