DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir41a and Gria4

DIOPT Version :9

Sequence 1:	NP_995744.4	Gene:	Ir41a / 2768714	FlyBaseID:	FBgn0040849	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	XP_006509904.1	Gene:	Gria4 / 14802	MGIID:	95811	Length:	912	Species:	Mus musculus

Alignment Length:	788	Identity:	151/788 - (19%)
Similarity:	250/788 - (31%)	Gaps:	280/788 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VLSAIVGKY----LNESTICI-FWNDKFEFQLLHKSD---------------------YISFVGI 48
            :|.||:.|.    .:.|.||: .:||....|||.:.|                     .|..||.
Mouse   166 ILQAIMEKAGQNGWHVSAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGK 230

  Fly    49 NIKSFDDNGGHYII-DTGLKKKELQNKHLFLDELVIKIIISIEVTHCETFVVFDKDIDRFVNA-- 110
            ::|     |.|||| :.|.|                                 |..::||::.
Mouse   231 HVK-----GYHYIIANLGFK---------------------------------DISLERFIHGGA 257

  Fly   111 ---------FNKASVYSI---WRSLHNKFVFAHIANESPESRNHFFEDQPNILFVVRDHSSASSF 163
                     ||...|..:   |:.|..:        |.|.|     |..|.       ::||.::
Mouse   258 NVTGFQLVDFNTPMVTKLMDRWKKLDQR--------EYPGS-----ETPPK-------YTSALTY 302

  Fly   164 D-----------IKTNKF-VGRKAE------NPS----QMILVDRYLAS---------------E 191
            |           ::..|. :.|:..      ||:    |.|.::|.|..               .
Mouse   303 DGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHYG 367

  Fly   192 QRFQFGKSLF------------------------ADKLNN----LQGREVIIAGFDYPPYTVIKH 228
            :|..:...:|                        |..|.|    ::.|.|::......||.:.|.
Mouse   368 RRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDAPTLGNDTAAIENRTVVVTTIMESPYVMYKK 432

  Fly   229 NMSTNAQDMGVSGESDFKNVYIDGTETRIVLNFCEQFNCTIQIDSS-AAND-----WGKVYPNMS 287
            |     .:| ..|...::...:| ..:.|..:...::...|..|.. .|.|     |
Mouse   433 N-----HEM-FEGNDKYEGYCVD-LASEIAKHIGIKYKIAIVPDGKYGARDADTKIW-------- 482

  Fly   288 GDGALGMLINRKADICIGAMYSWYEDYTYLDLSMYLVRSGITCLVPAPLRLTSWYLP-LEPFKET 351
             :|.:|.|:..||:|.|..:.........:|.|...:..||:.::..|.:....... |:|....
Mouse   483 -NGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYE 546

  Fly   352 LWAAILLCLCAEATGLVLAYKSEQALYVLPGYREGWWT--------------CTSFGVCTT--FK 400
            :|..|:....  ...:||...|..:.|       .|.|              ...||:..:  |.
Mouse   547 IWMCIVFAYI--GVSVVLFLVSRFSPY-------EWHTEEPEDGKEGPSDQPPNEFGIFNSLWFS 602

  Fly   401 L--FISQSGNSKAYSLTVRVLLFACFLNDLIITSIYGGGLASILTIPSM----DEAADTV----- 454
            |  |:.|..:....||:.|::....:...|||.|.|...||:.||:..|    :.|.|..
Mouse   603 LGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEI 667

  Fly   455 ---------TRLRFHRLQWAANSEAWVSAIRASDEALVKDILYNFHIYSDDELLRLAQDQHMRIG 510
                     |:..|.|.:.|...:.| :.:|:::.::       |...:.:.:.|:.:.:. :..
Mouse   668 AYGTLDSGSTKEFFRRSKIAVYEKMW-TYMRSAEPSV-------FTRTTAEGVARVRKSKG-KFA 723

  Fly   511 FTVE---------RLPFGHFAIGNYLGPQAIDQLVIMKDDIYFQYTVAFVPRLWPLLDKLNTLIY 566
            |.:|         |.|.....:|..|..:.              |.|| .|:...|...:|..:.
Mouse   724 FLLESTMNEYIEQRKPCDTMKVGGNLDSKG--------------YGVA-TPKGSSLRTPVNLAVL 773

  Fly   567 SWHSSGFDKYWEYRVVADNLNLKIQQQVQETMTGTKDIG----PVPLGMSNFAGFIIVWILGSAI 627
            ....:|         |.|.|..|......|  .|.||.|    ...|.:||.||...:.:.|..:
Mouse   774 KLSEAG---------VLDKLKNKWWYDKGE--CGPKDSGSKDKTSALSLSNVAGVFYILVGGLGL 827

  Fly   628 ATLTFLLE 635
            |.|..|:|
Mouse   828 AMLVALIE 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir41a	NP_995744.4	None
Gria4	XP_006509904.1	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	50/291 (17%)
Gria4	XP_006509904.1	PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	84/440 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846598
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840