Protein Alignment Ir41a and GRIK3

DIOPT Version :9

• Sequence 1: NP_995744.4
• Gene: Ir41a / 2768714
• FlyBaseID: FBgn0040849
• Length: 648
• Species: Drosophila melanogaster
• Sequence 2: NP_000822.2
• Gene: GRIK3 / 2899
• HGNCID: 4581
• Length: 919
• Species: Homo sapiens
• Alignment Length: 589
• Identity: 107/589 - (18%)
• Similarity: 197/589 - (33%)
• Gaps: 154/589 - (26%)

  Fly   106 RFVNAFNKASVYSIWRSLHNKFVFAHIANESPESRNHFFEDQPNILFVVRD-------HSSASSF 163
            ||:|...:|.    |..|..:.||    |::...|..|..|   |:.:..|       .|.|...
Human   361 RFMNFIKEAQ----WEGLTGRIVF----NKTSGLRTDFDLD---IISLKEDGLEKVGVWSPADGL 414

  Fly   164 DIKTNKFVGRKAENPSQMILVDRYLASEQRFQFGKSLFADKLNNLQGREVIIAGFDYPPYTVIKH 228
            :| |....||   .|:                     ..|.|.|   |.:|:......|:.:.:.
Human   415 NI-TEVAKGR---GPN---------------------VTDSLTN---RSLIVTTVLEEPFVMFRK 451

  Fly   229 NMSTNAQDMGVSGESDFKNVYID-GTETRIVLNFCEQFNCTIQIDSSAANDWGKVYPNMSGDGAL 292
            :      |..:.|...|:...|| ..|...:|.|..:..........|.:|.|:      .:|.:
Human   452 S------DRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQ------WNGMV 504

  Fly   293 GMLINRKADICIGAMYSWYEDYTYLDLSMYLVRSGITCLVPAPLRLT-SWYLPLEPFKETLWAAI 356
            ..||:.|||:.:..:...:.....:|.|...:..|::.|...|.... |.:..|.|....:|..:
Human   505 KELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYV 569

  Fly   357 LLC-LCAEATGLVLA----YKSEQALYVLPGYR---------EGWWTCTSFGVCTTFKLFISQSG 407
            ||. |.......|:|    |:...|....||..         ..:|    ||:.:    .:.|..
Human   570 LLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFW----FGMGS----LMQQGS 626

  Fly   408 NSKAYSLTVRVLLFACFLNDLIITSIYGGGLASILTIPSMDEAADTV------TRLRFHRLQ--- 463
            .....:|:.|::....:...|||.|.|...||:.||:..|:...|:.      |::.:..::
Human   627 ELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGA 691

  Fly   464 ----------------WAANSEAWVSAIRASDEALVKDILYNFHIYSDDELLRLAQDQH---MRI 509
                            ||..|....:.::.::|.:.:.:..::.:..:...:.....::   .:|
Human   692 TMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQI 756

  Fly   510 GFTVERLPFGHFAIGNYLGPQAIDQLVIMKDDIYFQYTVAFVPRLWPLLDKLNTLIYSWHSSGFD 574
            |..::...:|   ||..:|....|::.|....:..:..:..:...|            |..||..
Human   757 GGLIDSKGYG---IGTPMGSPYRDKITIAILQLQEEDKLHIMKEKW------------WRGSGCP 806

  Fly   575 KYWEYRVVADNLNLKIQQQVQETMTGTKDIGPVPLGMSNFAGFIIVWILGSAIATLT----FLLE 635
                            :::.:|...         ||:....|..||...|..::.|.    |:.:
Human   807 ----------------EEENKEASA---------LGIQKIGGIFIVLAAGLVLSVLVAVGEFVYK 846

  Fly   636 LSLT 639
            |..|
Human   847 LRKT 850

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir41a	NP_995744.4	None
GRIK3	NP_000822.2	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	17/67 (25%)
		ANF_receptor	55..398	CDD:279440	13/47 (28%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	70/405 (17%)
		Lig_chan	564..832	CDD:278489	50/315 (16%)
		Glutamate binding. /evidence=ECO:0000250	690..692		0/1 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156182
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840