DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir41a and Grin2a

DIOPT Version :9

Sequence 1:NP_995744.4 Gene:Ir41a / 2768714 FlyBaseID:FBgn0040849 Length:648 Species:Drosophila melanogaster
Sequence 2:NP_036705.3 Gene:Grin2a / 24409 RGDID:2737 Length:1464 Species:Rattus norvegicus


Alignment Length:251 Identity:55/251 - (21%)
Similarity:97/251 - (38%) Gaps:32/251 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   226 IKHNMSTNAQDMGVSGESDFKNVYIDGTETRIVLNFCEQFNCTIQIDSSAANDWGKVYPNMSGDG 290
            :|.|.|||.   |::.:...|...||     |:.........|..:........||...|: .:|
  Rat   440 VKINNSTNE---GMNVKKCCKGFCID-----ILKKLSRTVKFTYDLYLVTNGKHGKKVNNV-WNG 495

  Fly   291 ALGMLINRKADICIGAMYSWYEDYTYLDLSMYLVRSGITCLVPAPLRLTSWYLPLEPFKETLWAA 355
            .:|.::.::|.:.:|::....|....:|.|:..|.:||:.:|.......|....||||..::|..
  Rat   496 MIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVM 560

  Fly   356 ILLCLCAEATGLVLAYKSEQALYVLP-GYR---------EGWWTCTSFGVCTTFKLFISQS---G 407
            :.:.|...:...|..::     |..| ||.         .|........:...:.|..:.|   .
  Rat   561 MFVMLLIVSAIAVFVFE-----YFSPVGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQ 620

  Fly   408 NSKAYSLTVRVLLFACFLNDLIITSIYGGGLASILTIPSMDEAADTVTRLRFHRLQ 463
            |.|..:..:.|.::|.|.  :|..:.|...||:.:.   .:|..|.||.|...:.|
  Rat   621 NPKGTTSKIMVSVWAFFA--VIFLASYTANLAAFMI---QEEFVDQVTGLSDKKFQ 671

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir41aNP_995744.4 None
Grin2aNP_036705.3 PBP1_iGluR_NMDA_NR2 32..392 CDD:107373
PBP2_iGluR_NMDA_Nr2 403..802 CDD:270436 55/251 (22%)
HisJ <458..>541 CDD:223904 18/88 (20%)
Glutamate binding. /evidence=ECO:0000269|PubMed:16281028, ECO:0007744|PDB:2A5S, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF4, ECO:0007744|PDB:4NF8, ECO:0007744|PDB:5I56, ECO:0007744|PDB:5I57, ECO:0007744|PDB:5I58, ECO:0007744|PDB:5I59, ECO:0007744|PDB:5JTY 511..513 0/1 (0%)
Lig_chan 556..828 CDD:278489 25/126 (20%)
Pore-forming. /evidence=ECO:0000250|UniProtKB:B7ZSK1 599..620 2/20 (10%)
Glutamate binding. /evidence=ECO:0000269|PubMed:16281028, ECO:0000269|PubMed:24462099, ECO:0007744|PDB:2A5S, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF4, ECO:0007744|PDB:4NF8 689..690
Glutamate binding. /evidence=ECO:0000269|PubMed:16281028, ECO:0000269|PubMed:24462099, ECO:0007744|PDB:2A5S, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF4, ECO:0007744|PDB:4NF8 730..731
NMDAR2_C 839..1464 CDD:287527
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 989..1083
PDZ-binding. /evidence=ECO:0000305 1462..1464
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166349958
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.840

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