DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir41a and Grid1

DIOPT Version :9

Sequence 1:	NP_995744.4	Gene:	Ir41a / 2768714	FlyBaseID:	FBgn0040849	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_032192.2	Gene:	Grid1 / 14803	MGIID:	95812	Length:	1009	Species:	Mus musculus

Alignment Length:	704	Identity:	134/704 - (19%)
Similarity:	237/704 - (33%)	Gaps:	183/704 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 FWNDKFEFQLLHKSDYISFVGINIK-----------------------SFDDNGGHYIIDTGLKK 68
            |.|:..|..|..|..:..||...|.                       |..||           :
Mouse   239 FINEAVETNLASKDSHWVFVNEEISDPEILDLVHSALGRMTVVRQIFPSAKDN-----------Q 292

  Fly    69 KELQNKHLFLDELVIKIIISIEVTHCETFVVFDKDIDRFVNAFNK----------ASVYSI---- 119
            |.::|.|.....|.......:::.......::| .:....|||::          ||:..|
Mouse   293 KCMRNNHRISSLLCDPQEGYLQMLQISNLYLYD-SVLMLANAFHRKLEDRKWHSMASLNCIRKST 356

  Fly   120 --W---RSLHNKFVFAHIANESPESRNHFFED--QPNILFVVRDHSSASSFDIKTNKFVGRKAEN 177
              |   ||:.:.....||...:  ....|.||  .|.:.|.:...:.:.:|.....|.....:|.
Mouse   357 KPWNGGRSMLDTIKKGHITGLT--GVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEK 419

  Fly   178 PSQMILVDRYLASEQRFQFGKSLFADKLNNLQGREVIIAGFDYPPYTVIKHNMSTNAQDMGVSGE 242
            .....|.:|.:.|                .|||..:.:......|:.::..|:        :...
Mouse   420 GLNGSLQERPMGS----------------RLQGLTLKVVTVLEEPFVMVAENI--------LGQP 460

  Fly   243 SDFKNVYIDGTETRIVLN-FCEQFNCTIQIDSSAANDWGKVYPNMSGDGALGMLINRKADICIGA 306
            ..:|...||      ||: ..:......:|..:....:|....|.|.:|.:|.||:::||:.|.|
Mouse   461 KRYKGFSID------VLDALAKALGFKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISA 519

  Fly   307 MYSWYEDYTYLDLSMYLVRSGITCLVPAPLRLTSWYLPLEPFKETLWAAILLCLCAEATGLVL-- 369
            :....|..:.:|.|...:...:..|:..|....|.:....||...:||.|...:  ...|:::
Mouse   520 ITITPERESVVDFSKRYMDYSVGILIKKPEEKISIFSLFAPFDFAVWACIAAAI--PVVGVLIFV 582

  Fly   370 -----AYKSEQALYVLPGYREGWWTCTSFGVCTTFKLFISQSGNSKAYSLTVRVLLFACFLNDLI 429
                 |.:|:.|....|....   |..| .:...:..|:.|.|.|...|:.:|:::.:.:|..||
Mouse   583 LNRIQAVRSQSATQPRPSASA---TLHS-AIWIVYGAFVQQGGESSVNSVAMRIVMGSWWLFTLI 643

  Fly   430 ITSIYGGGLASILTIPSMDEAADTVTRL-----------------RFHRL-------QWAANSEA 470
            :.|.|...||:.||:..||....|...|                 .:.|.       |.:..:|.
Mouse   644 VCSSYTANLAAFLTVSRMDNPIRTFQDLSKQLEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAEL 708

  Fly   471 W--VSAIRASDEALVKDILYNFHIYSDDELLRLAQDQHMRIGFTVERLPFGHFAIGNYLGPQAID 533
            |  :|....:|..          :.:..|.:|.|:.              |::|   :|...|:.
Mouse   709 WRTISKNGGADNC----------VSNPSEGIRKAKK--------------GNYA---FLWDVAVV 746

  Fly   534 QLVIMKDDIYFQYTVAFVPRLWPLLDKLNTL------IYSWHSSGFDKYWEYRV--VADNLNLKI 590
            :...:.||   ..:|..:.         |::      |...|.|.:...:..|:  :.|..:|.:
Mouse   747 EYAALTDD---DCSVTVIG---------NSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDV 799

  Fly   591 QQQVQETMTGTKDIGP--------VPLGMSNFAGFIIVWILGSAIATLTFLLEL 636
            .:|.....||..|:..        ..|.:.:|||...:..:|..:|.|...|||
Mouse   800 LKQKWWPHTGRCDLTSHSSTQTEGKSLKLHSFAGVFCILAIGLLLACLVAALEL 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir41a	NP_995744.4	None
Grid1	NP_032192.2	Interaction with CBLN1. /evidence=ECO:0000269\|PubMed:27418511	21..436		39/226 (17%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	35/197 (18%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	81/428 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..960
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846303
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840