DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir41a and GRIK1

DIOPT Version :9

Sequence 1:NP_995744.4 Gene:Ir41a / 2768714 FlyBaseID:FBgn0040849 Length:648 Species:Drosophila melanogaster
Sequence 2:NP_001317923.1 Gene:GRIK1 / 2897 HGNCID:4579 Length:949 Species:Homo sapiens


Alignment Length:602 Identity:107/602 - (17%)
Similarity:201/602 - (33%) Gaps:156/602 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   106 RFVNAFNKASVYSIWRSLHNKFVFAHIANESPESRNHFFEDQPNILFVVRDHSSASSFDI----- 165
            ||:|...:|.    |..|.....|    |::...|..|..|   |:.:..:.:..::.::     
Human   359 RFMNLIKEAR----WDGLTGHITF----NKTNGLRKDFDLD---IISLKEEGTEKAAGEVSKHLY 412

  Fly   166 KTNKFVGRKAENPSQMILVDRYLASEQRFQFGKSLFADKLNNLQGREVIIAGFDYPPYTVIKHNM 230
            |..|.:|....| |.:.:.|.          .|...::..::|..|.:|:......||.:.:.: 
Human   413 KVWKKIGIWNSN-SGLNMTDS----------NKDKSSNITDSLANRTLIVTTILEEPYVMYRKS- 465

  Fly   231 STNAQDMGVSGESDFKNVYID-GTETRIVLNFCEQFNCTIQIDSSAANDWGKVYPNMSGDGALGM 294
                 |..:.|...|:...:| ..|...:|.|.............|.||.|:      .:|.:..
Human   466 -----DKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKGE------WNGMVKE 519

  Fly   295 LINRKADICIGAMYSWYEDYTYLDLSMYLVRSGITCLVPAP----LRLTSWYLPLEPFKETLWAA 355
            ||:.:||:.:..:...|.....:|.|...:..||:.|...|    ..:.|:..||.|   .:|..
Human   520 LIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSP---DIWMY 581

  Fly   356 ILL-CLCAEATGLVLAYKSEQALYVLPGYREGWW----TC--------TSFGVCTTF----KLFI 403
            :|| ||....           .|:|:..:....|    .|        .:|.:..:|    ...:
Human   582 VLLACLGVSC-----------VLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALM 635

  Fly   404 SQSGNSKAYSLTVRVLLFACFLNDLIITSIYGGGLASILTIPSMDEAADTV------TRLRF--- 459
            .|.......:|:.|::....:...|||.|.|...||:.||:..|:...|:.      |::.:   
Human   636 QQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAV 700

  Fly   460 ----------------HRLQWA-ANSEAWVSAIRASDEALVKDILYNFHIYSDDELLRLAQDQH- 506
                            :...|| .:|....:.:|.|||.:.:.:..::.:..:...:.....:: 
Human   701 RDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQRNC 765

  Fly   507 --MRIGFTVERLPFGHFAIGNYLGPQAIDQLVIMKDDIYFQYTVAFVPRLWPLLDKLNTLIYSWH 569
              .:||..::...:|   :|..:|.                          |..||:...|....
Human   766 NLTQIGGLIDSKGYG---VGTPIGS--------------------------PYRDKITIAILQLQ 801

  Fly   570 SSG-----FDKYWEYRVVADNLNLKIQQQVQETMTGTKDIGPVPLGMSNFAGFIIVWILGSAIAT 629
            ..|     .:|:|......:..|.:..                .||:.|..|..||...|..::.
Human   802 EEGKLHMMKEKWWRGNGCPEEDNKEAS----------------ALGVENIGGIFIVLAAGLVLSV 850

  Fly   630 LTFLLELSLTYILKQSN 646
            ...:.|  ..|..:::|
Human   851 FVAIGE--FIYKSRKNN 865

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ir41aNP_995744.4 None
GRIK1NP_001317923.1 Periplasmic_Binding_Protein_Type_1 35..430 CDD:324556 17/82 (21%)
Periplasmic_Binding_Protein_Type_2 446..815 CDD:328725 75/423 (18%)
Glutamate binding. /evidence=ECO:0000250 531..533 0/1 (0%)