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Protein Alignment Ir41a and GRIA2

DIOPT Version :9

Sequence 1:	NP_995744.4	Gene:	Ir41a / 2768714	FlyBaseID:	FBgn0040849	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_000817.5	Gene:	GRIA2 / 2891	HGNCID:	4572	Length:	883	Species:	Homo sapiens

Alignment Length:	708	Identity:	139/708 - (19%)
Similarity:	234/708 - (33%)	Gaps:	207/708 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 DYISFVGINIKSFDDNGGHYII-DTGLKKKELQNKHLFLDELVIKIIISIEVTHCETFVVFDKDI 104
            |.:..:|.::|     |.|||| :.|           |.|..::|  |.....:...|.:.|.|
Human   221 DQVITIGKHVK-----GYHYIIANLG-----------FTDGDLLK--IQFGGANVSGFQIVDYD- 266

  Fly   105 DRFVNAFNKASVYSIWRSLHNKFVFAHIANESPESRNHFFEDQPNILFVVRDHSSASSFD---IK 166
            |..|:.|.:.     |.:|..|                   :.|........::||.::|   :.
Human   267 DSLVSKFIER-----WSTLEEK-------------------EYPGAHTTTIKYTSALTYDAVQVM 307

  Fly   167 TNKF---------VGRKAE------NPS----QMILVDRYLASEQ--------RF-QFGKSL--- 200
            |..|         :.|:..      ||:    |.:.::|.|...|        :| |.||.:
Human   308 TEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYT 372

  Fly   201 ------------------FADKL-------------NNLQGREVIIAGFDYPPYTVIKHNMSTNA 234
                              ..||:             :.|:.:.|::......||.::|.|
Human   373 INIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKN----- 432

  Fly   235 QDMGVSGESDFKNVYIDGTETRIVLNFCEQFNCTIQIDSS-AAND-----WGKVYPNMSGDGALG 293
            .:| :.|...::...:| ....|..:...::..||..|.. .|.|     |         :|.:|
Human   433 HEM-LEGNERYEGYCVD-LAAEIAKHCGFKYKLTIVGDGKYGARDADTKIW---------NGMVG 486

  Fly   294 MLINRKADICIGAMYSWYEDYTYLDLSMYLVRSGITCLVPAPLRLTSWYLP-LEPFKETLWAAIL 357
            .|:..||||.|..:.........:|.|...:..||:.::..|.:....... |:|....:|..|:
Human   487 ELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIV 551

  Fly   358 LCLCAEATGLVLAYKSEQALYVLPGYREGWWTCTS-----FGVCTT--FKL--FISQSGNSKAYS 413
            ......:..|.|..:.....:....:.:|..|.:|     ||:..:  |.|  |:.|..:....|
Human   552 FAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRS 616

  Fly   414 LTVRVLLFACFLNDLIITSIYGGGLASILTIPSM---DEAADTV---------------TRLRFH 460
            |:.|::....:...|||.|.|...||:.||:..|   .|:|:.:               |:..|.
Human   617 LSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFR 681

  Fly   461 RLQWAANSEAWVSAIRASDEALVKDILYNF---------HIYSDDELLRLAQDQHMRIGFTVERL 516
            |.:.|...:.|.....|.....|:......         :.|    ||....::::.     :|.
Human   682 RSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAY----LLESTMNEYIE-----QRK 737

  Fly   517 PFGHFAIGNYLGPQAIDQLVIMKDDIYFQYTVAFVPRLWPLLDKLNTLIYSWHSSGFDKYWEYRV 581
            |.....:|..|..:.              |.:| .|:...|...:|..:......|
Human   738 PCDTMKVGGNLDSKG--------------YGIA-TPKGSSLRTPVNLAVLKLSEQG--------- 778

  Fly   582 VADNLNLKIQQQVQETMTGTKDIG----PVPLGMSNFAGFIIVWILGSAIATLTFLLE 635
            |.|.|..|......|  .|.||.|    ...|.:||.||...:.:.|..:|.|..|:|
Human   779 VLDKLKNKWWYDKGE--CGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIE 834

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.