DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir41a and gria3a

DIOPT Version :9

Sequence 1:	NP_995744.4	Gene:	Ir41a / 2768714	FlyBaseID:	FBgn0040849	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	XP_005165152.1	Gene:	gria3a / 170452	ZFINID:	ZDB-GENE-020125-5	Length:	903	Species:	Danio rerio

Alignment Length:	500	Identity:	91/500 - (18%)
Similarity:	163/500 - (32%)	Gaps:	122/500 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 YLASEQRFQFGKSLFADKLNNLQGREVIIAGFDYPPYTVIKHNMSTNAQDMGVSGESDFKNVYID 251
            |:..:|        ..::.::::.|.:::......||.:.|.|.      |.:.|...::...:|
Zfish   400 YIVEQQ--------VTNESSSVENRTIVVTTIMEAPYVMYKRNY------MQLEGNDRYEGYCVD 450

  Fly   252 GTETRIVLNFCEQFNCTIQIDSSAANDWGKVYP-NMSGDGALGMLINRKADICIGAMYSWYEDYT 315
                 :.....:......::...|...:|...| ..:.:|.:|.|:..:|||.:..:........
Zfish   451 -----LASEIAKHVGIKYKLSIVADGKYGARDPETKTWNGMVGELVYGRADIAVAPLTITLVREE 510

  Fly   316 YLDLSMYLVRSGITCLVPAPLRLTSWYLP-LEPFKETLWAAILLCLCAEATGLVLAYKSEQALYV 379
            .:|.|...:..||:.::..|.:....... |:|....:|..|:......:..|.|..:.....:.
Zfish   511 VIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWH 575

  Fly   380 LPGYREGWWTCT------SFGVCTT--FKL--FISQSGNSKAYSLTVRVLLFACFLNDLIITSIY 434
            |....|.....|      .||:..:  |.|  |:.|..:....||:.|::....:...|||.|.|
Zfish   576 LDDNEETKDPQTPPDPPNDFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSY 640

  Fly   435 GGGLASILTIPSM----DEAADTV--------------TRLRFHRLQWAANSEAWVSAIRASDEA 481
            ...||:.||:..|    :.|.|..              |:..|.|.:.|...:.|.....|....
Zfish   641 TANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSV 705

  Fly   482 LVKDILYNFHIYSDDELLRLAQDQHMRIGFTVE---------RLPFGHFAIGNYLGPQAIDQLVI 537
            .||.        :.|.:.|:.:.:. :..|.:|         |.|.....:|..|..:.
Zfish   706 FVKT--------TPDGVARVRKSKG-KFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKG------ 755

  Fly   538 MKDDIYFQYTVAFVPRLWPLLDKLNTLIYSWHSSGF-----DKYWEYRVVADNLNLKIQQQVQET 597
                    |.|| .|:...|...:|..:......|.     :|:|                ..:.
Zfish   756 --------YGVA-TPKGSALRTPVNLAVLKLSEQGILDKLKNKWW----------------YDKG 795

  Fly   598 MTGTKDIGP----------VPLGMSNF---------AGFIIVWIL 623
            ..||||.|.          :|..:|.:         |||...|.|
Zfish   796 ECGTKDSGSKVSLLTHLTVLPTNISIYHKHHNEFPVAGFTFFWPL 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir41a	NP_995744.4	None
gria3a	XP_005165152.1	PBP1_iGluR_AMPA_GluR3	28..399	CDD:107382
		ANF_receptor	39..382	CDD:279440
		PBP2_iGluR_AMPA	415..797	CDD:270433	77/432 (18%)
		Lig_chan	547..810	CDD:278489	58/302 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591770
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840