DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir41a and Grin3a

DIOPT Version :9

Sequence 1:	NP_995744.4	Gene:	Ir41a / 2768714	FlyBaseID:	FBgn0040849	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_612555.1	Gene:	Grin3a / 191573	RGDID:	621704	Length:	1135	Species:	Rattus norvegicus

Alignment Length:	847	Identity:	163/847 - (19%)
Similarity:	277/847 - (32%)	Gaps:	282/847 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFIDLSWSL----VLSAIVGKYLNES--------------------TICIF-WNDKFEFQ-LLHK 39
            |.:||..|:    |||.:..::..||                    |:.|. .|:.:.|. ||.:
  Rat   207 MELDLVSSVLHIPVLSIVRHEFPRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQ 271

  Fly    40 SDYISFVGINIKSFDDNGGHYIIDTGLKKKELQNKHLFLDELVIKIIISIEVT------------ 92
            .|:      ||..|       ::.|       :|...|..|.||.|..::..|
  Rat   272 EDW------NITDF-------LLLT-------ENNSKFHLESVINITANLSSTKDLLSFLQVQMD 316

  Fly    93 ----HCETFVVFDKDIDRFVNAFNKASVYSI------W-----------RS--------LHNK-- 126
                ...|.|:|..|:|.....|..::.:.:      |           |:        .|.|
  Rat   317 NIRNSTPTMVMFGCDMDSIRQIFEMSTQFGLSPPELHWVLGDSQNVEELRTEGLPLGLIAHGKTT 381

  Fly   127 -FVFAHIANESPESRNHFFED----QPNILFVVRDHSSASSFDIKT-----NKFVGRKAENP--- 178
             .||.:...::.|........    ||.:..:   .|:.:..|:||     .:::.|...|.
  Rat   382 QSVFEYYVQDAMELVARAVATATMIQPELALL---PSTMNCMDVKTTNLTSGQYLSRFLANTTFR 443

  Fly   179 ----SQMILVDRYLASEQRF--------QFGKSLFADKLNNLQGREVII-------------AGF 218
                |..:.....::||..|        ..||.::. :|.:.||..:::             ..|
  Rat   444 GLSGSIKVKGSTIISSENNFFIWNLQHDPMGKPMWT-RLGSWQGGRIVMDSGIWPEQAQRHKTHF 507

  Fly   219 DYP------PYTVIKHN--MSTNAQDMG-----------VSGESD-----FKNVYIDGTETRIVL 259
            .:|      ..|:|:|.  .:....|.|           ::.:|.     |.:::.......|..
  Rat   508 QHPNKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSMLDRLFSSLHSSNDTVPIKF 572

  Fly   260 NFCEQFNCTIQIDSSAANDW-----------GK--VYPNMSGDGALGMLINRKADIC-----IGA 306
            ..|....| |.:....|.|.           ||  .:.|....|.:|.|::..|::.     |..
  Rat   573 KKCCYGYC-IDLLEQLAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLSGTANMAVTSFSINT 636

  Fly   307 MYSWYEDYT--YLDLSM-YLVRSGITCLVPAPLRLTSWYLPLEPFKETLWAAILLCLCAEATGLV 368
            ..|...|:|  :...|: .|||:..|.   ||:....|     |...|:|..|.:.|...|..|.
  Rat   637 ARSQVIDFTSPFFSTSLGILVRTRDTA---APIGAFMW-----PLHWTMWLGIFVALHITAIFLT 693

  Fly   369 LAYKSEQALYVLPGYREGWWTCTSFGVCTTFKLFISQSGNSKAYSL--------------TVRVL 419
            | |:.:....:.|..|            ...|:|...|..:..|:|              |.|.|
  Rat   694 L-YEWKSPFGMTPKGR------------NRNKVFSFSSALNVCYALLFGRTAAIKPPKCWTGRFL 745

  Fly   420 --LFACFLNDLIITSIYGGGLASILTIPSMDEAADTVTRLRFHRLQWAANSEAWVSAIRASDEAL 482
              |:|.|.  :...|.|...||:::....:.|....:...:.|.   .:....:.:...:|.|..
  Rat   746 MNLWAIFC--MFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHH---PSQGFRFGTVRESSAEDY 805

  Fly   483 VKDILYNFHIYSDDELLRLAQDQHMRIGFTVERLPFGHFAIGNYLGPQAIDQLVIMKDDIYFQYT 547
            |:......|             ::|| .:.|...|.|...:.|  .|:.:|..::  |.....|.
  Rat   806 VRQSFPEMH-------------EYMR-RYNVPATPDGVQYLKN--DPEKLDAFIM--DKALLDYE 852

  Fly   548 VAF---------------------VPRLWPLLDKLNTLIYSWHSSGF-----DKYWEYRVVADNL 586
            |:.                     :|...||...::.||..:.|.||     ||:  |:||...
  Rat   853 VSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGFMDVLHDKW--YKVVPCG- 914

  Fly   587 NLKIQQQVQETMTGTKDIGPVPLGMSNFAGFIIVWILGSAIATLTFLLE-----LSLTYILKQSN 646
              |....|.||:         .:|:.:|:|..::..:|..::.||.:.|     |.|..|..:|.
  Rat   915 --KRSFAVTETL---------QMGIKHFSGLFVLLCIGFGLSILTTIGEHIVHRLLLPRIKNKSK 968

  Fly   647 LK 648
            |:
  Rat   969 LQ 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir41a	NP_995744.4	None
Grin3a	NP_612555.1	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	57/313 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..117
		ANF_receptor	127..469	CDD:279440	52/284 (18%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	85/442 (19%)
		Lig_chan	676..942	CDD:278489	62/315 (20%)
		PPP2CB binding site	951..987		6/20 (30%)
		GIT1-binding. /evidence=ECO:0000269\|PubMed:24297929	1082..1115
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350014
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840