DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir41a and Grik2

DIOPT Version :9

Sequence 1:	NP_995744.4	Gene:	Ir41a / 2768714	FlyBaseID:	FBgn0040849	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	XP_011241422.1	Gene:	Grik2 / 14806	MGIID:	95815	Length:	943	Species:	Mus musculus

Alignment Length:	509	Identity:	97/509 - (19%)
Similarity:	172/509 - (33%)	Gaps:	131/509 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 QFGKSLFADKLNNLQGREVIIAGFDYPPYTVIKHNMSTNAQDMGVSGESDFKNVYID-GTETRIV 258
            |.||.  |:..::|..|.:|:......||.:.|.:      |..:.|...|:...|| ..|...:
Mouse   417 QKGKP--ANITDSLSNRSLIVTTILEEPYVLFKKS------DKPLYGNDRFEGYCIDLLRELSTI 473

  Fly   259 LNFCEQFNCTIQIDSSAANDWGKVYPNMSGDGALGMLINRKADICIGAMYSWYEDYTYLDLSMYL 323
            |.|..:..........|.:|     .|...:|.:..||:.|||:.:..:...|.....:|.|...
Mouse   474 LGFTYEIRLVEDGKYGAQDD-----VNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPF 533

  Fly   324 VRSGITCLVPAP----LRLTSWYLPLEPFKETLWAAILLC-LCAEATGLVLAYKSEQALYVLP-- 381
            :..||:.|...|    ..:.|:..||.|   .:|..|||. |.......|:|.:|:.:.:..|
Mouse   534 MTLGISILYRKPNGTNPGVFSFLNPLSP---DIWMYILLAYLGVSCVLFVIARQSKFSWFKYPNC 595

  Fly   382 ----------------GYRE-------GWWT---C--------TSFGVCTTF----KLFISQSGN 408
                            .|.|       .|:.   |        .:|.:..:|    ...:.|...
Mouse   596 SHYHHSQRCLCTQHLESYMELCLFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSE 660

  Fly   409 SKAYSLTVRVLLFACFLNDLIITSIYGGGLASILTIPSMDEAADTV------TRLRFHRLQ---- 463
            ....:|:.|::....:...|||.|.|...||:.||:..|:...|:.      |::.:..::
Mouse   661 LMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGAT 725

  Fly   464 ---------------WAANSEAWVSAIRASDEALVKDIL---YNFHIYSDD-ELLRLAQDQHMRI 509
                           ||..|....|.:..|:|..::.:|   |.|.:.|.. |.:........:|
Mouse   726 MTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQI 790

  Fly   510 GFTVERLPFGHFAIGNYLGPQAIDQLVIMKDDIYFQYTVAFVPRLWPLLDKLNTLIYSWHSSGFD 574
            |..::...:|   :|..:|....|::.|....:..:..:..:...|            |..:|..
Mouse   791 GGLIDSKGYG---VGTPMGSPYRDKITIAILQLQEEGKLHMMKEKW------------WRGNGCP 840

  Fly   575 KYWEYRVVADNLNLKIQQQVQETMTGTKDIGPVPLGMSNFAGFIIVWILGSAIA 628
                            :::.:|...         ||:.|..|..||...|..::
Mouse   841 ----------------EEESKEASA---------LGVQNIGGIFIVLAAGLVLS 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir41a	NP_995744.4	None
Grik2	XP_011241422.1	PBP1_iGluR_Kainate	37..414	CDD:380605
Grik2	XP_011241422.1	Periplasmic_Binding_Protein_Type_2	430..835	CDD:389745	82/433 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846626
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840