DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir41a and GRIK4

DIOPT Version :9

Sequence 1:	NP_995744.4	Gene:	Ir41a / 2768714	FlyBaseID:	FBgn0040849	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_001269399.1	Gene:	GRIK4 / 2900	HGNCID:	4582	Length:	956	Species:	Homo sapiens

Alignment Length:	772	Identity:	151/772 - (19%)
Similarity:	250/772 - (32%)	Gaps:	235/772 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 AIVG--KYLNESTICIFWN--------DKFEFQLLHKSDYISFVGINIKSFDDNGGHYIIDTGLK 67
            |:.|  .:.|.:|.|:...        :|...|.|...|.:|     ::..||...    .|.|.
Human   149 AVAGILNFFNCTTACLICAKAECLLNLEKLLRQFLISKDTLS-----VRMLDDTRD----PTPLL 204

  Fly    68 KKELQNK-------------HLFLDELVIKIIISIEVTHCETFVVF-----DKDIDRFVNAFNKA 114
            |:...:|             |..|.:.....::|...|:..|.:.|     |..:|..||...
Human   205 KEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILG-- 267

  Fly   115 SVYSIWRSLHNKF-VFAHIANESPESRNHFFEDQPNILFVVRDHSSASSFDIKTNKFVGRKAENP 178
              :||:...|..| .||...|:|      :.|:..::.|.....|||..||.........:..|.
Human   268 --FSIFNQSHAFFQEFAQSLNQS------WQENCDHVPFTGPALSSALLFDAVYAVVTAVQELNR 324

  Fly   179 SQMILVDRY-LASEQRFQFGKSL--------------------------FADKL----------- 205
            ||.|.|... ..|.|.:|.|.||                          :|.|:
Human   325 SQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALKILQFTRNGFRQI 389

  Fly   206 ---------------------NNLQGREVIIAGFDYPPYTVIKHNMSTNAQDMGVSGESDFKNVY 249
                                 :.|....:::......||.::|    .|.|:|  .|...::...
Human   390 GQWHVAEGLSMDSHLYASNISDTLFNTTLVVTTILENPYLMLK----GNHQEM--EGNDRYEGFC 448

  Fly   250 IDGTETRIVLNFCE--QFNCTIQIDSSAANDWGKVYPNMSGDGALGMLINRKADICIGAMYSWYE 312
            :|     ::....|  :||..|::.....  :|....|.:..|.:|.||.||||:.:..:....|
Human   449 VD-----MLKELAEILRFNYKIRLVGDGV--YGVPEANGTWTGMVGELIARKADLAVAGLTITAE 506

  Fly   313 DYTYLDLSMYLVRSGITCLVPAPL-RLTSWYLPLEPFKETLWAAILLCLCAEATGLVLAYKSEQA 376
            ....:|.|...:..||:.|....: |...::..|:||...:|..:||...|.:..|.|..:
Human   507 REKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVAR---- 567

  Fly   377 LYVLPGYREGWWT---CTSFGVCTTFKLFISQ--SGNS----------KAYSLTVRVLLFAC--- 423
               |..|.  |::   |.. |.|   .|.::|  .|||          :..::..|.|...|
Human   568 ---LTPYE--WYSPHPCAQ-GRC---NLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSG 623

  Fly   424 --FLNDLIITSIYGGGLASILTIPSMDEAADTVTRLR------------------FHRLQWAANS 468
              :...|||.|.|...||:.||:..||...::|..|.                  |...::....
Human   624 VWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQ 688

  Fly   469 EAW--------VSAIRASDEALVKDILYNFHIYSDDELLRLAQDQHMR--------IGFTVERLP 517
            ..|        ...:::::|.:.:.:..|:..     ||....:::.|        ||..::...
Human   689 RMWNYMYSKQPSVFVKSTEEGIARVLNSNYAF-----LLESTMNEYYRQRNCNLTQIGGLLDTKG 748

  Fly   518 FGHFAIGNYLGPQAIDQLVIMKDDIYFQYTVAFVPRLWPLLDKLNTLIYSWHSSGFDKYWEYRVV 582
            :|   ||..:|....|:..:....:.....:..:.|.|            |......|..::|..
Human   749 YG---IGMPVGSVFRDEFDLAILQLQENNRLEILKRKW------------WEGGKCPKEEDHRAK 798

  Fly   583 ADNLNLKIQQQVQETMTGTKDIGPVPLGMSNFAGFIIVWILGSAIATLTFLLELSLT 639
            .                         |||.|..|..:|.|.|..:|....:||...|
Human   799 G-------------------------LGMENIGGIFVVLICGLIVAIFMAMLEFLWT 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir41a	NP_995744.4	None
GRIK4	NP_001269399.1	PBP1_iGluR_Kainate_KA1_2	26..400	CDD:107389	54/269 (20%)
		ANF_receptor	43..382	CDD:279440	54/251 (22%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	81/415 (20%)
		Lig_chan	547..816	CDD:278489	59/326 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..889
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155774
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840