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Protein Alignment Ir41a and GRIK2

DIOPT Version :9

Sequence 1:	NP_995744.4	Gene:	Ir41a / 2768714	FlyBaseID:	FBgn0040849	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_068775.1	Gene:	GRIK2 / 2898	HGNCID:	4580	Length:	908	Species:	Homo sapiens

Alignment Length:	485	Identity:	94/485 - (19%)
Similarity:	166/485 - (34%)	Gaps:	118/485 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 QFGKSLFADKLNNLQGREVIIAGFDYPPYTVIKHNMSTNAQDMGVSGESDFKNVYID-GTETRIV 258
            |.||.  |:..::|..|.:|:......||.:.|.:      |..:.|...|:...|| ..|...:
Human   417 QKGKP--ANITDSLSNRSLIVTTILEEPYVLFKKS------DKPLYGNDRFEGYCIDLLRELSTI 473

  Fly   259 LNFCEQFNCTIQIDSSAANDWGKVYPNMSGDGALGMLINRKADICIGAMYSWYEDYTYLDLSMYL 323
            |.|..:..........|.:|     .|...:|.:..||:.|||:.:..:...|.....:|.|...
Human   474 LGFTYEIRLVEDGKYGAQDD-----ANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPF 533

  Fly   324 VRSGITCLVPAP----LRLTSWYLPLEPFKETLWAAILLCLCAEATGLVLAYKSEQ-ALYVLPGY 383
            :..||:.|...|    ..:.|:..||.|   .:|..||           |||.... .|:|:..:
Human   534 MTLGISILYRKPNGTNPGVFSFLNPLSP---DIWMYIL-----------LAYLGVSCVLFVIARF 584

  Fly   384 REGWW----TC--------TSFGVCTTF----KLFISQSGNSKAYSLTVRVLLFACFLNDLIITS 432
            ....|    .|        .:|.:..:|    ...:.|.......:|:.|::....:...|||.|
Human   585 SPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIIS 649

  Fly   433 IYGGGLASILTIPSMDEAADTV------TRLRFHRLQ-------------------WAANSEAWV 472
            .|...||:.||:..|:...|:.      |::.:..::                   ||..|....
Human   650 SYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQ 714

  Fly   473 SAIRASDEALVKDIL---YNFHIYSDD-ELLRLAQDQHMRIGFTVERLPFGHFAIGNYLGPQAID 533
            |.:..|:|..::.:|   |.|.:.|.. |.:........:||..::...:|   :|..:|....|
Human   715 SVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYG---VGTPMGSPYRD 776

  Fly   534 QLVIMKDDIYFQYTVAFVPRLWPLLDKLNTLIYSWHSSGFDKYWEYRVVADNLNLKIQQQVQETM 598
            ::.|....:..:..:..:...|            |..:|..                :::.:|..
Human   777 KITIAILQLQEEGKLHMMKEKW------------WRGNGCP----------------EEESKEAS 813

  Fly   599 TGTKDIGPVPLGMSNFAGFIIVWILGSAIA 628
            .         ||:.|..|..||...|..::
Human   814 A---------LGVQNIGGIFIVLAAGLVLS 834

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.