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Protein Alignment Ir41a and GRIN2B

DIOPT Version :9

Sequence 1:	NP_995744.4	Gene:	Ir41a / 2768714	FlyBaseID:	FBgn0040849	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_000825.2	Gene:	GRIN2B / 2904	HGNCID:	4586	Length:	1484	Species:	Homo sapiens

Alignment Length:	598	Identity:	117/598 - (19%)
Similarity:	220/598 - (36%)	Gaps:	151/598 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 KASVYSIWRSLHNKFVF------AHIANESPESRN-HFFED----QPNILFVVRDHSSASSFDIK 166
            |:|.|    :.|.|.::      .::.|.:.|.|| .|.||    .|.::.::.:         |
Human   318 KSSCY----NTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDGYQMHPKLVIILLN---------K 369

  Fly   167 TNKF--VGRKAENPSQMILVDRYLASEQRFQFGKSLFADKLNNLQGRE---VIIAGFDYPPYTVI 226
            ..|:  ||:..:...||    :|....:.....:....|.|:.:...|   ||:...|....|.:
Human   370 ERKWERVGKWKDKSLQM----KYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVESVDPLSGTCM 430

  Fly   227 KHNMSTNAQDMGVSGESDFKNVYIDGTETRIVLNFCEQFNCTIQIDSSAANDW-------GKVYP 284
            ::.:....: :....::|.:..||    .:....||  .:...:|..|....:       ||...
Human   431 RNTVPCQKR-IVTENKTDEEPGYI----KKCCKGFC--IDILKKISKSVKFTYDLYLVTNGKHGK 488

  Fly   285 NMSG--DGALGMLINRKADICIGAMYSWYEDYTYLDLSMYLVRSGITCLVPAPLRLTSWYLPLEP 347
            .::|  :|.:|.::.::|.:.:|::....|....:|.|:..:.:||:.:|.......|....|||
Human   489 KINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTVSPSAFLEP 553

  Fly   348 FKETLWAAILLCLCAEATGLVLAYKSEQALYVLP-GYREGWWTCTSFG-------------VCTT 398
            |...:|..:.:.|...:...|..::     |..| ||..    |.:.|             :...
Human   554 FSADVWVMMFVMLLIVSAVAVFVFE-----YFSPVGYNR----CLADGREPGGPSFTIGKAIWLL 609

  Fly   399 FKLFISQS---GNSKAYSLTVRVLLFACFLNDLIITSIYGGGLASILTIPSMDEAADTVTRL--- 457
            :.|..:.|   .|.|..:..:.|.::|.|.  :|..:.|...||:.:.   .:|..|.|:.|
Human   610 WGLVFNNSVPVQNPKGTTSKIMVSVWAFFA--VIFLASYTANLAAFMI---QEEYVDQVSGLSDK 669

  Fly   458 RFHRLQWAANSEAWVSAIRASDEALVKDILYNFHIYS--------DDELLRLAQDQHMRIG---- 510
            :|.|....:....:.:....|.|..:::.....|.|.        ||.||.|      :.|
Human   670 KFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGVDDALLSL------KTGKLDA 728

  Fly   511 FTVERLPFGHFAIGNYL-GPQAIDQLVIMKDDIYFQYTVAFVPRLWPLLDKLNTLIYSWHSSGF- 573
            |..:.      |:.||: |.....:||.:.....|.                        |:|:
Human   729 FIYDA------AVLNYMAGRDEGCKLVTIGSGKVFA------------------------STGYG 763

  Fly   574 -----DKYWEYRVVADNLNLKIQQQVQET----MTG-----TKDIGPVPLGMSNFAGFIIVWILG 624
                 |..|:.:|....|.|....:::|.    :||     ..::....|.:.|.||  :.::||
Human   764 IAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAG--VFYMLG 826

  Fly   625 SAIA--TLTFLLE 635
            :|:|  .:||:.|
Human   827 AAMALSLITFICE 839

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.