DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCAP-R and Ptger4

DIOPT Version :9

Sequence 1:	NP_001368957.1	Gene:	CCAP-R / 2768688	FlyBaseID:	FBgn0039396	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_114465.3	Gene:	Ptger4 / 84023	RGDID:	628641	Length:	488	Species:	Rattus norvegicus

Alignment Length:	449	Identity:	98/449 - (21%)
Similarity:	167/449 - (37%)	Gaps:	111/449 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 STSSDPGEFDNLNSFYFYETEQFAVLWILFTVIVLGNSAVLFVMFINKNRKSRMNYFIKQLALAD 169
            |.||.|   :.|||       ...:..::|...|:||...:.|:.  |:||.:     |:.....
  Rat     9 SFSSTP---ERLNS-------PVTIPAVMFIFGVVGNLVAIVVLC--KSRKEQ-----KETTFYT 56

  Fly   170 LCVGLLNVLTDIIWRITIS-----------WRAGNLACKAIRFSQVCVTYSSTYVLVAMSIDRYD 223
            |..||  .:||::..:.:|           |......|....|..:....|...::.||||:||.
  Rat    57 LVCGL--AVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYL 119

  Fly   224 AITHPMNFSKSWKRARHLV----AGAWLI-----SALF-SLPILVLYEEKLIQGHPQCWIELGSP 278
            ||.|...:|       |.|    ||..|.     :.|| :||.:.|...:  :.:|..|..
  Rat   120 AINHAYFYS-------HYVDKRLAGLTLFAVYASNVLFCALPNMGLGRSE--RQYPGTWCF---- 171

  Fly   279 IAWQVYMSLVSA--------TLFAIPALI---ISACYAII--VKTIWAKGSIFVPTERAGFGAAP 330
            |.|...::..:|        :.|.|.|.:   :..|.|::  .:....:.|:......|...||.
  Rat   172 IDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAAAV 236

  Fly   331 A--------------------RRASSRGIIPRAKVKTVKMTLTIVFVFIICWSPYIIFDLLQVFG 375
            |                    ||..|...|..|:::.|.:.:....|.:||..|.::...:....
  Rat   237 ASVACRGHAAASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLY 301

  Fly   376 QIPHSQTNIAIATFIQS--LAPLNSAANPLIYCLFSSQVFRTLSRFPPFKWFTCC-CK---SYRN 434
            | |....:|:....:|:  :|.:|...:|.||.|....|   ||:  ..:...|. |:   |.|:
  Rat   302 Q-PSVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTV---LSK--AIEKIKCLFCRIGGSGRD 360

  Fly   435 NSQQNRCHTVGRRLHNSCDSMRTLTTSLTVSRRSTNKTNARVVICERPTKVVTVPAMSE 493
            .|.|:            |...|..:::::...||......|.:.....| ::.:|.::|
  Rat   361 GSAQH------------CSESRRTSSAMSGHSRSFLSRELREISSTSQT-LLYLPDLTE 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCAP-R	NP_001368957.1	7tmA_NPSR	124..416	CDD:320325	75/347 (22%)
		TM helix 1	126..150	CDD:320325	5/23 (22%)
		TM helix 2	159..182	CDD:320325	6/22 (27%)
		TM helix 3	197..219	CDD:320325	4/21 (19%)
		TM helix 4	240..256	CDD:320325	8/25 (32%)
		TM helix 5	282..305	CDD:320325	5/33 (15%)
		TM helix 6	348..370	CDD:320325	5/21 (24%)
		TM helix 7	384..409	CDD:320325	8/26 (31%)
Ptger4	NP_114465.3	7tmA_PGE2_EP4	18..344	CDD:320270	79/360 (22%)
		TM helix 1	20..44	CDD:320270	5/25 (20%)
		TM helix 2	55..77	CDD:320270	6/23 (26%)
		TM helix 3	93..115	CDD:320270	4/21 (19%)
		TM helix 4	138..154	CDD:320270	3/15 (20%)
		TM helix 5	181..204	CDD:320270	4/22 (18%)
		TM helix 6	274..296	CDD:320270	5/21 (24%)
		TM helix 7	311..336	CDD:320270	7/24 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	358..380		5/33 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000