Protein Alignment Ir41a and GRID1

DIOPT Version :10

• Sequence 1: NP_995744.4
• Gene: Ir41a / 2768714
• FlyBaseID: FBgn0040849
• Length: 648
• Species: Drosophila melanogaster
• Sequence 2: NP_060021.1
• Gene: GRID1 / 2894
• HGNCID: 4575
• Length: 1009
• Species: Homo sapiens
• Alignment Length: 774
• Identity: 142/774 - (18%)
• Similarity: 250/774 - (32%)
• Gaps: 250/774 - (32%)

  Fly    26 IFWNDKFEFQLLHK-SDYISFVG--INIKSFDDNGGHYI--IDTGLKKKEL-------------- 71
            :|::.:::.:.|.. .|..|.:|  ::::..|.|..|..  :.|.:|.:||
Human   167 MFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELNRYRDTLRRAILLL 231

  Fly    72 --QNKHLFLDELVIKIIIS-----------------IEVTH------------------------ 93
              |..|.|::|.|...:.|                 :::.|
Human   232 SPQGAHSFINEAVETNLASKDSHWVFVNEEISDPEILDLVHSALGRMTVVRQIFPSAKDNQKCTR 296

  Fly    94 ---------CE------------TFVVFDKDIDRFVNAFNK----------ASVYSI------W- 120
                     |:            ...::| .:....|||::          ||:..|      |
Human   297 NNHRISSLLCDPQEGYLQMLQISNLYLYD-SVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWN 360

  Fly   121 --RSLHNKFVFAHIANESPESRNHFFED--QPNILFVVRDHSSASSFDIKTNKFVGRKAENPSQM 181
              ||:.:.....||...:  ....|.||  .|.:.|.:...:.:.:|.....|.....:|.....
Human   361 GGRSMLDTIKKGHITGLT--GVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKGLNG 423

  Fly   182 ILVDRYLASEQRFQFGKSLFADKLNNLQGREVIIAGFDYPPYTVIKHNMSTNAQDMGVSGESDFK 246
            .|.:|.:.|                .|||..:.:......|:.::..|:        :.....:|
Human   424 SLQERPMGS----------------RLQGLTLKVVTVLEEPFVMVAENI--------LGQPKRYK 464

  Fly   247 NVYIDGTETRIVLN-FCEQFNCTIQIDSSAANDWGKVYPNMSGDGALGMLINRKADICIGAMYSW 310
            ...||      ||: ..:......:|..:....:|....|.|.:|.:|.||:::||:.|.|:...
Human   465 GFSID------VLDALAKALGFKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITIT 523

  Fly   311 YEDYTYLDLSMYLVRSGITCLVPAPLRLTSWYLPLEPFKETLWAAILLCLCAEATGLVL------ 369
            .|..:.:|.|...:...:..|:..|....|.:....||...:||.|...:  ...|:::
Human   524 PERESVVDFSKRYMDYSVGILIKKPEEKISIFSLFAPFDFAVWACIAAAI--PVVGVLIFVLNRI 586

  Fly   370 -AYKSEQALYVLPGYREGWWTCTSFGVCTTFKLFISQSGNSKAYSLTVRVLLFACFLNDLIITSI 433
             |.:::.|....|....   |..| .:...:..|:.|.|.|...|:.:|:::.:.:|..||:.|.
Human   587 QAVRAQSAAQPRPSASA---TLHS-AIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSS 647

  Fly   434 YGGGLASILTIPSMDEAADTVTRL-----------------RFHRL-------QWAANSEAW--V 472
            |...||:.||:..||....|...|                 .:.|.       |.:..:|.|  :
Human   648 YTANLAAFLTVSRMDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTI 712

  Fly   473 SAIRASDEALVKDILYNFHIYSDDELLRLAQDQHMRIGFTVERLPFGHFAIGNYLGPQAIDQLVI 537
            |....:|..          :.|..|.:|.|:.              |::|   :|...|:.:...
Human   713 SKNGGADNC----------VSSPSEGIRKAKK--------------GNYA---FLWDVAVVEYAA 750

  Fly   538 MKDD-----------------IYFQ----YTVAFVPRLWPLLD--KLNTLIYSW--HSSGFDKYW 577
            :.||                 |..|    |...|..|:..|.|  .|:.|...|  |....|...
Human   751 LTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTS 815

  Fly   578 EYRVVADNLNLKIQQQVQETMTGTKDIGPVPLGMSNFAGFIIVWILGSAIATLTFLLEL 636
            .....||..:||:.                     :|||...:..:|..:|.|...|||
Human   816 HASAQADGKSLKLH---------------------SFAGVFCILAIGLLLACLVAALEL 853

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir41a	NP_995744.4	None
GRID1	NP_060021.1	Interaction with CBLN1. /evidence=ECO:0000250|UniProtKB:Q61627	21..436		44/287 (15%)
		PBP1_iGluR_delta_1	25..425	CDD:380615	40/260 (15%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	82/416 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	930..954