Protein Alignment Ir41a and GRIA4

DIOPT Version :10

• Sequence 1: NP_995744.4
• Gene: Ir41a / 2768714
• FlyBaseID: FBgn0040849
• Length: 648
• Species: Drosophila melanogaster
• Sequence 2: NP_000820.4
• Gene: GRIA4 / 2893
• HGNCID: 4574
• Length: 902
• Species: Homo sapiens
• Alignment Length: 788
• Identity: 152/788 - (19%)
• Similarity: 252/788 - (31%)
• Gaps: 280/788 - (35%)

  Fly    10 VLSAIVGKY----LNESTICI-FWNDKFEFQLLHKSD---------------------YISFVGI 48
            :|.||:.|.    .:.|.||: .:||....|||.:.|                     .|..||.
Human   166 ILQAIMEKAGQNGWHVSAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGK 230

  Fly    49 NIKSFDDNGGHYII-DTGLKKKELQNKHLFLDELVIKIIISIEVTHCETFVVFDKDIDRFVNA-- 110
            ::|     |.|||| :.|.|                                 |..::||::.
Human   231 HVK-----GYHYIIANLGFK---------------------------------DISLERFIHGGA 257

  Fly   111 ---------FNKASVYSI---WRSLHNKFVFAHIANESPESRNHFFEDQPNILFVVRDHSSASSF 163
                     ||...|..:   |:.|..:        |.|.|     |..|.       ::||.::
Human   258 NVTGFQLVDFNTPMVIKLMDRWKKLDQR--------EYPGS-----ETPPK-------YTSALTY 302

  Fly   164 D-----------IKTNKF-VGRKAE------NPS----QMILVDRYLAS---------------E 191
            |           ::..|. :.|:..      ||:    |.|.::|.|..               .
Human   303 DGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHYG 367

  Fly   192 QRFQFGKSLF---------------ADKL----------NN---LQGREVIIAGFDYPPYTVIKH 228
            :|..:...:|               .|||          |:   ::.|.|::......||.:.|.
Human   368 RRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDVPTLGNDTAAIENRTVVVTTIMESPYVMYKK 432

  Fly   229 NMSTNAQDMGVSGESDFKNVYIDGTETRIVLNFCEQFNCTIQIDSS-AAND-----WGKVYPNMS 287
            |     .:| ..|...::...:| ..:.|..:...::...|..|.. .|.|     |
Human   433 N-----HEM-FEGNDKYEGYCVD-LASEIAKHIGIKYKIAIVPDGKYGARDADTKIW-------- 482

  Fly   288 GDGALGMLINRKADICIGAMYSWYEDYTYLDLSMYLVRSGITCLVPAPLRLTSWYLP-LEPFKET 351
             :|.:|.|:..||:|.|..:.........:|.|...:..||:.::..|.:....... |:|....
Human   483 -NGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYE 546

  Fly   352 LWAAILLCLCAEATGLVLAYKSEQALYVLPGYREGWWT--------------CTSFGVCTT--FK 400
            :|..|:....  ...:||...|..:.|       .|.|              ...||:..:  |.
Human   547 IWMCIVFAYI--GVSVVLFLVSRFSPY-------EWHTEEPEDGKEGPSDQPPNEFGIFNSLWFS 602

  Fly   401 L--FISQSGNSKAYSLTVRVLLFACFLNDLIITSIYGGGLASILTIPSM----DEAADTV----- 454
            |  |:.|..:....||:.|::....:...|||.|.|...||:.||:..|    :.|.|..
Human   603 LGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEI 667

  Fly   455 ---------TRLRFHRLQWAANSEAWVSAIRASDEALVKDILYNFHIYSDDELLRLAQDQHMRIG 510
                     |:..|.|.:.|...:.| :.:|:::.::       |...:.:.:.|:.:.:. :..
Human   668 AYGTLDSGSTKEFFRRSKIAVYEKMW-TYMRSAEPSV-------FTRTTAEGVARVRKSKG-KFA 723

  Fly   511 FTVE---------RLPFGHFAIGNYLGPQAIDQLVIMKDDIYFQYTVAFVPRLWPLLDKLNTLIY 566
            |.:|         |.|.....:|..|..:.              |.|| .|:...|...:|..:.
Human   724 FLLESTMNEYIEQRKPCDTMKVGGNLDSKG--------------YGVA-TPKGSSLRTPVNLAVL 773

  Fly   567 SWHSSGFDKYWEYRVVADNLNLKIQQQVQETMTGTKDIG----PVPLGMSNFAGFIIVWILGSAI 627
            ....:|         |.|.|..|......|  .|.||.|    ...|.:||.||...:.:.|..:
Human   774 KLSEAG---------VLDKLKNKWWYDKGE--CGPKDSGSKDKTSALSLSNVAGVFYILVGGLGL 827

  Fly   628 ATLTFLLE 635
            |.|..|:|
Human   828 AMLVALIE 835

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir41a	NP_995744.4	None
GRIA4	NP_000820.4	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	53/291 (18%)
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	84/440 (19%)