DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir41a and GRIN2B

DIOPT Version :10

Sequence 1:NP_995744.4 Gene:Ir41a / 2768714 FlyBaseID:FBgn0040849 Length:648 Species:Drosophila melanogaster
Sequence 2:NP_000825.2 Gene:GRIN2B / 2904 HGNCID:4586 Length:1484 Species:Homo sapiens


Alignment Length:598 Identity:117/598 - (19%)
Similarity:220/598 - (36%) Gaps:151/598 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   113 KASVYSIWRSLHNKFVF------AHIANESPESRN-HFFED----QPNILFVVRDHSSASSFDIK 166
            |:|.|    :.|.|.::      .::.|.:.|.|| .|.||    .|.::.::.:         |
Human   318 KSSCY----NTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDGYQMHPKLVIILLN---------K 369

  Fly   167 TNKF--VGRKAENPSQMILVDRYLASEQRFQFGKSLFADKLNNLQGRE---VIIAGFDYPPYTVI 226
            ..|:  ||:..:...||    :|....:.....:....|.|:.:...|   ||:...|....|.:
Human   370 ERKWERVGKWKDKSLQM----KYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVESVDPLSGTCM 430

  Fly   227 KHNMSTNAQDMGVSGESDFKNVYIDGTETRIVLNFCEQFNCTIQIDSSAANDW-------GKVYP 284
            ::.:....: :....::|.:..||    .:....||  .:...:|..|....:       ||...
Human   431 RNTVPCQKR-IVTENKTDEEPGYI----KKCCKGFC--IDILKKISKSVKFTYDLYLVTNGKHGK 488

  Fly   285 NMSG--DGALGMLINRKADICIGAMYSWYEDYTYLDLSMYLVRSGITCLVPAPLRLTSWYLPLEP 347
            .::|  :|.:|.::.::|.:.:|::....|....:|.|:..:.:||:.:|.......|....|||
Human   489 KINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTVSPSAFLEP 553

  Fly   348 FKETLWAAILLCLCAEATGLVLAYKSEQALYVLP-GYREGWWTCTSFG-------------VCTT 398
            |...:|..:.:.|...:...|..::     |..| ||..    |.:.|             :...
Human   554 FSADVWVMMFVMLLIVSAVAVFVFE-----YFSPVGYNR----CLADGREPGGPSFTIGKAIWLL 609

  Fly   399 FKLFISQS---GNSKAYSLTVRVLLFACFLNDLIITSIYGGGLASILTIPSMDEAADTVTRL--- 457
            :.|..:.|   .|.|..:..:.|.::|.|.  :|..:.|...||:.:.   .:|..|.|:.|   
Human   610 WGLVFNNSVPVQNPKGTTSKIMVSVWAFFA--VIFLASYTANLAAFMI---QEEYVDQVSGLSDK 669

  Fly   458 RFHRLQWAANSEAWVSAIRASDEALVKDILYNFHIYS--------DDELLRLAQDQHMRIG---- 510
            :|.|....:....:.:....|.|..:::.....|.|.        ||.||.|      :.|    
Human   670 KFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGVDDALLSL------KTGKLDA 728

  Fly   511 FTVERLPFGHFAIGNYL-GPQAIDQLVIMKDDIYFQYTVAFVPRLWPLLDKLNTLIYSWHSSGF- 573
            |..:.      |:.||: |.....:||.:.....|.                        |:|: 
Human   729 FIYDA------AVLNYMAGRDEGCKLVTIGSGKVFA------------------------STGYG 763

  Fly   574 -----DKYWEYRVVADNLNLKIQQQVQET----MTG-----TKDIGPVPLGMSNFAGFIIVWILG 624
                 |..|:.:|....|.|....:::|.    :||     ..::....|.:.|.||  :.::||
Human   764 IAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAG--VFYMLG 826

  Fly   625 SAIA--TLTFLLE 635
            :|:|  .:||:.|
Human   827 AAMALSLITFICE 839

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir41aNP_995744.4 None
GRIN2BNP_000825.2 PBP1_iGluR_NMDA_NR2 33..388 CDD:380601 19/86 (22%)
PBP2_iGluR_NMDA_Nr2 403..803 CDD:270436 86/456 (19%)
Pore-forming. /evidence=ECO:0000250|UniProtKB:A7XY94 604..623 2/18 (11%)
NMDAR2_C 840..1484 CDD:463148 117/598 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1074..1097
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1161..1194
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1271..1301
Interaction with DAPK1. /evidence=ECO:0000250|UniProtKB:Q01097 1292..1304
PDZ-binding. /evidence=ECO:0000250 1482..1484
Blue background indicates that the domain is not in the aligned region.

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