DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir41a and Gria2

DIOPT Version :9

Sequence 1:	NP_995744.4	Gene:	Ir41a / 2768714	FlyBaseID:	FBgn0040849	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_001344853.2	Gene:	Gria2 / 14800	MGIID:	95809	Length:	901	Species:	Mus musculus

Alignment Length:	709	Identity:	141/709 - (19%)
Similarity:	236/709 - (33%)	Gaps:	209/709 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 DYISFVGINIKSFDDNGGHYII-DTGLKKKELQNKHLFLDELVIKIIISIEVTHCETFVVFDKDI 104
            |.:..:|.::|     |.|||| :.|           |.|..::|  |.....:...|.:.|.|
Mouse   221 DQVITIGKHVK-----GYHYIIANLG-----------FTDGDLLK--IQFGGANVSGFQIVDYD- 266

  Fly   105 DRFVNAFNKASVYSIWRSLHNK-FVFAHIANESPESRNHFFEDQPNILFVVRDHSSASSFD---I 165
            |..|:.|.:.     |.:|..| :..||.|...                    ::||.::|   :
Mouse   267 DSLVSKFIER-----WSTLEEKEYPGAHTATIK--------------------YTSALTYDAVQV 306

  Fly   166 KTNKF---------VGRKAE------NPS----QMILVDRYLASEQ--------RF-QFGKSL-- 200
            .|..|         :.|:..      ||:    |.:.::|.|...|        :| |.||.:
Mouse   307 MTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINY 371

  Fly   201 -------------------FADKL-------------NNLQGREVIIAGFDYPPYTVIKHNMSTN 233
                               ..||:             :.|:.:.|::......||.::|.|
Mouse   372 TINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKN---- 432

  Fly   234 AQDMGVSGESDFKNVYIDGTETRIVLNFCEQFNCTIQIDSS-AAND-----WGKVYPNMSGDGAL 292
             .:| :.|...::...:| ....|..:...::..||..|.. .|.|     |         :|.:
Mouse   433 -HEM-LEGNERYEGYCVD-LAAEIAKHCGFKYKLTIVGDGKYGARDADTKIW---------NGMV 485

  Fly   293 GMLINRKADICIGAMYSWYEDYTYLDLSMYLVRSGITCLVPAPLRLTSWYLP-LEPFKETLWAAI 356
            |.|:..||||.|..:.........:|.|...:..||:.::..|.:....... |:|....:|..|
Mouse   486 GELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCI 550

  Fly   357 LLCLCAEATGLVLAYKSEQALYVLPGYREGWWTCTS-----FGVCTT--FKL--FISQSGNSKAY 412
            :......:..|.|..:.....:....:.:|..|.:|     ||:..:  |.|  |:.|..:....
Mouse   551 VFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPR 615

  Fly   413 SLTVRVLLFACFLNDLIITSIYGGGLASILTIPSM---DEAADTV---------------TRLRF 459
            ||:.|::....:...|||.|.|...||:.||:..|   .|:|:.:               |:..|
Mouse   616 SLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFF 680

  Fly   460 HRLQWAANSEAWVSAIRASDEALVKDILYNF---------HIYSDDELLRLAQDQHMRIGFTVER 515
            .|.:.|...:.|.....|.....|:......         :.|    ||....::::.     :|
Mouse   681 RRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAY----LLESTMNEYIE-----QR 736

  Fly   516 LPFGHFAIGNYLGPQAIDQLVIMKDDIYFQYTVAFVPRLWPLLDKLNTLIYSWHSSGFDKYWEYR 580
            .|.....:|..|..:.              |.:| .|:...|...:|..:......|
Mouse   737 KPCDTMKVGGNLDSKG--------------YGIA-TPKGSSLRTPVNLAVLKLSEQG-------- 778

  Fly   581 VVADNLNLKIQQQVQETMTGTKDIG----PVPLGMSNFAGFIIVWILGSAIATLTFLLE 635
             |.|.|..|......|  .|.||.|    ...|.:||.||...:.:.|..:|.|..|:|
Mouse   779 -VLDKLKNKWWYDKGE--CGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIE 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir41a	NP_995744.4	None
Gria2	NP_001344853.2	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	43/220 (20%)
Gria2	NP_001344853.2	PBP2_iGluR_AMPA	413..794	CDD:270433	83/431 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846633
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840