DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir41a and Grin2a

DIOPT Version :9

Sequence 1:	NP_995744.4	Gene:	Ir41a / 2768714	FlyBaseID:	FBgn0040849	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_032196.2	Gene:	Grin2a / 14811	MGIID:	95820	Length:	1464	Species:	Mus musculus

Alignment Length:	252	Identity:	56/252 - (22%)
Similarity:	98/252 - (38%)	Gaps:	35/252 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 IKHNMSTNAQDMGVSGESDFKNVYIDGTETRIVLNFCEQFNCTIQIDSSAANDWGKVYPNMSGDG 290
            :|.|.|||.   |::.:...|...||     |:.........|..:........||...|: .:|
Mouse   440 VKINNSTNE---GMNVKKCCKGFCID-----ILKKLSRTVKFTYDLYLVTNGKHGKKVNNV-WNG 495

  Fly   291 ALGMLINRKADICIGAMYSWYEDYTYLDLSMYLVRSGITCLVPAPLRLTSWYLPLEPFKETLWAA 355
            .:|.::.::|.:.:|::....|....:|.|:..|.:||:.:|.......|....||||..::|..
Mouse   496 MIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVM 560

  Fly   356 ILLCLCAEATGLVLAYKSEQALYVLP-GYR---------EGWWTCTSFGVCTTFKLFISQS---G 407
            :.:.|...:...|..::     |..| ||.         .|........:...:.|..:.|   .
Mouse   561 MFVMLLIVSAIAVFVFE-----YFSPVGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQ 620

  Fly   408 NSKAYSLTVRVLLFACFLNDLIITSIYGGGLASILTIPSMDEAADTVTRL---RFHR 461
            |.|..:..:.|.::|.|.  :|..:.|...||:.:.   .:|..|.||.|   :|.|
Mouse   621 NPKGTTSKIMVSVWAFFA--VIFLASYTANLAAFMI---QEEFVDQVTGLSDKKFQR 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir41a	NP_995744.4	None
Grin2a	NP_032196.2	PBP1_iGluR_NMDA_NR2	32..392	CDD:107373
		PBP2_iGluR_NMDA_Nr2	403..802	CDD:270436	56/252 (22%)
		HisJ	<458..>541	CDD:223904	18/88 (20%)
		Lig_chan	556..828	CDD:278489	26/127 (20%)
		NMDAR2_C	839..1464	CDD:287527
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846467
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840