Protein Alignment Ir41a and Grin2a

DIOPT Version :10

• Sequence 1: NP_995744.4
• Gene: Ir41a / 2768714
• FlyBaseID: FBgn0040849
• Length: 648
• Species: Drosophila melanogaster
• Sequence 2: NP_036705.3
• Gene: Grin2a / 24409
• RGDID: 2737
• Length: 1464
• Species: Rattus norvegicus
• Alignment Length: 251
• Identity: 55/251 - (21%)
• Similarity: 97/251 - (38%)
• Gaps: 32/251 - (12%)

  Fly   226 IKHNMSTNAQDMGVSGESDFKNVYIDGTETRIVLNFCEQFNCTIQIDSSAANDWGKVYPNMSGDG 290
            :|.|.|||.   |::.:...|...||     |:.........|..:........||...|: .:|
  Rat   440 VKINNSTNE---GMNVKKCCKGFCID-----ILKKLSRTVKFTYDLYLVTNGKHGKKVNNV-WNG 495

  Fly   291 ALGMLINRKADICIGAMYSWYEDYTYLDLSMYLVRSGITCLVPAPLRLTSWYLPLEPFKETLWAA 355
            .:|.::.::|.:.:|::....|....:|.|:..|.:||:.:|.......|....||||..::|..
  Rat   496 MIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVM 560

  Fly   356 ILLCLCAEATGLVLAYKSEQALYVLP-GYR---------EGWWTCTSFGVCTTFKLFISQS---G 407
            :.:.|...:...|..::     |..| ||.         .|........:...:.|..:.|   .
  Rat   561 MFVMLLIVSAIAVFVFE-----YFSPVGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQ 620

  Fly   408 NSKAYSLTVRVLLFACFLNDLIITSIYGGGLASILTIPSMDEAADTVTRLRFHRLQ 463
            |.|..:..:.|.::|.|.  :|..:.|...||:.:.   .:|..|.||.|...:.|
  Rat   621 NPKGTTSKIMVSVWAFFA--VIFLASYTANLAAFMI---QEEFVDQVTGLSDKKFQ 671

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir41a	NP_995744.4	None
Grin2a	NP_036705.3	PBP1_iGluR_NMDA_NR2	32..387	CDD:380601
		PBP2_iGluR_NMDA_Nr2	403..802	CDD:270436	55/251 (22%)
		Pore-forming. /evidence=ECO:0000250|UniProtKB:B7ZSK1	599..620		2/20 (10%)
		NMDAR2_C	839..1464	CDD:463148
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	989..1083
		PDZ-binding. /evidence=ECO:0000305	1462..1464